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Aminoglycosides and metronidazole for people with cirrhosis and hepatic encephalopathy

Appendices

Appendix 1. Search strategies

Database

Time span

Search terms

The Cochrane Hepato‐Biliary Group Controlled Trials Register

Will be provided at review stage.

(aminoglycoside* or neomycin or neo‐fradin or neo‐tab or mycifradin or myciguent or paromomycin or humatin) AND (metronidazol* or elyzol or flagyl* or rozex or zidoval or metro* or protostat or noritate) AND (encephalopath* or fibro* or cirrho*)

Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library

Latest issue.

#1 MeSH descriptor: [Aminoglycosides] explode all trees

#2 (aminoglycoside* or neomycin or neo‐fradin or neo‐tab or mycifradin or myciguent or paromomycin or humatin)

#3 (#1 or #2)

#4 MeSH descriptor: [Metronidazole] explode all trees

#5 metronidazol* or elyzol or flagyl* or rozex or zidoval or metro* or protostat or noritate

#6 (#4 or #5)

#7 MeSH descriptor: [Hepatic Encephalopathy] explode all trees

#8 MeSH descriptor: [Fibrosis] explode all trees

#9 MeSH descriptor: [Liver Cirrhosis] explode all trees

#10 encephalopath* or fibro* or cirrho*

#11 (#7 or #8 or #9 or #10)

#12 (#3 and #6 and #11)

MEDLINE Ovid

From 1946 to date of search.

#1 exp Aminoglycosides/

#2 (aminoglycoside* or neomycin or neo‐fradin or neo‐tab or mycifradin or myciguent or paromomycin or humatin).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]

#3 (#1 or #2)

#4 exp Metronidazole/

#5 (metronidazol* or elyzol or flagyl* or rozex or zidoval or metro* or protostat or noritate).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]

#6 (#4 or #5)

#7 exp Hepatic Encephalopathy/

#8 exp Fibrosis/

#9 exp Liver Cirrhosis/

#10 (encephalopath* or fibro* or cirrho*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]

#11 (#7 or #8 or #9 or #10)

#12 (#3 and #6 and #11)

Embase Ovid

From 1974 to date of search.

#1 exp aminoglycoside/

#2 (aminoglycoside* or neomycin or neo‐fradin or neo‐tab or mycifradin or myciguent or paromomycin or humatin).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading]

#3 (#1 or #2)

#4 exp metronidazole/

#5 (metronidazol* or elyzol or flagyl* or rozex or zidoval or metro* or protostat or noritate).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading]

#6 (#4 or #5)

#7 exp hepatic encephalopathy/

#8 exp liver fibrosis/

#9 exp liver cirrhosis/

#10 (encephalopath* or fibro* or cirrho*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading]

#11 (#7 or #8 or #9 or #10)

#12 (#3 and #6 and #11)

Science Citation Index Expanded (Web of Science)

From 1900 to date of search.

#4 (#3 AND #2 AND #1)

#3 TS=(encephalopath* or fibro* or cirrho*)

#2 TS=(metronidazol* or elyzol or flagyl* or rozex or zidoval or metro* or protostat or noritate)

#1 TS=(aminoglycoside* or neomycin or neo‐fradin or neo‐tab or mycifradin or myciguent or paromomycin or humatin)