Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer
Appendices
Appendix 1. CENTRAL
#1 MeSH descriptor: [Breast Neoplasms] explode all trees
#2 (breast near cancer*):ti,ab,kw
#3 (breast near neoplasm*):ti,ab,kw
#4 (breast near carcinoma*):ti,ab,kw
#5 (breast near tumour*):ti,ab,kw
#6 (breast near tumor*):ti,ab,kw
#7 #1 or #2 or #3 or #4 or #5 or #6
#8 MeSH descriptor: [Anthracyclines] explode all trees
#9 (anthracycline* or doxorubicin or epirubicin or daunorubicin or idarubicin or valrubicin):ti,ab,kw
#10 #8 or #9
#11 MeSH descriptor: [Taxoids] explode all trees
#12 (taxane* or docetaxel or paclitaxel or nab‐paclitaxel or Cabazitaxel):ti,ab,kw
#13 #11 or #12
#14 #7 and #10 and #13
Appendix 2. MEDLINE
| 1 | exp Anthracyclines/ |
| 2 | anthracycline$.tw. |
| 3 | doxorubicin.tw. |
| 4 | epirubicin.tw. |
| 5 | daunorubicin.tw. |
| 6 | idarubicin.tw. |
| 7 | valrubicin.tw. |
| 8 | or/1‐7 |
| 9 | exp Taxoids/ |
| 10 | taxane$.tw. |
| 11 | docetaxel.tw. |
| 12 | paclitaxel.tw. |
| 13 | nab‐paclitaxel.tw. |
| 14 | Cabazitaxel.tw. |
| 15 | or/9‐14 |
| 16 | 8 and 15 |
| 17 | randomized controlled trial.pt. |
| 18 | controlled clinical trial.pt. |
| 19 | randomized.ab. |
| 20 | placebo.ab. |
| 21 | Clinical Trials as Topic/ |
| 22 | randomly.ab. |
| 23 | trial.ti. |
| 24 | (crossover or cross‐over).tw. |
| 25 | Pragmatic Clinical Trials as Topic/ |
| 26 | pragmatic clinical trial.pt. |
| 27 | or/17‐26 |
| 28 | exp Breast Neoplasms/ |
| 29 | (breast adj6 cancer$).tw. |
| 30 | (breast adj6 neoplasm$).tw. |
| 31 | (breast adj6 carcinoma$).tw. |
| 32 | (breast adj6 tumo?r$).tw. |
| 33 | or/28‐32 |
| 34 | 16 and 27 and 33 |
| 35 | remove duplicates from 34 |
| 36 | Animals/ not Humans/ |
| 37 | 35 not 36 |
Appendix 3. Embase
| 1 | Randomized controlled trial/ |
| 2 | Controlled clinical study/ |
| 3 | Random$.ti,ab. |
| 4 | randomization/ |
| 5 | intermethod comparison/ |
| 6 | placebo.ti,ab. |
| 7 | (compare or compared or comparison).ti. |
| 8 | (open adj label).ti,ab. |
| 9 | ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. |
| 10 | double blind procedure/ |
| 11 | parallel group$1.ti,ab. |
| 12 | (crossover or cross over).ti,ab. |
| 13 | ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. |
| 14 | (assigned or allocated).ti,ab. |
| 15 | (controlled adj7 (study or design or trial)).ti,ab. |
| 16 | (volunteer or volunteers).ti,ab. |
| 17 | trial.ti. |
| 18 | or/1‐17 |
| 19 | exp breast/ |
| 20 | exp breast disease/ |
| 21 | (19 or 20) and exp neoplasm/ |
| 22 | exp breast tumor/ |
| 23 | exp breast cancer/ |
| 24 | exp breast carcinoma/ |
| 25 | (breast$ adj5 (neoplas$ or cancer$ or carcin$ or tumo$ or metasta$ or malig$)).ti,ab. |
| 26 | or/21‐25 |
| 27 | exp anthracycline/ |
| 28 | anthracycline$.tw. |
| 29 | exp doxorubicin/ |
| 30 | doxorubicin.tw. |
| 31 | exp epirubicin/ |
| 32 | epirubicin.tw. |
| 33 | exp daunorubicin/ |
| 34 | daunorubicin.tw. |
| 35 | exp idarubicin/ |
| 36 | idarubicin.tw. |
| 37 | exp valrubicin/ |
| 38 | valrubicin.tw. |
| 39 | or/27‐38 |
| 40 | exp taxoid/ |
| 41 | taxane derivative/ |
| 42 | taxane$.tw. |
| 43 | exp docetaxel/ |
| 44 | docetaxel.tw. |
| 45 | exp paclitaxel/ |
| 46 | paclitaxel.tw. |
| 47 | nab‐paclitaxel.tw. |
| 48 | exp cabazitaxel/ |
| 49 | Cabazitaxel.tw. |
| 50 | or/40‐49 |
| 51 | 18 and 26 and 39 and 50 |
| 52 | limit 51 to (human and embase) |
Appendix 4. WHO ICTRP
Basic search:
Breast cancer AND Anthracycline AND Taxane
Advanced search:
Condition: Breast cancer
Intervention: (doxorubicin OR epirubicin OR daunorubicin OR idarubicin OR valrubicin) AND (docetaxel OR paclitaxel OR nab‐paclitaxel OR Cabazitaxel)
Recruitment status: ALL
Appendix 5. ClinicalTrials.gov
1. Condition/disease: Breast cancer
Intervention/treatment: Anthracyclines AND Taxanes
Filters: Interventional
2. Condition/disease: Breast cancer
Intervention/treatment: (doxorubicin OR epirubicin OR daunorubicin OR idarubicin OR valrubicin) AND (docetaxel OR paclitaxel OR nab‐paclitaxel OR Cabazitaxel)
Filters: Interventional
