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Chemo‐radiotherapy versus surgery‐based treatment for Stage IIIA non‐small cell lung cancer: a systematic review and network meta‐analysis

Appendices

Appendix 1. T,N,M descriptors for the eighth edition of TNM classification for lung cancer

T: Primary tumour

TX

Primary tumour cannot be assessed or tumor proven by presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy

T0

No evidence of primary tumour

Tis

Carcinoma in situ

T1

Tumour <=3cm in greatest dimension surrounded by lung or visceral pleura without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e. not in the main bronchus)

T1a(mi)

Minimally invasive adenocarcinoma

T1a

Tumour <= 1cm in greatest dimension

T1b

Tumour > 1cm but <= 2cm in greatest dimension

T1c

Tumour > 2cm but <= 3cm in greatest dimension

T2

Tumour > 3cm but <= 5cm or tumour with any of the following features:

‐involves main bronchus regardless of distance from the carina but without involvement of the carina

‐invades visceral pleura

‐associated with atelectasis or obstructive pneumonitis that extends to the hilar regionm involving part or all of the lung

T2a

Tumour < 3cm but <= 4cm in greatest dimension

T2b

Tumour > 4cm but <= 5cm in greatest dimension

T3

Tumour > 5cm but <= 7cm in greatest dimension or associated with separate tumour nodule(s) in the same lobe as the primary tunour or directly invades any of the following structures: chest wall (including parietal pleural and superior sulcus tumours), phrenic nerve, parietal pericardium

T4

Tumour > 7cm in greatest dimension or associated with separate tunour nodule(s) in a different ipsilateral lobe than that of the primary tumour or invades any of the following structures: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, and carina

N: Regional lymph node involvement

NX

Regional lymph nodes cannot be assessed

N0

No regional lymph node metastasis

N1`

Metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension

N2

Metastasis in ipsilateral mediastinal and/or subcarinal lymoh node(s)

N3

Metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)

M: Distant metastasis

M0

No distant metastasis

M1

Distant metastasis present

M1a

Separate tumour nodule(s) in a contralateral lobe; tumour with pleural or pericardial nodule(s) or malignant pleural or pericardial effusion

M1b

Single extrathoracic metastases

M1c

Multiple extrathoracic metastases in one or more organs

Stage groupings

Occult carcinoma

TXN0M0

Stage 0

TisN0M0

Stage IA1

T1a(mi)N0M0

T1aN0M0

Stage IA2

T1bN0M0

Stage IA3

T1cN0M0

Stage IB

T2aN0M0

Stage IIA

T2bN0M0

Stage IIB

T1a‐2bN1M0

T3N0M0

Stage IIIA

T1a‐2bN2M0

T3N1M0

T4N0‐1M0

Stage IIIB

T1a‐2bN3M0

T3‐4N2M0

Stage IIIC

T3‐4N3M0

Stage IVA

Any T, Any N, M1a‐b

Stage IVB

Any T, Any N, M1c

Appendix 2. CENTRAL search strategy

#1MeSH descriptor: [Carcinoma, Non‐Small‐Cell Lung] explode all trees
#2nsclc
#3lung cancer*
#4lung carcinom*
#5lung neoplasm*
#6lung tumor*
#7lung tumour*
#8non small cell*
#9nonsmall cell*
#10(#3 or #4 or #5 or #6 or #7) and (#8 or #9)
#11#1 or #2 or #10
#12MeSH descriptor: [Thoracic Surgical Procedures] explode all trees
#13surger*
#14surgic*
#15resect*
#16MeSH descriptor: [Pneumonectomy] explode all trees
#17pneumonectom*
#18MeSH descriptor: [Thoracotomy] explode all trees
#19thoracotom*
#20preoperat*
#21postoperat*
#22lobectom*
#23#12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22
#24MeSH descriptor: [Radiotherapy] explode all trees
#25MeSH descriptor: [Chemoradiotherapy] explode all trees
#26radiother*
#27chemorad*
#28chemo‐radiother*
#29chemother*
#30radiation therap*
#31MeSH descriptor: [Drug Therapy] explode all trees
#32antineoplas*
#33MeSH descriptor: [Antineoplastic Agents] explode all trees
#34#24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33
#35advanced
#36IIIa
#373a
#38#35 or #36 or #37
#39#23 and #34 and #38
#40#11 and #39

Appendix 3. MEDLINE search strategy

"#54,""Search #42 AND #53""
"#53,""Search #51 NOT #52""
"#52,""Search animals [MeSH Terms] NOT humans [MeSH Terms]""
"#51,""Search #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50""
"#50,""Search groups[Title/Abstract]""
"#49,""Search trial[Title/Abstract]""
"#48,""Search randomly""
"#47,""Search drug therapy[MeSH Subheading]""
"#46,""Search placebo[Title/Abstract]""
"#45,""Search randomized[Title/Abstract]"
"#44,""Search controlled clinical trial[Publication Type]""
"#43,""Search randomized controlled trial[Publication Type]""
"#42,""Search #11 AND #41""
"#41,""Search #23 AND #36 AND #40""
"#40,""Search #37 OR #38 OR #39""
"#39,""Search 3a""
"#38,""Search IIIa""
"#37,""Search advanced""
"#36,""Search #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35""
"#35,""Search antineoplastic agents[MeSH Terms]""
"#34,""Search antineoplas*""
"#33,""Search drug therapy[MeSH Terms]""
"#32,""Search radiation therap*""
"#31,""Search chemother*""
"#30,""Search chemo‐radiother*""
"#29,""Search chemorad*""
"#28,""Search radiother*""
"#27,""Search chemoradiotherapy[MeSH Terms]""
"#26,""Search Radiotherapy[MeSH Terms]""
"#23,""Search #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22""
"#22,""Search lobectom*""
"#21,""Search postoperat*""
"#20,""Search preoperat*""
"#19,""Search Thoracotom*""
"#18,""Search thoracotomy[MeSH Terms]""
"#17,""Search Pneumonectom*""
"#16,""Search pneumonectomy[MeSH Terms]""
"#15,""Search resect*""
"#14,""Search surgic*""
"#13,""Search surger*""
"#12,""Search thoracic surgical procedures[MeSH Terms]""
"#11,""Search #1 OR #2 OR #10""
"#10,""Search (#3 OR #4 OR #5 OR #6 OR #7) AND (#8 OR #9)""
"#9,""Search nonsmall cell*[Title/Abstract]""
"#8,""Search non small cell*[Title/Abstract]""
"#7,""Search lung tumour*[Title/Abstract]""
"#6,""Search lung tumor*[Title/Abstract]""
"#5,""Search lung neoplasm*[Title/Abstract]""
"#4,""Search lung carcinom*[Title/Abstract]""
"#3,""Search lung cancer*[Title/Abstract]""
"#2,""Search nsclc[Title/Abstract]""
"#1,""Search Carcinoma, Non‐Small‐Cell Lung[MeSH Terms]""

Appendix 4. Embase search strategy

#42 #11 AND #23 AND #36 AND #40 AND #41
#41 'crossover procedure'/exp OR 'double‐blind procedure'/exp OR 'randomized controlled trial'/exp OR 'single‐blind procedure'/exp OR random* OR factorial* OR crossover* OR cross NEXT/1 over* OR placebo* OR doubl* NEAR/1 blind* OR singl* NEAR/1 blind* OR assign* OR allocat* OR volunteer*
#40 #37 OR #38 OR #39
#39 3a:ti,ab
#38 iiia:ti,ab
#37 advanced:ti,ab
#36 #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35
#35 'molecularly targeted therapy'/exp
#34 'immunotherapy'/exp
#33 'antineoplastic agent'/exp
#32 antineoplas*:ti,ab
#31 'drug therapy'/exp
#30 'radiation therap*':ti,ab
#29 'chemother*':ti,ab
#28 'chemo rad*':ti,ab
#27 chemorad*:ti,ab
#26 radiother*:ti,ab
#25 'chemoradiotherapy'/exp
#24 'radiotherapy'/exp
#23 #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22
#22 lobectom*:ti,ab
#21 postoperat*:ti,ab
#20 preoperat*:ti,ab
#19 thoracotom*:ti,ab
#18 'thoracotomy'/exp
#17 pneumonectom*:ti,ab
#16 'lung resection'/exp
#15 resect*:ti,ab
#14 surgic*:ti,ab
#13 surger*:ti,ab
#12 'thorax surgery'/exp
#11 #1 OR #2 OR #10
#10 #3 OR #4 OR #5 OR #6 OR #7 AND (#8 OR #9)
#9 'nonsmall cell*':ti,ab
#8 'non small cell*':ti,ab
#7 'lung tumour*':ti,ab
#6 'lung tumor*':ti,ab
#5 'lung neoplasm*':ti,ab
#4 'lung carcinom*':ti,ab
#3 'lung cancer*':ti,ab
#2 'nsclc':ti,ab
#1 'non small cell lung cancer'/exp

Network geometry of all interventions
Figures and Tables -
Figure 1

Network geometry of all interventions