Database/ Resource

Strategy

MEDLINE OvidSP (1946 – present)

#1 Glycogen Storage Disease Type II/

#2 (glycogen storage disease adj2 (type 2 or type II)).tw.

#3 pompe disease.tw.

#4 1 or 2 or 3

#5 Enzyme Replacement Therapy/

#6 (enzyme* adj2 replac*).tw.

#7 (alglucosidase or myozyme or lumizyme or genzyme).tw.

#8 5 or 6 or 7

#9 4 and 8

#10 ((late or adult) adj3 onset).tw.

#11 9 and 10

#12 randomized controlled trial.pt.

#13 controlled clinical trial.pt.

#14 randomized.ab.

#15 placebo.ab.

#16 drug therapy.fs.

#17 randomly.ab.

#18 trial.ab.

#19 groups.ab.

#20 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19

#21 (animals not (humans and animals)).sh.

#22 20 not 21

#23 11 and 22

NOTE: Lines #12‐ #22 are the Cochrane Highly Sensitive Search Strategy for identifying randomized trials in MEDLINE: sensitivity‐maximizing version (2008 revision); Ovid format

Clinicaltrials.gov

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OTHER TERMS: alglucosidase OR myozyme OR lumizyme OR genzyme OR enzyme*

STUDY TYPE: Interventional Studies

CONDITION/ DISEASE: Pompe disease OR glycogen storage disease OR LOPD

WHO ICTRP

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CONDITION: Pompe disease OR glycogen storage disease OR LOPD

INTERVENTION: alglucosidase OR myozyme OR lumizyme OR genzyme OR enzyme*

RECRUITMENT STATUS: All