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Cochrane Database of Systematic Reviews

Rapid initiation of antiretroviral therapy for people living with HIV

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view the current version 17 June 2019

Information

DOI:
https://doi.org/10.1002/14651858.CD012962Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 19 February 2018see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:

  1. Cochrane Infectious Diseases Group

Copyright:
  1. Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Alberto Mateo‐Urdiales

    Correspondence to: Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK

    [email protected]

    [email protected]

  • Samuel Johnson

    Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK

  • Jean B Nachega

    Department of Epidemiology, Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, USA

    Department of Epidemiology and International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA

    Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa

  • Ingrid Eshun‐Wilson

    Centre for Evidence Based Health Care, Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Contributions of authors

AMU, IEW, and SJ contributed to the protocol design, writing, approved the final version, and responded to the referee comments.
JN helped design the protocol and the methods, approved the final version, and approved the response to the referee comments.

Sources of support

Internal sources

  • Liverpool School of Tropical Medicine, UK.

External sources

  • Department for International Development (DFID), UK.

    Grant: 5242

Declarations of interest

AMU has no known conflicts of interest.
SJ has no known conflicts of interest.
JBN has no known conflicts of interest.
IEW has no known conflicts of interest.

Acknowledgements

We thank Marcel Kitenge, Marty Richardson, and Paul Garner, who contributed to the planning of this protocol.

IEW, SJ, and the editorial base of the Cochrane Infectious Diseases Group are supported by the Effective Health Care Research Consortium. This Consortium is funded by UK aid from the UK Government for the benefit of developing countries (Grant: 5242). The views expressed in this publication do not necessarily reflect UK government policy.

Version history

Published

Title

Stage

Authors

Version

2019 Jun 17

Rapid initiation of antiretroviral therapy for people living with HIV

Review

Alberto Mateo‐Urdiales, Samuel Johnson, Rhodine Smith, Jean B Nachega, Ingrid Eshun‐Wilson

https://doi.org/10.1002/14651858.CD012962.pub2

2018 Feb 19

Rapid initiation of antiretroviral therapy for people living with HIV

Protocol

Alberto Mateo‐Urdiales, Samuel Johnson, Jean B Nachega, Ingrid Eshun‐Wilson

https://doi.org/10.1002/14651858.CD012962

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Adolescent; Adult; Child; Female; Humans; Male; Pregnancy;

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Conceptual model of factors influencing the HIV care continuum. Abbreviations: PLWH: people living with HIV, ART: antiretroviral therapy, IRIS: immune reconstitution inflammatory syndrome
Figures and Tables -
Figure 1

Conceptual model of factors influencing the HIV care continuum. Abbreviations: PLWH: people living with HIV, ART: antiretroviral therapy, IRIS: immune reconstitution inflammatory syndrome

Navigate to figure in ProtocolOpen in new tab
Table 1. Antiretroviral treatment and prophylaxis for pregnant women according to the WHO Prevention of mother‐to‐child transmission programmes

Options

Treatment for pregnant women with CD4 count < 350 cells/mm³

Prophylaxis for pregnant women with CD4 count > 350 cells/mm³

Option A

ART started as soon as HIV is diagnosed, continued for life

Antivirals started as soon as 14 weeks of gestation and continued until 7 days post‐partum

Option B

ART started as soon as HIV is diagnosed, continued for life

Antivirals started as soon as 14 weeks of gestation until childbirth if not breastfeeding or until one week after cessation of breastfeeding

Option B+

ART initiated as soon as HIV diagnosis and continued for life

Source: WHO 2012.

Figures and Tables -
Table 1. Antiretroviral treatment and prophylaxis for pregnant women according to the WHO Prevention of mother‐to‐child transmission programmes
Navigate to table in Protocol