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Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms

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References

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Table 1. What is the comparative effectiveness and safety of hybrid repair versus open surgical repair of thoracic aortic arch aneurysms?

Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms

Patient or population: patients with a diagnosis of thoracic aortic arch aneurysms

Settings: hospital, elective and emergency

Intervention: hybrid repair

Comparison: conventional open surgical repair

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Open surgical repair

Hybrid repair

Aneurysm related mortality

30 days

Follow up: median N

Study population

HR

N

(N to N)

N
(N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

Aneurysm related mortality

12 months

Follow up: median N

Study population

HR

N

(N to N)

N
(N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

Neurological deficit1

Follow up: median N

Study population

RR

N

(N to N)

N

(N to N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

N per 1000

(N to N)

Cardiovascular event2

Follow up: median N

Study population

RR

N

(N to N)

N

(N to N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

Respiratory compromise

Follow up: median N

Study population

RR

N

(N to N)

N

(N to N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

Graft patency

Follow up: median N

Study population

RR

N

(N to N)

N

(N to N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

Reintervention

Follow up: median N

Study population

RR

N

(N to N)

N

(N to N)

⊕⊝⊝⊝
very low

⊕⊕⊝⊝
low

⊕⊕⊕⊝
moderate

⊕⊕⊕⊕
high

N per 1000

(N to N)

N per 1000

(N to N)

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; HR: Hazard ratio; N: Number; RR: Risk ratio; OSR: open surgical repair

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 A neurological deficit event includes stroke or paraplegia
2 A cardiovascular event includes myocardial ischaemia or heart failure, or low cardiac output syndrome, or arrhythmia, or pericardial effusion

Figures and Tables -
Table 1. What is the comparative effectiveness and safety of hybrid repair versus open surgical repair of thoracic aortic arch aneurysms?
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