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Interventions to help support caregivers of people with a brain or spinal cord tumour

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view the current version 02 July 2019

Appendices

Appendix 1. MEDLINE search strategy

1. exp Central Nervous System Neoplasms/
2. ((brain or cereb* or spinal cord or CNS or central nervous system) adj5 (cancer* or carcinoma* or tumor* or tumour* or malignan* or neoplas* or lymphoma* or hemangioma*)).mp.
3. exp Glioma/
4. (glioma* or astrocytoma* or meningioma* or oligodendroglioma* or glioblastoma* or ependymoma* or medulloblastoma* or craniopharyngioma* or pineal or pituitary or PNET* or DNET* or schwannoma*).mp.
5. 1 or 2 or 3 or 4
6. Caregivers/
7. exp Family/
8. (caregiver* or care giver* or carer*).mp.
9. ((family or families or spouse* or partner* or parent* or grandparent* or sibling* or relative* or friend* or husband* or wife or wives or close person* or significant other* or child or children) and (care or caring)).mp.
10. 6 or 7 or 8 or 9
11. 5 and 10
12. randomized controlled trial.pt.
13. controlled clinical trial.pt.
14. randomized.ab.
15. placebo.ab.
16. clinical trials as topic.sh.
17. randomly.ab.
18. trial.ti.
19. 12 or 13 or 14 or 15 or 16 or 17 or 18
20. 11 and 19

Key:

mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, pt=publication type,ab=abstract, ti=title, sh=subject heading

Appendix 2. Example 'Summary of Findings' table

Title: Interventions to help support caregivers of people with a brain or spinal cord tumour

Patient or population: Adult caregivers of patients with a brain or spinal cord tumour

Settings: Any

Intervention: Any intervention aimed at improving caregiver well‐being

Comparison: Any control condition (e.g. waiting list control groups; attention only control groups; information only control groups)

Outcomes

Illustrative comparative risks*

Relative effect (95% CI)

No of participants

(studies)

Quality of evidence

(GRADE)

Comment

Assumed risk

Corresponding risk

1. Caregiver psychological distress

2. Caregiver burden

3. Caregiver mastery

4. Quality of patient‐caregiver relationship

5. Caregiver quality of life

6. Caregiver physical functioning

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the
assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; HR: hazard ratio; MD: mean difference; RR: risk ratio; OR: odds ratio

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.