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Cochrane Database of Systematic Reviews

Non‐nutritive sweeteners for diabetes mellitus

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view the current version 25 May 2020

Information

DOI:
https://doi.org/10.1002/14651858.CD012885Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 27 November 2017see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:

  1. Cochrane Metabolic and Endocrine Disorders Group

Copyright:
  1. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Szimonetta Lohner

    Correspondence to: Cochrane Hungary, University of Pécs, Pécs, Hungary

    [email protected]

  • Ingrid Toews

    Cochrane Germany, Medical Center – Univ. of Freiburg, Faculty of Medicine, Univ. of Freiburg, Freiburg, Germany

  • Daniela Kuellenberg de Gaudry

    Cochrane Germany, Medical Center – Univ. of Freiburg, Faculty of Medicine, Univ. of Freiburg, Freiburg, Germany

  • Harriet Sommer

    Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center – University of Freiburg, Germany, Freiburg, Germany

  • Joerg J Meerpohl

    Cochrane Germany, Medical Center – Univ. of Freiburg, Faculty of Medicine, Univ. of Freiburg, Freiburg, Germany

Contributions of authors

The protocol drafting and search strategy development tasks correspond to the protocol version of this Cochrane Review; the other tasks correspond to planned activities for the review version.

All protocol authors read and approved the final protocol draft.

Szimonetta Lohner (SL): protocol drafting, search strategy development, acquisition of trial reports, trial selection, data extraction, data analysis, data interpretation, review drafting, and future review updates.

Ingrid Toews (IT): protocol drafting, acquisition of trial reports, trial selection, data extraction, data analysis, data interpretation, review drafting, and future review updates.

Daniela Kuellenberg de Gaudry (DK): protocol drafting, acquisition of trial reports, trial selection, data extraction, data analysis, data interpretation, review drafting, and future review updates.

Harriet Sommer (HS): protocol drafting, data extraction, data analysis, data interpretation, review drafting, and future review updates.

Joerg J Meerpohl (JM): protocol drafting, trial selection, data extraction, data analysis, data interpretation, review drafting, and future review updates.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • World Health Organization (WHO), Switzerland.

    Jorg Merpohl received financial support from the WHO to conduct a systematic review on health effects of non‐sugar sweeteners in healthy adults and children.

  • Alexander von Humboldt Foundation, Germany.

    Szimonetta Lohner was financially supported as a part of a Humbolt Research Fellowship.

Declarations of interest

SL: none known.

IT: none known.

DK: none known.

HS: none known.

JM: none known.

Acknowledgements

The CMED's Information Specialist (Maria‐Inti Metzendorf) reviewed the MEDLINE search strategy and adapted it to CENTRAL, ClinicalTrials.gov and WHO ICTRP Search Portal.

SL received research funding from the Alexander von Humboldt Foundation.

Version history

Published

Title

Stage

Authors

Version

2020 May 25

Non‐nutritive sweeteners for diabetes mellitus

Review

Szimonetta Lohner, Daniela Kuellenberg de Gaudry, Ingrid Toews, Tamas Ferenci, Joerg J Meerpohl

https://doi.org/10.1002/14651858.CD012885.pub2

2017 Nov 27

Non‐nutritive sweeteners for diabetes mellitus

Protocol

Szimonetta Lohner, Ingrid Toews, Daniela Kuellenberg de Gaudry, Harriet Sommer, Joerg J Meerpohl

https://doi.org/10.1002/14651858.CD012885

Notes

We have based parts of the Methods, as well as Appendix 1 and Appendix 2 of this Cochrane Protocol on a standard template established by the Cochrane Metabolic and Endocrine Disorders Group.

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Adult; Aged; Female; Humans; Male; Middle Aged;

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Table 1. Acceptable daily intake levels of non‐nutritive sweeteners as defined by regulatory bodies

Sweetener

FDA (mg/kg body weight) (FDA 2015a)

SCF/EFSA (mg/kg body weight) (Mortensen 2006)

JECFA (mg/kg body weight) (JECFA 2010)

ACE‐K

15

9

15

Advantame

32.8

5

5

Aspartame

50

40

40

Cyclamate

Not approved

7

11

Luo han guo fruit extracts

Not specified

Not specified

Not specified

Neohesperidine DC

Not approved

5

Not evaluated

Neotame

0.3

2

2

Saccharin

15

5

5

Sucralose

5

15

15

Steviol glycosides

4

4

4

Thaumatin

Not approved

Not specified

Not specified

Note: aspartame and acesulfame moieties in aspartame‐acesulfame salt are covered by acceptable daily intake values established for aspartame and acesulfame potassium

ACE‐K: acesulfame potassium; DC: dihydrochalcone; EFSA: European Food Safety Authority;FDA: Food and Drug Administration; JECFA: Joint FAO/WHO Expert Committee on Food Additives; SCF: Scientific Committee on Food (European Commission)

Figures and Tables -
Table 1. Acceptable daily intake levels of non‐nutritive sweeteners as defined by regulatory bodies
Navigate to table in Protocol