Database/ Resource

Strategy

CENTRAL (via the Cochrane Library)

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#1 MeSH descriptor: [Hyperlipoproteinemia Type II] this term only

#2 (familial or inherited) near/2 (hypercholesterol*mia*)

#3 (Hyperlipoprotein*mia*) near/2 (type II or type IIa or type IIb or type 2 or type 2a or type 2b)

#4 #1 or #2 or #3

#5 sequestrant*
#6 BAS
#7 (Colesevelam or Cholestagel or Welchol or Lodalis)
#8 MeSH descriptor: [Colesevelam Hydrochloride] this term only
#9 (Colestipol or Colestid or Cholestabyl)
#10 MeSH descriptor: [Colestipol] this term only
#11 (Cholestyramine or Colestyramine or Questran or Prevalite)
#12 MeSH descriptor: [Cholestyramine Resin] this term only
#13 #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12
#14 #4 and #13

Medline Ovid (1946 to present)

1. ((familial or inherited) adj2 hypercholesterol?emia$).tw.
2. Hyperlipoproteinemia Type II/

3. (Hyperlipoprotein?emia$ adj (type II or type IIa or type IIb or type 2 or type 2a or type 2b)).tw.

4. 1 or 2 or 3

5. sequestrant$.tw.

6. BAS.tw.

7. (Colesevelam or Cholestagel or Welchol or Lodalis).tw.
8. Colesevelam Hydrochloride/

9. (Colestipol or Colestid or Cholestabyl).tw.

10. Colestipol/

11. (Cholestyramine or Colestyramine or Questran or Prevalite).tw.

12. Cholestyramine Resin/

13. 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12

14. randomized controlled trial.pt.

15. controlled clinical trial.pt.

16. randomized.ab.

17. placebo.ab.

18. drug therapy.fs.

19. randomly.ab.

20. trial.ab.

21. groups.ab.

22. 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21

23. exp animals/ not humans.sh.

24. 22 not 23

25. 4 and 13 and 24

NOTE: Lines #16‐ #24 are the Cochrane Highly Sensitive Search Strategy for identifying randomized trials in MEDLINE: sensitivity‐maximizing version (2008 revision); Ovid format

Web of Science (1898 to present)

#1 TS=((familial or inherited) NEAR/2 hypercholesterol*emia*)
#2 TS=Hyperlipoprotein*emia*
#3 TS=(type II OR type IIa OR type IIb OR type 2 OR type 2a OR type 2b)
#4 #3 AND #2
#5 #4 OR #1
#6 TS=(sequestrant* OR BAS OR Colesevelam OR Cholestagel OR Welchol OR Lodalis OR Colestipol OR Colestid OR Cholestabyl OR Cholestyramine OR Colestyramine OR Questran OR Prevalite)
#7 #6 AND #5
#8 TS= clinical trial* OR TS=research design OR TS=comparative stud* OR TS=evaluation stud* OR TS=controlled trial* OR TS=follow‐up stud* OR TS=prospective stud* OR TS=random* OR TS=placebo* OR TS=(single blind*) OR TS=(double blind*) OR TS=(triple blind*) OR TS=(treble blind*) or TS=(singleblind*) OR TS=(doubleblind*) OR TS=(tripleblind*) OR TS=(trebleblind*) OR TS=blinded OR TS=cross* OR TS=RCT
#9 #8 AND #7

Note: Line #8 is based on a filter from University of Alberta Libraries http://guides.library.ualberta.ca/c.php?g=248586&p=1655962 (accessed 05 Oct 2017)

ClinicalTrials.gov

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OTHER TERMS: sequestrant OR sequestrants OR BAS OR Colesevelam OR Cholestagel OR Welchol OR Lodalis OR Colestipol OR Colestid OR Cholestabyl OR Cholestyramine OR Colestyramine OR Questran OR Prevalite

STUDY TYPE: Interventional Studies

CONDITION/ DISEASE: hypercholesterolemia OR hypercholesterolaemia OR Hyperlipoproteinemia OR Hyperlipoproteinaemia

WHO ICTRP

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CONDITION: hypercholesterolemia OR hypercholesterolaemia OR Hyperlipoproteinemia OR Hyperlipoproteinaemia

INTERVENTION: sequestrant OR sequestrants OR Colesevelam OR Cholestagel OR Welchol OR Lodalis OR Colestipol OR Colestid OR Cholestabyl OR Cholestyramine OR Colestyramine OR Questran OR Prevalite

RECRUITMENT STATUS: All