Wavefront excimer laser refractive surgery for adults with refractive errors
Appendices
Appendix 1. CENTRAL search strategy
#1 MeSH descriptor: [Corneal Surgery, Laser] explode all trees
#2 keratectom* or keratomileusis
#3 LASIK or Lasek or PRK
#4 laser* near/3 refractive near/3 surg$*
#5 laser* near/3 epithel* near/3 surg*
#6 MeSH descriptor: [Lasers, Excimer] this term only
#7 excimer near/3 laser*
#8 small incision lenticule extraction
#9 SMILE
#10 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9
#11 MeSH descriptor: [Corneal Wavefront Aberration] this term only
#12 wavefront*
#13 (high* or low*) near/3 aberration*
#14 HOA
#15 Customvue or Allegretto Wave
#16c custom or conventional
#17#11 or #12 or #13 or #15 or #16
#18#10 and #17
Appendix 2. MEDLINE Ovid search strategy
1. randomized controlled trial.pt.
2. (randomized or randomised).ab,ti.
3. placebo.ab,ti.
4. dt.fs.
5. randomly.ab,ti.
6. trial.ab,ti.
7. (group or groups).ab,ti.
8. or/1‐7
9. exp animals/
10. exp humans/
11. 9 not (9 and 10)
12. 8 not 11
13. exp corneal surgery, laser/
14. keratectom$.tw.
15. keratomileusis.tw.
16. LAS?K.tw.
17. PRK.tw.
18. (laser$ adj3 refractive adj3 surg$).tw.
19. (laser$ adj3 epithel$ adj3 surg$).tw.
20. Lasers, Excimer/
21. (excimer adj3 laser$).tw.
22. small incision lenticule extraction.tw.
23. SMILE.tw.
24. or/13‐23
25. Corneal Wavefront Aberration/
26. wavefront$.tw.
27. ((high$ or low$) adj3 aberration$).tw.
28. HOA.tw.
29. (Customvue or Allegretto Wave).tw.
30. (custom or conventional).tw.
31. or/25‐30
32. 24 and 31
33. 12 and 32
The search filter for trials at the beginning of the MEDLINE strategy is from the published paper by Glanville 2006.
Appendix 3. Embase Ovid search strategy
1. exp randomized controlled trial/
2. exp randomization/
3. exp double blind procedure/
4. exp single blind procedure/
5. random$.tw.
6. or/1‐5
7. (animal or animal experiment).sh.
8. human.sh.
9. 7 and 8
10. 7 not 9
11. 6 not 10
12. exp clinical trial/
13. (clin$ adj3 trial$).tw.
14. ((singl$ or doubl$ or trebl$ or tripl$) adj3 (blind$ or mask$)).tw.
15. exp placebo/
16. placebo$.tw.
17. random$.tw.
18. exp experimental design/
19. exp crossover procedure/
20. exp control group/
21. exp latin square design/
22. or/12‐21
23. 22 not 10
24. 23 not 11
25. exp comparative study/
26. exp evaluation/
27. exp prospective study/
28. (control$ or prospectiv$ or volunteer$).tw.
29. or/25‐28
30. 29 not 10
31. 30 not (11 or 23)
32. 11 or 24 or 31
33. keratectomy/
34. photorefractive keratectomy/
35. keratomileusis/
36. laser epithelial keratomileusis/
37. keratectom$.tw.
38. keratomileusis.tw.
39. LAS?K.tw.
40. PRK.tw.
41. (laser$ adj3 refractive adj3 surg$).tw.
42. (laser$ adj3 epithel$ adj3 surg$).tw.
43. excimer laser/
44. (excimer adj3 laser$).tw.
45. small incision lenticule extraction.tw.
46. SMILE.tw.
47. or/33‐46
48. corneal wavefront aberration/
49. wavefront$.tw.
50. ((high$ or low$) adj3 aberration$).tw.
51. HOA.tw.
52. (Customvue or Allegretto Wave).tw.
53. (custom or conventional).tw.
54. or/48‐52
55. 47 and 54
56. 32 and 55
Appendix 4. LILACS search strategy
keratectomy OR keratomileusis OR LASIK OR LASEK OR PRK OR excimer OR lenticule extraction OR SMILE and wavefront OR aberration OR custom OR conventional OR Customvue OR Allegretto Wave
Appendix 5. ISRCTN search strategy
(keratectomy OR keratomileusis OR LASIK OR LASEK OR PRK OR excimer OR "lenticule extraction" OR SMILE) AND (wavefront OR aberration OR custom OR conventional OR Customvue OR "Allegretto Wave")
Appendix 6. ClinicalTrials.gov search strategy
(keratectomy OR keratomileusis OR LASIK OR LASEK OR PRK OR excimer OR lenticule extraction OR SMILE) AND (wavefront OR aberration OR custom OR conventional OR Customvue OR Allegretto Wave)
Appendix 7. WHO ICTRP search strategy
wavefront OR aberration OR custom OR conventional OR Customvue OR Allegretto Wave = Title AND keratectomy OR keratomileusis OR LASIK OR LASEK OR PRK OR excimer OR lenticule extraction OR SMILE = Intervention
Appendix 8. Data on study characteristics
| Mandatory items | Optional items | |
| Methods | ||
| Study design | · Parallel group RCTi.e. people randomized to treatment · Within‐person RCTi.e. eyes randomized to treatment · Cluster RCTi.e. communities randomized to treatment · Cross‐over RCT · Other, specify | Exclusions after randomization Losses to follow up Number randomized/analyzed How were missing data handled? e.g.available case analysis, imputation methods Reported power calculation (Y/N), if yes, sample size and power Unusual study design/issues |
| Eyes or Unit of randomization/ unit of analysis | · One eye included in study, specify how eye selected · Two eyes included in study, both eyes received same treatment, briefly specify how analyzed(best/worst/average/both and adjusted for within person correlation/both and not adjusted for within person correlation) and specify if mixture one eye and two eye · Two eyes included in study, eyes received different treatments,specify if correct pair‐matched analysis done | |
| Participants | ||
| Country | Setting Ethnic group Equivalence of baseline characteristics (Y/N) | |
| Total number of participants | This information should be collected for total study population recruited into the study. If these data are only reported for the people who were followed up only, please indicate. | |
| Number (%) of men and women | ||
| Average age and age range | ||
| Inclusion criteria | ||
| Exclusion criteria | ||
| Interventions | ||
| Intervention (n= ) Comparator (n= ) See MECIR 65 and 70 | · Number of people randomized to this group · Drug (or intervention) name · Dose · Frequency · Route of administration | |
| Outcomes | ||
| Primary and secondary outcomes as defined in study reports See MECIR R70 | List outcomes Adverse events reported (Y/N) Length of follow up and intervals at which outcomes assessed | Planned/actual length of follow up |
| Trial information | Clinical trial registration number | |
