Medical interventions for treating primary angle‐closure glaucoma
Appendices
Appendix 1. CENTRAL search strategy
#1 MeSH descriptor: [Glaucoma, Angle‐Closure] explode all trees
#2 (angle* near/3 closure*)
#3 (angle* near/3 close*)
#4 (Uncompensat* near/2 glaucoma*)
#5 (Narrow* near/2 angle*)
#6 (occlude* near/3 angle*)
#7 Acute glaucoma*
#8 (APAC or AACG or PACG or PACS)
#9 pupillary block glaucoma*
#10 {or #1‐#9}
#11 MeSH descriptor: [Adrenergic beta‐Antagonists] explode all trees
#12 ((Adrenergic near/1 beta* near/3 Blocker*) or (Adrenergic near/1 beta* near/3 Blockader*) or (beta* near/1 Adrenergic near/3 Blocking near/3 Agent*) or (Adrenergic near/1 beta* near/3 Antagonist*) or (beta* near/1 Adrenergic near/3 Blocking near/3 drug*) or (beta* near/2 antagonist*) or (beta* near/2 blocker*) or (beta* near/3 blocking near/2 agent*) or (beta near/3 blocking near/2 drug*) or (Beta* antiadrenergic agent*) or (beta* sympathicolytic*) or (beta* sympatholytic*))
#13 MeSH descriptor: [Timolol] explode all trees
#14 (Timolol* or Timoptic or Timoptol or Timacar or "L‐714,465" or L714465 or "MK‐950" or MK950 or Optimol or Blocadren or "26839‐75‐8")
#15 MeSH descriptor: [Metipranolol] explode all trees
#16 (Metipranolol* or Methypranol or Trimepranol or Disorat or "22664‐55‐7")
#17 MeSH descriptor: [Carteolol] explode all trees
#18 (Carteolol* or "OPC‐1085" or OPC1085 or "51781‐06‐7")
#19 MeSH descriptor: [Levobunolol] explode all trees
#20 (Levobunolol* or PMSLevobunolol or Ultracortenol or Vistagan or "W‐6412A" or W6412A or AKBeta or ApoLevobunolol or Betagan or Bunolol or NovoLevobunolol or "W‐7000A" or W7000A or "47141‐42‐4")
#21 MeSH descriptor: [Betaxolol] explode all trees
#22 (Betaxolol* or Kerlone or Kerlon or Oxodal or "SL‐75212" or SL75212 or "ALO‐1401‐02" or ALO140102 or Betoptic or Betoptima or "63659‐18‐7")
#23 MeSH descriptor: [Prostaglandins] explode all trees
#24 (Prostaglandin* or Prostanoid* or "PG Analogs" or dimethylprostaglandin or methylprostaglandin)
#25 (latanoprost* or PHXA41 or Xalatan or PhXA34 or "130209‐82‐4")
#26 (travoprost* or Travatan or "AL‐6221" or AL6221 or "157283‐68‐6")
#27 (bimatoprost* or latisse or Lumigan or AGN192024)
#28 (unoprostone* or "UF‐021" or Rescula or Eescula or "69553‐75‐9")
#29 (tafluprost* or "AFP 168" or AFP168 or "de 085" or de085 or taflotan or tapros or zioptan or "209860‐87‐7")
#30 MeSH descriptor: [Antihypertensive Agents] explode all trees
#31 antihypertensive* or "Anti Hypertensives" or "Anti Hypertensive"
#32 MeSH descriptor: [Miotics] explode all trees
#33 MeSH descriptor: [Pilocarpine] explode all trees
#34 (Pilocarpin* or Isoptocarpine or Salagen or Isopilocarpine or Ocusert or adsorbocarpine or akarpine or almocarpine or asthenopin or glaucocarpine or "isopto carpine" or isoptopilocarpine or liocarpina or miocarpine or "ocu‐carpine" or ocucarpine or pilagan or pilasite or pilocar or pilocarpin or pilocarpol or pilofrin or pilogel or piloheptine or pilomann or pilomin or pilomiotin or pilopine or pilostat or pilosyst or pilotonina or sanpilo or "sno pilo" or spersacarpine or vistacarpin or vitacarpine or zhenrui or "148‐72‐1" or "54‐71‐7" or "92‐13‐7")
#35 (drug* or medic* or pharmacologic*) near/3 (treat* or therap* or intervent*)
#36 {or #11‐#35}
#37 #10 and #36
Appendix 2. MEDLINE (Ovid) search strategy
1. Randomized Controlled Trial.pt.
2. Controlled Clinical Trial.pt.
3. (randomized or randomised).ab,ti.
4. placebo.ab,ti.
5. drug therapy.fs.
6. randomly.ab,ti.
7. trial.ab,ti.
8. groups.ab,ti.
9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
10. exp animals/ not humans.sh.
11. 9 not 10
12. exp Glaucoma, Angle‐Closure/
13. (angle* adj3 closure*).tw.
14. (angle* adj3 close*).tw.
15. (Uncompensat* adj2 glaucoma*).tw.
16. (Narrow* adj2 angle*).tw.
17. (occlude* adj3 angle*).tw.
18. Acute glaucoma*.tw.
19. (APAC or AACG or PACG or PACS).tw.
20. pupillary block glaucoma.tw.
21. or/12‐20
22. exp adrenergic beta antagonists/
23. ((Adrenergic adj1 beta* adj3 Blocker*) or (Adrenergic adj1 beta* adj3 Blockader*) or (beta* adj1 Adrenergic adj3 Blocking adj3 Agent*) or (Adrenergic adj1 beta* adj3 Antagonist*) or (beta* adj1 Adrenergic adj3 Blocking adj3 drug*) or (beta* adj2 antagonist*) or (beta* adj2 blocker*) or (beta* adj3 blocking adj2 agent*) or (beta adj3 blocking adj2 drug*) or Beta* antiadrenergic agent* or beta* sympathicolytic* or beta* sympatholytic*).tw.
24. exp timolol/
25. (Timolol* or Timoptic or Timoptol or Timacar or timogel or timod or timolabak or droptimol or "L‐714,465" or L714465 or "MK‐950" or MK950 or Optimol or Blocadren or "26839‐75‐8").tw.
26. exp metipranolol/
27. (Metipranolol* or Methypranol or Trimepranol or Disorat or "22664‐55‐7").tw.
28. exp carteolol/
29. (Carteolol* or carteabak or fortinol or "OPC‐1085" or OPC1085 or "51781‐06‐7").tw.
30. exp levobunolol/
31. (Levobunolol* or PMSLevobunolol or Ultracortenol or Vistagan or "W‐6412A" or W6412A or AKBeta or ApoLevobunolol or Betagan or Bunolol or NovoLevobunolol or "W‐7000A" or W7000A or "47141‐42‐4").tw.
32. exp betaxolol/
33. (Betaxolol* or Kerlone or Kerlon or Oxodal or "SL‐75212" or SL75212 or "ALO‐1401‐02" or ALO140102 or Betoptic or Betoptima or "63659‐18‐7").tw.
34. exp Prostaglandins/
35. (Prostaglandin* or Prostanoid* or "PG Analogs" or dimethylprostaglandin or methylprostaglandin).tw.
36. latanoprost.rn.
37. (latanoprost* or PHXA41 or Xalatan or PhXA34 or "130209‐82‐4").tw.
38. travoprost.rn.
39. (travoprost* or Travatan or "AL‐6221" or AL6221 or "157283‐68‐6").tw.
40. bimatoprost.rn.
41. (bimatoprost* or latisse or Lumigan or AGN192024).tw.
42. isopropyl unoprostone.rn.
43. (unoprostone* or "UF‐021" or Rescula or Eescula or "69553‐75‐9").tw.
44. tafluprost.rn.
45. (tafluprost* or "AFP 168" or AFP168 or "de 085" or de085 or taflotan or tapros or zioptan or saflutan or "209860‐87‐7").tw.
46. exp antihypertensive agents/
47. (antihypertensive* or "Anti Hypertensives" or "Anti Hypertensive").tw.
48. exp Miotics/
49. exp pilocarpine/
50. (Pilocarpin* or Isoptocarpine or Salagen or Isopilocarpine or Ocusert or adsorbocarpine or akarpine or almocarpine or asthenopin or glaucocarpine or "isopto carpine" or isoptopilocarpine or liocarpina or miocarpine or "ocu‐carpine" or ocucarpine or pilagan or pilasite or pilocar or pilocarpin or pilocarpol or pilofrin or pilogel or piloheptine or pilomann or pilomin or pilomiotin or pilopine or pilostat or pilosyst or pilotonina or sanpilo or "sno pilo" or spersacarpine or vistacarpin or vitacarpine or zhenrui or "148‐72‐1" or "54‐71‐7" or "92‐13‐7").tw.
51. ((drug* or medic* or pharmacologic*) adj3 (treat* or therap* or intervent*)).tw.
52. or/22‐51
53. 21 and 52
54. 11 and 53
The search filter for trials at the beginning of the MEDLINE strategy is from the published paper by Glanville (Glanville 2006).
Appendix 3. EMBASE.com search strategy
#1 'randomized controlled trial'/exp
#2 'randomization'/exp
#3 'double blind procedure'/exp
#4 'single blind procedure'/exp
#5 random*:ab,ti
#6 #1 OR #2 OR #3 OR #4 OR #5
#7 'animal'/exp OR 'animal experiment'/exp
#8 'human'/exp
#9 #7 AND #8
#10 #7 NOT #9
#11 #6 NOT #10
#12 'clinical trial'/exp
#13 (clin* NEAR/3 trial*):ab,ti
#14 ((singl* OR doubl* OR trebl* OR tripl*) NEAR/3 (blind* OR mask*)):ab,ti
#15 'placebo'/exp
#16 placebo*:ab,ti
#17 random*:ab,ti
#18 'experimental design'/exp
#19 'crossover procedure'/exp
#20 'control group'/exp
#21 'latin square design'/exp
#22 #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21
#23 #22 NOT #10
#24 #23 NOT #11
#25 'comparative study'/exp
#26 'evaluation'/exp
#27 'prospective study'/exp
#28 control*:ab,ti OR prospectiv*:ab,ti OR volunteer*:ab,ti
#29 #25 OR #26 OR #27 OR #28
#30 #29 NOT #10
#31 #30 NOT (#11 OR #23)
#32 #11 OR #24 OR #31
#33 'closed angle glaucoma'/exp
#34 (angle* NEAR/3 closure*):ab,ti
#35 (angle* NEAR/3 close*):ab,ti
#36 (uncompensat* NEAR/2 glaucoma*):ab,ti
#37 (narrow* NEAR/2 angle*):ab,ti
#38 (occlude* NEAR/3 angle*):ab,ti
#39 (acute NEAR/1 glaucoma*):ab,ti
#40 apac:ab,ti OR aacg:ab,ti OR pacg:ab,ti OR pacs:ab,ti
#41 ('pupillary block' NEAR/2 glaucoma):ab,ti
#42 #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41
#43 'beta adrenergic receptor blocking agent'/exp
#44 (adrenergic NEAR/1 beta* NEAR/3 blocker*):ab,ti OR (adrenergic NEAR/1 beta* NEAR/3 blockader*):ab,ti OR (beta* NEAR/1 adrenergic NEAR/3 blocking NEAR/3 agent*):ab,ti OR (adrenergic NEAR/1 beta* NEAR/3 antagonist*):ab,ti OR (beta* NEAR/1 adrenergic NEAR/3 blocking NEAR/3 drug*):ab,ti OR (beta* NEAR/2 antagonist*):ab,ti OR (beta* NEAR/2 blocker*):ab,ti OR (beta* NEAR/3 blocking NEAR/2 agent*):ab,ti OR (beta NEAR/3 blocking NEAR/2 drug*):ab,ti OR (beta* NEAR/1 antiadrenergic NEAR/1 agent*):ab,ti OR (beta* NEAR/1 sympathicolytic*):ab,ti OR (beta* NEAR/1 sympatholytic*):ab,ti
#45 'timolol'/exp
#46 timolol*:ab,ti OR timoptic:ab,ti OR timoptol:ab,ti OR timacar:ab,ti OR timogel:ab,ti OR timod:ab,ti OR timolabak:ab,ti OR droptimol:ab,ti OR 'l 714465':ab,ti OR l714465:ab,ti OR 'mk 950':ab,ti OR mk950:ab,ti OR blocadren:ab,ti OR '26839 75 8':ab,ti OR 'apo timolol':ab,ti OR 'apo timol':ab,ti OR 'apo timop':ab,ti OR 'apotimol':ab,ti OR apotimolol:ab,ti OR apotimop:ab,ti OR betimol:ab,ti OR istalol:ab,ti OR moducren:ab,ti OR nyolol:ab,ti OR ofal:ab,ti OR ofan:ab,ti OR optimol:ab,ti OR timolo:ab,ti OR titol:ab,ti
#47 'metipranolol'/exp
#48 metipranolol*:ab,ti OR methypranol:ab,ti OR trimepranol:ab,ti OR disorat:ab,ti OR '22664 55 7':ab,ti OR 'beta ophtiole':ab,ti OR betalol:ab,ti OR betamann:ab,ti OR betamet:ab,ti OR betanol:ab,ti OR betanolol:ab,ti OR glauline:ab,ti OR 'normoglaucon mite':ab,ti OR ophtiole:ab,ti OR optipranolol:ab,ti
#49 'carteolol'/exp
#50 carteolol*:ab,ti OR carteabak:ab,ti OR fortinol:ab,ti OR opc1085:ab,ti OR '51781 06 7':ab,ti OR '51781 21 6':ab,ti OR arteolol:ab,ti OR arteoptic:ab,ti OR arteoptik:ab,ti OR caltamol:ab,ti OR calte:ab,ti OR carbonolol:ab,ti OR carteabak:ab,ti OR carteol:ab,ti OR cartrol:ab,ti OR 'catelon eye drop':ab,ti OR elebloc:ab,ti OR endak:ab,ti OR glauteolol:ab,ti OR karol:ab,ti OR karteol:ab,ti OR mikelan:ab,ti OR ocupress:ab,ti OR 'opc 1085':ab,ti OR stobol:ab,ti OR teoptic:ab,ti
#51 'levobunolol'/exp
#52 levobunolol*:ab,ti OR pmslevobunolol:ab,ti OR ultracortenol:ab,ti OR vistagan:ab,ti OR 'w 6412a':ab,ti OR w6412a:ab,ti OR akbeta:ab,ti OR apolevobunolol:ab,ti OR betagan:ab,ti OR bunolol:ab,ti OR novolevobunolol:ab,ti OR w7000a:ab,ti OR '47141 42 4':ab,ti OR 'ak‐beta':ab,ti OR 'ak beta':ab,ti OR betasite:ab,ti OR bunolgan:ab,ti OR gotensin:ab,ti OR 'w 7000a':ab,ti
#53 'betaxolol'/exp
#54 betaxolol*:ab,ti OR kerlone:ab,ti OR kerlon:ab,ti OR oxodal:ab,ti OR sl75212:ab,ti OR alo140102:ab,ti OR betoptic:ab,ti OR betoptima:ab,ti OR '63659 18 7':ab,ti OR 'alo 1401 02':ab,ti OR betac:ab,ti OR betarun:ab,ti OR betasel:ab,ti OR betaxon:ab,ti OR betoquin:ab,ti OR kerlong:ab,ti OR levobetaxolol:ab,ti OR lokren:ab,ti OR optibet:ab,ti OR optipress:ab,ti OR 'sl 75212':ab,ti OR tonobexol:ab,ti OR '72424 72 7':ab,ti OR '93221 48 8':ab,ti
#55 'prostaglandin'/exp
#56 prostaglandin*:ab,ti OR prostanoid*:ab,ti OR 'pg analogs':ab,ti OR dimethylprostaglandin:ab,ti OR methylprostaglandin:ab,ti
#57 'latanoprost'/exp
#58 latanoprost*:ab,ti OR phxa41:ab,ti OR xalatan:ab,ti OR phxa34:ab,ti OR '130209 82 4':ab,ti OR loutenor:ab,ti
#59 'travoprost'/exp
#60 travoprost*:ab,ti OR travatan:ab,ti OR 'al 6221':ab,ti OR al6221:ab,ti OR '157283 68 6':ab,ti OR 'fluprostenol isopropyl ester':ab,ti OR 'travatan z':ab,ti
#61 'bimatoprost'/exp
#62 bimatoprost*:ab,ti OR latisse:ab,ti OR lumigan:ab,ti OR agn192024:ab,ti OR 'agn 192024':ab,ti OR '155206 00 1':ab,ti
#63 'unoprostone isopropyl ester'/exp
#64 unoprostone*:ab,ti OR rescula:ab,ti OR eescula:ab,ti OR '69553 75 9':ab,ti OR '120373 24 2':ab,ti OR 'uf 021':ab,ti OR uf021:ab,ti
#65 'tafluprost'/exp
#66 tafluprost*:ab,ti OR 'afp 168':ab,ti OR afp168:ab,ti OR 'de 085':ab,ti OR de085:ab,ti OR taflotan:ab,ti OR tapros:ab,ti OR zioptan:ab,ti OR saflutan:ab,ti OR '209860 87 7':ab,ti
#67 'antihypertensive agent'/exp
#68 antihypertensive*:ab,ti OR 'anti hypertensives':ab,ti OR 'anti hypertensive':ab,ti
#69 'miotic agent'/de
#70 'pilocarpine'/exp
#71 pilocarpin*:ab,ti OR isoptocarpine:ab,ti OR salagen:ab,ti OR isopilocarpine:ab,ti OR ocusert:ab,ti OR adsorbocarpine:ab,ti OR akarpine:ab,ti OR almocarpine:ab,ti OR asthenopin:ab,ti OR glaucocarpine:ab,ti OR 'isopto carpine':ab,ti OR isoptopilocarpine:ab,ti OR liocarpina:ab,ti OR miocarpine:ab,ti OR 'ocu carpine':ab,ti OR ocucarpine:ab,ti OR pilagan:ab,ti OR pilasite:ab,ti OR pilocar:ab,ti OR pilocarpin:ab,ti OR pilocarpol:ab,ti OR pilofrin:ab,ti OR pilogel:ab,ti OR piloheptine:ab,ti OR pilomann:ab,ti OR pilomin:ab,ti OR pilomiotin:ab,ti OR pilopine:ab,ti OR pilostat:ab,ti OR pilosyst:ab,ti OR pilotonina:ab,ti OR sanpilo:ab,ti OR 'sno pilo':ab,ti OR spersacarpine:ab,ti OR vistacarpin:ab,ti OR vitacarpine:ab,ti OR zhenrui:ab,ti OR '148 72 1':ab,ti OR '54 71 7':ab,ti OR '92 13 7':ab,ti
#72 ((drug* OR medic* OR pharmacologic*) NEAR/3 (treat* OR therap* OR intervent*)):ab,ti
#73 #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 OR #54 OR #55 OR #56 OR #57 OR #58 OR #59 OR #60 OR #61 OR #62 OR #63 OR #64 OR #65 OR #66 OR #67 OR #68 OR #69 OR #70 OR #71 OR #72
#74 #42 AND #73
#75 #32 AND #74
Appendix 4. PubMed search strategy
1. ((randomized controlled trial[pt]) OR (controlled clinical trial[pt]) OR (randomised[tiab] OR randomized[tiab]) OR (placebo[tiab]) OR (drug therapy[sh]) OR (randomly[tiab]) OR (trial[tiab]) OR (groups[tiab])) NOT (animals[mh] NOT humans[mh])
2. (angle*[tw] AND closure*[tw])
3. (angle*[tw] AND close*[tw])
4. (Uncompensat*[tw] AND glaucoma*[tw])
5. (Narrow*[tw] AND angle*[tw])
6. (occlude*[tw] AND angle*[tw])
7. Acute glaucoma*[tw]
8. (APAC[tw] OR AACG[tw] OR PACG[tw] OR PACS[tw])
9. pupillary block glaucoma[tw]
10. #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9
11. ((beta*[tw] AND Block*[tw]) OR (beta*[tw] AND antagonist*[tw]) OR beta sympathicolytic*[tw] OR beta sympatholytic*[tw])
12. (Timolol*[tw] OR Timoptic[tw] OR Timoptol[tw] OR Timacar[tw] OR timogel[tw] OR timod[tw] OR timolabak[tw] OR droptimol[tw] OR "L‐714,465"[tw] OR L714465[tw] OR "MK‐950"[tw] OR MK950[tw] OR Optimol[tw] OR Blocadren[tw] OR "26839‐75‐8"[tw])
13. (Metipranolol*[tw] OR Methypranol[tw] OR Trimepranol[tw] OR Disorat[tw] OR "22664‐55‐7"[tw])
14. (Carteolol*[tw] OR carteabak[tw] OR fortinol[tw] OR "OPC‐1085"[tw] OR OPC1085[tw] OR "51781‐06‐7"[tw])
15. (Levobunolol*[tw] OR PMSLevobunolol[tw] OR Ultracortenol[tw] OR Vistagan[tw] OR "W‐6412A"[tw] OR W6412A[tw] OR AKBeta[tw] OR ApoLevobunolol[tw] OR Betagan[tw] OR Bunolol[tw] OR NovoLevobunolol[tw] OR "W‐7000A"[tw] OR W7000A[tw] OR "47141‐42‐4"[tw])
16. (Betaxolol*[tw] OR Kerlone[tw] OR Kerlon[tw] OR Oxodal[tw] OR "SL‐75212"[tw] OR SL75212[tw] OR "ALO‐1401‐02"[tw] OR ALO140102[tw] OR Betoptic[tw] OR Betoptima[tw] OR "63659‐18‐7"[tw])
17. (Prostaglandin*[tw] OR Prostanoid*[tw] OR "PG Analogs"[tw] OR dimethylprostaglandin[tw] OR methylprostaglandin[tw])
18. (latanoprost*[tw] OR PHXA41[tw] OR Xalatan[tw] OR PhXA34[tw] OR "130209‐82‐4"[tw])
19. (travoprost*[tw] OR Travatan[tw] OR "AL‐6221"[tw] OR AL6221[tw] OR "157283‐68‐6"[tw])
20. (bimatoprost*[tw] OR latisse[tw] OR Lumigan[tw] OR AGN192024[tw])
21. (unoprostone*[tw] OR "UF‐021"[tw] OR Rescula[tw] OR Eescula[tw] OR "69553‐75‐9"[tw])
22. (tafluprost*[tw] OR "AFP 168"[tw] OR AFP168[tw] OR "de 085"[tw] OR de085 [tw] OR taflotan[tw] OR tapros [tw] OR zioptan[tw] OR saflutan[tw] OR "209860‐87‐7"[tw])
23. (antihypertensive*[tw] OR "Anti Hypertensives"[tw] OR "Anti Hypertensive"[tw])
24. (Pilocarpin*[tw] OR Isoptocarpine[tw] OR Salagen[tw] OR Isopilocarpine[tw] OR Ocusert[tw] OR adsorbocarpine[tw] OR akarpine[tw] OR almocarpine[tw] OR asthenopin[tw] OR glaucocarpine[tw] OR "isopto carpine"[tw] OR isoptopilocarpine[tw] OR liocarpina[tw] OR miocarpine[tw] OR "ocu‐carpine"[tw] OR ocucarpine[tw] OR pilagan[tw] OR pilasite[tw] OR pilocar[tw] OR pilocarpol[tw] OR pilofrin[tw] OR pilogel[tw] OR piloheptine[tw] OR pilomann[tw] OR pilomin[tw] OR pilomiotin[tw] OR pilopine[tw] OR pilostat[tw] OR pilosyst[tw] OR pilotonina[tw] OR sanpilo[tw] OR "sno pilo"[tw] OR spersacarpine[tw] OR vistacarpin[tw] OR vitacarpine[tw] OR zhenrui[tw] OR "148‐72‐1"[tw] OR "54‐71‐7"[tw] OR "92‐13‐7"[tw])
25. ((drug*[tw] OR medic*[tw] OR pharmacologic*[tw]) AND (treat*[tw] OR therap*[tw] OR intervent*[tw]))
26. #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25
27. #10 AND #26
28. #1 AND #27
29. Medline[sb]
30. #28 NOT #29
Appendix 5. LILACS search strategy
("Glaucoma de Ángulo Cerrado" OR "Glaucoma de Ângulo Fechado" OR MH:C11.525.381.056$ OR (angle$ AND (closure$ OR close$ OR narrow$ OR occlude$)) OR (Uncompensat$ glaucoma$) OR (Acute glaucoma$) OR (pupillary block glaucoma$) OR APAC OR AACG OR PACG OR PACS) AND ("Adrenergic beta‐Antagonists" OR "Antagonistas Adrenérgicos beta" OR "beta‐Adrenergic Receptor Blockaders" OR "beta‐Adrenergic Blocking Agents" OR "Adrenergic beta‐Receptor Blockaders" OR MH:D27.505.519.625.050.200.200$ OR MH:D27.505.696.577.050.200.200$ OR Timolol OR MH:D02.033.100.624.915$ OR MH:D02.033.755.624.915$ OR MH:D02.092.063.624.915$ OR MH:D02.886.675.867.768$ OR MH:D03.383.129.708.867.768$ OR MH:D03.383.533.640.775$ OR Metipranolol OR Trimepranol OR MH:D02.033.100.624.698.542$ OR MH:D02.033.755.624.698.542$ OR MH:D02.092.063.624.698.542$ OR Carteolol OR MH:D02.033.100.624.698.207$ OR MH:D02.033.755.624.698.207$ OR MH:D02.092.063.624.698.207$ OR MH:D03.438.810.835.188$ OR Levobunolol OR MH:D02.033.100.624.698.115.500$ OR MH:D02.033.755.624.698.115.500$ OR MH:D02.092.063.624.698.115.500$ OR MH:D02.455.426.559.847.638.960.446.500$ OR MH:D04.615.638.960.446.500$ OR Betaxolol OR MH:D02.033.100.624.698.077$ OR MH:D02.033.755.624.698.077$ OR MH:D02.092.063.624.698.077$ OR Prostaglandin$ OR MH:D10.251.355.255.100.637$ OR MH:D10.251.355.255.550$ OR MH:D23.469.050.175.725$ OR Latanoprost OR travoprost OR bimatoprost OR unoprostone OR tafluprost OR Antihypertensive$ OR Antihipertensivos OR "Anti‐Hipertensivos" OR "Anti Hypertensives" OR "Anti Hypertensive" OR MH:D27.505.954.411.162$ OR Pilocarpin$ OR MH:D03.132.672$ OR Miotic$ OR MH:D27.505.696.663.050.495$)
Appendix 6. ClinicalTrials.gov search strategy
Angle closure glaucoma OR Acute glaucoma OR pupillary block glaucoma
Appendix 7. ICTRP search strategy
Angle closure glaucoma OR Acute glaucoma OR pupillary block glaucoma OR narrow‐angle glaucoma OR uncompensated glaucoma OR uncompensative glaucoma
