Appendix 1. MEDLINE Search strategy

1 anti‐sclerostin*.mp.

2 (sclerostin adj5 antibod*).mp.

3 (romosozumab* or "AMG 785" or AMG785 or "AMG‐785" or CDP7851 or "CDP 7851" or "CDP‐7851").mp.

4 (blosozumab* or LY2541546 or "LY 2541546" or "LY‐2541546").mp.

5 (BPS804 or "BPS 804" or "BPS‐804").mp.

6 or/1‐5

7 exp OSTEOPOROSIS/

8 OSTEOPOROTIC FRACTURES/

9 BONE DENSITY/

10 exp DENSITOMETRY/

11 osteoporo*.mp,kw,jw.

12 (bone* adj5 (lost or loss* or lose or losing or densit* or mass)).mp.

13 (bone* adj10 (postmenopaus* or post‐menopaus*)).mp.

14 (bone* adj5 (age* or aging)).mp.

15 (osteopeni* or osteopaeni* or (fractur* adj5 risk*)).mp.

16 (BMD or DEXA or DXA or FRAX).mp.

17 or/7‐16

18 6 and 17

19 (sclerostin adj10 antibod*).ti,ab. and osteoporo*.mp,kw,jw.

20 (NCT01575834 or NCT01631214 or NCT02791516 or NCT01575834 or NCT02186171 or NCT02016716 or NCT01796301 or NCT01992159 or NCT00896532 or NCT00907296 or NCT01081678).mp,sa. [romosozumab Phase II or III]

21 (NCT01144377 or NCT01406548 or NCT01406977or NCT01417091).mp,sa. [blosozumab or BPS804 Phase II or III]

22 or/18‐21

23 exp ANIMALS/ not HUMANS.sh.

24 22 not 23