Appendix 1. Search strategy

EMBASE (1946 ‐ present)

1. random$.tw.
2. factorial$.tw.
3. (crossover$ or cross over$ or cross‐over$).tw.
4. placebo$.tw.
5. single blind.mp.
6. double blind.mp.
7. triple blind.mp.
8. (singl$ adj blind$).tw.
9. (double$ adj blind$).tw.
10. (tripl$ adj blind$).tw.
11. assign$.tw.
12. allocat$.tw.
13. crossover procedure/
14. double blind procedure/
15. single blind procedure/
16. triple blind procedure/
17. randomized controlled trial/
18. or/1‐17
19. (exp animal/ or animal.hw. or nonhuman/) not (exp human/ or human cell/ or (human or humans).ti.)
20. 18 not 19
21. Exp Crohn disease/
22. Crohn*.mp.
23. inflammatory bowel disease*.mp.
24. IBD.mp.
25. 21 or 22 or 23 or 24
26. Infliximab.mp.
27. IFX.mp.
28. Remicade.mp.
29. 26 or 27 or 28
30. 20 and 25 and 29

MEDLINE (1946 ‐ present)

1. random$.tw.
2. factorial$.tw.
3. (crossover$ or cross over$ or cross‐over$).tw.
4. placebo$.tw.
5. single blind.mp.
6. double blind.mp.
7. triple blind.mp.
8. (singl$ adj blind$).tw.
9. (double$ adj blind$).tw.
10. (tripl$ adj blind$).tw.
11. assign$.tw.
12. allocat$.tw.
13. crossover procedure/
14. double blind procedure/
15. single blind procedure/
16. triple blind procedure/
17. randomized controlled trial/
18. or/1‐17
19. (exp animal/ or animal.hw. or nonhuman/) not (exp human/ or human cell/ or (human or humans).ti.)
20. 18 not 19
21. Exp Crohn disease/
22. Crohn*.mp.
23. inflammatory bowel disease*.mp.
24. IBD.mp.
25. 21 or 22 or 23 or 24
26. Infliximab.mp.
27. IFX.mp.
28. Remicade.mp.
29. 26 or 27 or 28
30. 20 and 25 and 29

Conchrane CENTRAL

#1 MeSH descriptor: [Crohn Disease] explode all trees
#2 Crohn
#3 Inflammatory Bowel Disease
#4 IBD
#5 #1 or #2 or #3 or #4
#6 Infliximab
#7 IFX
#8 Remicade
#9 #6 or #7 or #8
#10 #5 and #9