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Tumour bed boost radiotherapy for women after breast conserving surgery

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view the current version 06 November 2017

Appendices

Appendix 1. MEDLINE

1

randomized controlled trial.pt.

2

controlled clinical trial.pt.

3

randomized.ab.

4

placebo.ab.

5

Clinical Trials as Topic/

6

randomly.ab.

7

trial.ti.

8

(crossover or cross‐over).tw.

9

Pragmatic Clinical Trials as Topic/

10

pragmatic clinical trial.pt.

11

or/1‐10

12

exp Breast Neoplasms/

13

(breast adj6 cancer$).tw.

14

(breast adj6 neoplasm$).tw.

15

(breast adj6 carcinoma$).tw.

16

(breast adj6 tumo?r$).tw.

17

or/12‐16

18

exp Radiotherapy, Adjuvant/

19

(external beam and (radiation or radiotherapy or irradiation)).tw.

20

(three dimensional and (radiation or radiotherapy or irradiation)).tw.

21

(3D and (radiation or radiotherapy or irradiation)).tw.

22

(3‐D and (radiation or radiotherapy or irradiation)).tw.

23

(3D conformal and (radiation or radiotherapy or irradiation)).tw.

24

(3‐D conformal and (radiation or radiotherapy or irradiation)).tw.

25

(three dimensional conformal and (radiation or radiotherapy or irradiation)).tw.

26

(cobalt‐60 and (radiation or radiotherapy or irradiation)).tw.

27

(whole breast and (radiation or radiotherapy or irradiation)).tw.

28

exp Radiotherapy, Conformal/

29

Radiotherapy, Intensity‐Modulated/

30

exp brachytherapy/

31

exp radiotherapy, computer‐assisted/

32

exp radiotherapy, high‐energy/

33

exp radiotherapy, image‐guided/

34

bed boost.tw.

35

(interstitial and (radiation or radiotherapy or irradiation)).tw.

36

(electron and (radiation or radiotherapy or irradiation)).tw.

37

(photon and (radiation or radiotherapy or irradiation)).tw.

38

18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37

39

exp Mastectomy, Segmental/

40

lumpectomy.tw.

41

quadrantectomy.tw.

42

breast conserving surgery.tw.

43

breast conserving therapy.tw.

44

surgery.tw.

45

wide excision.tw.

46

39 or 40 or 41 or 42 or 43 or 44 or 45

47

11 and 17 and 38 and 46

48

Animals/ not Humans/

49

47 not 48

Appendix 2. EMBASE

  1. random* OR factorial* OR crossover* OR cross NEXT/1 over* OR placebo* OR (doubl* AND blind*) OR (singl* AND blind*) OR assign*OR allocat* OR volunteer* OR 'crossover procedure'/exp OR 'crossover procedure' OR 'double blind procedure'/exp OR 'double blind procedure' OR 'randomized controlled trial'/exp OR 'randomized controlled trial' OR 'single blind procedure'/exp OR 'single blind procedure'

  2. 'breast'/exp OR 'breast disease'/exp AND 'neoplasm'/exp OR 'breast tumor'/exp OR (breast* NEAR/5 neoplas*):ab,ti OR (breast*NEAR/5 cancer*):ab,ti OR (breast* NEAR/5 carcin*):ab,ti OR (breast* NEAR/5 tumo*):ab,ti OR (breast* NEAR/5 metasta*):ab,ti OR (breast* NEAR/5 malig*):ab,ti

  3. 'breast cancer'/exp OR 'breast cancer' OR 'breast neoplasm' OR 'breast carcinoma'/exp OR 'breast carcinoma' OR 'breast tumour' OR'breast tumor'/exp OR 'breast tumor'

  4. #2 OR #3

  5. 'radiotherapy adjuvant'/exp

  6. 'external beam' AND (radiation OR radiotherapy OR irradiation)

  7. 'three dimensional' AND (radiation OR radiotherapy OR irradiation)

  8. 3d AND (radiation OR radiotherapy OR irradiation)

  9. '3 d' AND (radiation OR radiotherapy OR irradiation)

  10. '3 d' AND conformal AND (radiation OR radiotherapy OR irradiation)

  11. 'three dimensional conformal radiation therapy'

  12. 'cobalt 60' AND (radiation OR radiotherapy OR irradiation)

  13. 'cobalt therapy'/exp

  14. 'external beam radiotherapy'/exp

  15. 'intensity modulated radiation therapy'/exp

  16. 'whole breast' AND (radiation OR radiotherapy OR irradiation)

  17. 'interstitial radiation'/exp

  18. 'brachytherapy'/exp OR brachyterapy

  19. 'computer assisted radiotherapy'/exp

  20. 'megavoltage radiotherapy'/exp

  21. 'image guided radiotherapy'/exp

  22. 'bed boost' AND (radiation OR radiotherapy OR irradiation)

  23. 'electron' AND (radiation OR radiotherapy OR irradiation)

  24. 'photon' AND (radiation OR radiotherapy OR irradiation)

  25. #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR#23 OR #24

  26. 'segmental mastectomy'/exp

  27. 'partial mastectomy'/exp OR lumpectomy

  28. quadrantectomy

  29. 'breast conserving surgery'

  30. 'breast conserving therapy'

  31. 'surgery'

  32. 'wide excision'

  33. #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32

  34. #1 AND #4 AND #25 AND #33

  35. #34 AND [humans]/lim AND [embase]/lim

Appendix 3. CENTRAL

  1. MeSH descriptor: [Breast Neoplasms] explode all trees

  2. breast near cancer*

  3. breast near neoplasm*

  4. breast near carcinoma*

  5. breast near tumour*

  6. breast near tumor*

  7. #1 or #2 or #3 or #4 or #5 or #6

  8. MeSH descriptor: [Radiotherapy, Adjuvant] explode all trees

  9. MeSH descriptor: [Radiotherapy, Conformal] explode all trees

  10. MeSH descriptor: [Radiotherapy, Intensity‐Modulated] explode all trees

  11. MeSH descriptor: [Brachytherapy] explode all trees

  12. radiation therapy

  13. external beam and (radiation or irradiation or radiotherapy)

  14. three dimension* and (radiation or irradiation or radiotherapy)

  15. 3 d and (radiation or irradiation or radiotherapy)

  16. 3‐d and (radiation or irradiation or radiotherapy)

  17. 3 d conformal and (radiation or irradiation or radiotherapy)

  18. 3‐d conformal and (radiation or irradiation or radiotherapy)

  19. cobalt‐60 and (radiation or irradiation or radiotherapy)

  20. bed boost and (radiation or irradiation or radiotherapy)

  21. whole breast and (radiation or irradiation or radiotherapy)

  22. interstitial and (radiation or irradiation or radiotherapy)

  23. electron and (radiation or irradiation or radiotherapy)

  24. photon and (radiation or irradiation or radiotherapy)

  25. #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24

  26. MeSH descriptor: [Mastectomy, Segmental] explode all trees

  27. lumpectomy

  28. quadrantectomy

  29. breast conserving surgery

  30. breast conserving therapy

  31. surgery

  32. wide excision

  33. #26 or #27 or #28 or #29 or #31 or #32

  34. #7 and #25 and #33

Appendix 4. WHO ICTRP

Basic Searches:

1. breast cancer AND tumour bed boost

2. breast cancer AND radiotherapy AND breast conserving surgery

3. breast cancer AND radiotherapy AND partial mastectomy

Advanced Searches:

1.

Title: Tumour bed boost radiotherapy for women with breast cancer

Recruitment Status: ALL

2.

Condition: breast cancer OR breast neoplasm

Intervention: (radiation OR irradiation OR radiotherapy) AND (breast conserving surgery OR breast conserving therapy OR partial mastectomy OR lumpectomy)

Recruitment Status: ALL

3.

Condition: breast cancer OR breast neoplasm

Intervention: bed boost AND (breast conserving surgery OR breast conserving therapy OR partial mastectomy OR lumpectomy)

Recruitment Status: ALL

4.

Condition: breast cancer OR breast neoplasm

Intervention: (cobalt‐60 OR brachytherapy OR interstitial therapy) AND (breast conserving surgery OR breast conserving therapy OR partial mastectomy OR lumpectomy)

Recruitment Status: ALL

Appendix 5. ClinicalTrials.gov

Basic Searches:

1. breast cancer AND tumour bed boost

2. breast cancer AND radiotherapy AND breast conserving surgery

3. breast cancer AND radiotherapy AND partial mastectomy

Advanced Searches:

1.

Title: Tumour bed boost radiotherapy for women with breast cancer

Recruitment: All Studies

Study Results: All Studies

Study Type: All Studies

Gender: All Studies

2.

Condition: breast cancer OR breast neoplasm

Intervention: (breast irradiation OR tumour bed boost OR tumour bed boost) AND (breast conserving surgery OR breast conserving therapy OR segmental mastectomy OR partial mastectomy OR lumpectomy)

Recruitment: All Studies

Study Results: All Studies

Study Type: All Studies

Gender: All Studies

3.

Condition: breast cancer OR breast neoplasm

Intervention: (external beam irradiation OR conformal irradiation OR cobalt‐60 OR intensity‐modulated irradiation) AND (breast conserving surgery OR breast conserving therapy OR segmental mastectomy OR partial mastectomy OR lumpectomy)

Recruitment: All Studies

Study Results: All Studies

Study Type: All Studies

Gender: All Studies

4.

Condition: breast cancer OR breast neoplasm

Intervention: (brachytherapy OR interstitial therapy OR heavy ion radiotherapy OR proton radiotherapy OR adjuvant radiotherapy) AND (breast conserving surgery OR breast conserving therapy OR segmental mastectomy OR partial mastectomy OR lumpectomy)

Recruitment: All Studies

Study Results: All Studies

Study Type: All Studies

Gender: All Studies