Appendix 1. MEDLINE search strategy

1. exp osteoarthritis/

2. osteoarthr$.tw.

3. (degenerative adj2 arthritis).tw.

4. arthrosis.tw.

5. or/1‐4

6. Shoulder/

7. shoulder joint/

8. shoulder pain/

9. shoulder$.tw.

10. or/6‐9

11. hyaluronic.sh,tw,rn.

12. hyaluronan.tw.

13 sodium hyaluronate.tw.

14 (hylan or healonid).tw.

15 (hyalgan or hylectin or hyalflex).tw.

16 (hylartil or replasyn or suplasyn).tw.

17 (polyreumin or polireumin).tw.

18 nrd 101.tw

19 (artz or artzal).tw.

20 slm 10.tw.

21 (neovisc or orthovisc).tw.

22 adant.tw.

23 etapharm.tw.

24 or/11‐23

25. and/5,10,24

26. randomized controlled trial.pt.

27. controlled clinical trial.pt.

28. randomized.ab.

29. placebo.ab.

30. drug therapy.fs.

31. randomly.ab.

32. trial.ab.

33. groups.ab.

34. or/26‐33

35. (animals not (humans and animals)).sh.

36. 34 not 35

37. 21 and 36