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Parathyroidectomy for adults with primary hyperparathyroidism

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Appendices

Appendix 1. Search strategies

MEDLINE (Ovid SP)

1. Hyperparathyroidism, Primary/

2. (primary adj3 hyperparathyroid*).tw.

3. Parathyroid Neoplasms/

4. (parathyroid adj3 (adenoma? or hyperplasia? or neoplasm? or tumo?r?)).tw.

5. or/1‐4

6. Parathyroidectomy/

7. parathyroidectom*.tw.

8. (parathyroid* adj6 (surger* or surgic* or resection or excision or exploration)).tw.

9. ((endoscop* or video or camera or minimally invasive or small incision or open) adj6 (surger* or surgic* or resection or excision or exploration)).tw.

10. or/6‐9

11. 5 and 10

[Cochrane Handbook 2008 RCT filter ‐ sensitivity maximizing version]

12. randomized controlled trial.pt.

13. controlled clinical trial.pt.

14. randomi?ed.ab.

15. placebo.ab.

16. drug therapy.fs.

17. randomly.ab.

18. trial.ab.

19. groups.ab.

20. or/12‐19

21. exp animals/ not humans/

22. 20 not 21

23. 11 and 22

CENTRAL (Cochrane Library)

1. [mh "Hyperparathyroidism, Primary"]

2. (primary near/4 hyperparathyroid*):ti,ab,kw

3. [mh "Parathyroid Neoplasms"]

4. (parathyroid near/4 (adenoma* or hyperplasia* or neoplasm* or tumor* or tumour*)):ti,ab,kw

5. {or #1‐#4}

6. [mh "Parathyroidectomy"]

7. parathyroidectom*:ti,ab,kw

8. (parathyroid* near/7 (surgic* or resection or excision or exploration)):ti,ab,kw

9. ((endoscop* or video or camera or minimally invasive or small incision or open) near/7 (surgic* or resection or excision or exploration)):ti,ab,kw

10. surger*:ti,ab,kw

11. {or #6‐#10}

12. #5 and #11

LILACS (iAHx)

(MH:"Hyperparathyroidism, Primary" OR hyperparathyroid$ OR hiperparatireoid$ OR MH:"Parathyroid Neoplasms" OR (parathyroid AND (adenoma$ or hyperplasia$ or neoplasm$ or tumor$))) AND (MH:"Parathyroidectomy" OR parathyroidectom$ OR paratiroidectom$ OR cirur$ OR surger$ or surgic$ OR resection OR excision OR exploration) + Filter "Controlled Clinical Trial"

WHO ICTRP (Advanced search)

hyperparathyroid* AND parathyroidectom* OR

hyperparathyroid* AND surg* OR

parathyroid AND parathyroidectom* OR

parathyroid AND surg*

ClinicalTrials.gov (Advanced search)

Condition or disease: hyperparathyroidism OR parathyroid

Intervention/treatment: parathyroidectomy OR surgery OR surgical OR resection OR exploration

Appendix 2. 'Risk of bias' assessment

'Risk of bias' domains

Random sequence generation (selection bias due to inadequate generation of a randomised sequence)

For each included trial, we will describe the method used to generate the allocation sequence in sufficient detail to allow an assessment of whether it should produce comparable groups.

  • Low risk of bias: the trial authors achieved sequence generation using computer‐generated random numbers or a random numbers table. Drawing of lots, tossing a coin, shuffling cards or envelopes, and throwing dice are adequate if an independent person performed this who was not otherwise involved in the trial. We will consider the use of the minimisation technique as equivalent to being random.

  • Unclear risk of bias: insufficient information about the sequence generation process.

  • High risk of bias: the sequence generation method was non‐random or quasi‐random (e.g. sequence generated by odd or even date of birth; sequence generated by some rule based on date (or day) of admission; sequence generated by some rule based on hospital or clinic record number; allocation by judgment of the clinician; allocation by preference of the participant; allocation based on the results of a laboratory test or a series of tests; or allocation by availability of the intervention).

Allocation concealment (selection bias due to inadequate concealment of allocation prior to assignment)

We will describe for each included trial the method used to conceal allocation to interventions prior to assignment and we will assess whether intervention allocation could have been foreseen in advance of or during recruitment or changed after assignment.

  • Low risk of bias: central allocation (including telephone, interactive voice‐recorder, internet‐based and pharmacy‐controlled randomisation); sequentially numbered drug containers of identical appearance; sequentially numbered, opaque, sealed envelopes.

  • Unclear risk of bias: insufficient information about the allocation concealment.

  • High risk of bias: used an open random allocation schedule (e.g. a list of random numbers); assignment envelopes used without appropriate safeguards; alternation or rotation; date of birth; case record number; any other explicitly unconcealed procedure.

We will also evaluate trial baseline data to incorporate assessment of baseline imbalance into the 'Risk of bias' judgment for selection bias (Corbett 2014). Chance imbalances may also affect judgments on the risk of attrition bias. In the case of unadjusted analyses, we will distinguish between trials that we rate as being at low risk of bias on the basis of both randomisation methods and baseline similarity, and trials that we judge as being at low risk of bias on the basis of baseline similarity alone (Corbett 2014). We will reclassify judgements of unclear, low or high risk of selection bias as specified in Appendix 3.

Blinding of participants and study personnel (performance bias due to knowledge of the allocated interventions by participants and personnel during the trial)

We will evaluate the risk of detection bias separately for each outcome (Hróbjartsson 2013). We will note whether endpoints were self‐reported, investigator‐assessed or adjudicated outcome measures (see below).

  • Low risk of bias: blinding of participants and key study personnel was ensured, and it was unlikely that the blinding could have been broken; no blinding or incomplete blinding, but we judge that the outcome is unlikely to have been influenced by lack of blinding.

  • Unclear risk of bias: insufficient information about the blinding of participants and study personnel; the trial does not address this outcome.

  • High risk of bias: no blinding or incomplete blinding, and the outcome is likely to have been influenced by lack of blinding; blinding of trial participants and key personnel attempted, but likely that the blinding could have been broken, and the outcome is likely to be influenced by lack of blinding.

Blinding of outcome assessment (detection bias due to knowledge of the allocated interventions by outcome assessment

We will evaluate the risk of detection bias separately for each outcome (Hróbjartsson 2013). We will note whether endpoints were self‐reported, investigator‐assessed or adjudicated outcome measures (see below).

  • Low risk of bias: blinding of outcome assessment is ensured, and it is unlikely that the blinding could have been broken; no blinding of outcome assessment, but we judge that the outcome measurement is unlikely to have been influenced by lack of blinding.

  • Unclear risk of bias: insufficient information about the blinding of outcome assessors; the trial did not address this outcome.

  • High risk of bias: no blinding of outcome assessment, and the outcome measurement was likely to have been influenced by lack of blinding; blinding of outcome assessment, but likely that the blinding could have been broken, and the outcome measurement was likely to be influenced by lack of blinding.

Incomplete outcome data (attrition bias due to amount, nature or handling of incomplete outcome data)

For each included trial or each outcome, or both, we will describe the completeness of data, including attrition and exclusions from the analyses. We will state whether the trial reported attrition and exclusions, and report the number of participants included in the analysis at each stage (compared with the number of randomised participants per intervention/comparator groups). We will also note if the trial reported the reasons for attrition or exclusion and whether missing data were balanced across groups or were related to outcomes. We will consider the implications of missing outcome data per outcome such as high dropout rates (e.g. above 15%) or disparate attrition rates (e.g. difference of 10% or more between trial arms).

  • Low risk of bias: no missing outcome data; reasons for missing outcome data unlikely to be related to true outcome (for survival data, censoring unlikely to introduce bias); missing outcome data balanced in numbers across intervention groups, with similar reasons for missing data across groups; for dichotomous outcome data, the proportion of missing outcomes compared with observed event risk was not enough to have a clinically relevant impact on the intervention effect estimate; for continuous outcome data, plausible effect size (mean difference or standardised mean difference) among missing outcomes was not enough to have a clinically relevant impact on observed effect size; appropriate methods, such as multiple imputation, were used to handle missing data.

  • Unclear risk of bias: insufficient information to assess whether missing data in combination with the method used to handle missing data were likely to induce bias; the trial did not address this outcome.

  • High risk of bias: reason for missing outcome data was likely to be related to true outcome, with either imbalance in numbers or reasons for missing data across intervention groups; for dichotomous outcome data, the proportion of missing outcomes compared with observed event risk enough to induce clinically relevant bias in the intervention effect estimate; for continuous outcome data, plausible effect size (mean difference or standardised mean difference) among missing outcomes enough to induce clinically‐relevant bias in observed effect size; 'as‐treated' or similar analysis done with substantial departure of the intervention received from that assigned at randomisation; potentially inappropriate application of simple imputation.

Selective reporting (reporting bias due to selective outcome reporting)

We will assess outcome reporting bias by integrating the results of the appendix 'Matrix of trial endpoints (publications and trial documents)' (Boutron 2014; Jones 2015; Mathieu 2009), with those of the appendix 'High risk of outcome reporting bias according to the Outcome Reporting Bias In Trials (ORBIT) classification' (Kirkham 2010). This analysis will form the basis for the judgement of selective reporting.

  • Low risk of bias: the trial protocol was available and all the trial's prespecified (primary and secondary) outcomes that were of interest to this review were reported in the prespecified way; the study protocol was unavailable, but it was clear that the published reports included all expected outcomes (ORBIT classification).

  • Unclear risk of bias: insufficient information about selective reporting.

  • High risk of bias: not all the trial's prespecified primary outcomes were reported; one or more primary outcomes were reported using measurements, analysis methods or subsets of the data (e.g. subscales) that were not prespecified; one or more reported primary outcomes were not prespecified (unless clear justification for their reporting was provided, such as an unexpected adverse effect); one or more outcomes of interest in the Cochrane Review were reported incompletely so that we cannot enter them in a meta‐analysis; the trial report failed to include results for a key outcome that we would expect to have been reported for such a trial (ORBIT classification).

Other bias

  • Low risk of bias: the trial appears to be free from other sources of bias.

  • Unclear risk of bias: there was insufficient information to assess whether an important risk of bias existed; insufficient rationale or evidence that an identified problem introduced bias.

  • High risk of bias: the trial had a potential source of bias related to the specific trial design used; the trial was claimed to be fraudulent; or the trial had some other serious problem.

Appendix 3. Selection bias decisions

Selection bias decisions for trials that reported unadjusted analyses: comparison of results obtained using method details alone with results using method details and trial baseline informationa

Reported randomisation and allocation concealment methods

Risk of bias judgement using methods reporting

Information gained from study characteristics data

Risk of bias using baseline information and methods reporting

Unclear methods

Unclear risk

Baseline imbalances present for important prognostic variable(s)

High risk

Groups appear similar at baseline for all important prognostic variables

Low risk

Limited or no baseline details

Unclear risk

Would generate a truly random sample, with robust allocation concealment

Low risk

Baseline imbalances present for important prognostic variable(s)

Unclear riskb

Groups appear similar at baseline for all important prognostic variables

Low risk

Limited baseline details, showing balance in some important prognostic variablesc

Low risk

No baseline details

Unclear risk

Sequence is not truly randomised or allocation concealment is inadequate

High risk

Baseline imbalances present for important prognostic variable(s)

High risk

Groups appear similar at baseline for all important prognostic variables

Low risk

Limited baseline details, showing balance in some important prognostic variablesc

Unclear risk

No baseline details

High risk

aTaken from Corbett 2014; judgements highlighted in bold indicate situations in which the addition of baseline assessments would change the judgement about risk of selection bias, compared with using methods reporting alone.
bImbalance identified that appears likely to be due to chance.
cDetails for the remaining important prognostic variables are not reported.