Fibrin‐based haemostatic agents for reducing blood loss in adult liver resection
Appendices
Appendix 1. Search strategies
| Database | Time span | Search strategy |
| The Cochrane Hepato‐Biliary Group Controlled Trials Register | Date will be given at review stage | ((topical AND (hemostatic OR haemostatic)) OR (fibrin AND seal*) OR TachoSil OR TachoComb OR Tisseel OR Beriplast OR Biocol OR EviCel OR Crosseal OR Hemaseel OR Quixil OR Bolheal OR ViGuard) AND (((liver OR hepatic) AND (surgery OR surgical OR resect* OR segmentectomy OR sectionectomy OR trisectionectomy OR lobectomy)) OR (hepatectomy OR hepatectomies OR hemihepatectomy OR hemi‐hepatectomy)) |
| The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library | Latest issue | ((topical AND (hemostatic OR haemostatic)) OR (fibrin AND seal*) OR TachoSil OR TachoComb OR Tisseel OR Beriplast OR Biocol OR EviCel OR Crosseal OR Hemaseel OR Quixil OR Bolheal OR ViGuard) AND (((liver OR hepatic) AND (surgery OR surgical OR resect* OR segmentectomy OR sectionectomy OR trisectionectomy OR lobectomy)) OR (hepatectomy OR hepatectomies OR hemihepatectomy OR hemi‐hepatectomy)) |
| PubMed | 1950 to the date of search | ((topical AND (hemostatic OR haemostatic)) OR (fibrin AND seal*) OR TachoSil OR TachoComb OR Tisseel OR Beriplast OR Biocol OR EviCel OR Crosseal OR Hemaseel OR Quixil OR Bolheal OR ViGuard) AND (((liver OR hepatic) AND (surgery OR surgical OR resect* OR segmentectomy OR sectionectomy OR trisectionectomy OR lobectomy)) OR (hepatectomy OR hepatectomies OR hemihepatectomy OR hemi‐hepatectomy)) |
| MEDLINE (Ovid SP) | 1948 to the date of search | (((topical and (hemostatic or haemostatic)) or (fibrin and seal*) or TachoSil or TachoComb or Tisseel or Beriplast or Biocol or EviCel or Crosseal or Hemaseel or Quixil or Bolheal or ViGuard) and (((liver or hepatic) and (surgery or surgical or resect* or segmentectomy or sectionectomy or trisectionectomy or lobectomy)) or (hepatectomy or hepatectomies or hemihepatectomy or hemi‐hepatectomy))).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, ps, rs, nm, an, ui] |
| EMBASE (via Ovid SP) | 1980 to the date of search | (((topical and (hemostatic or haemostatic)) or (fibrin and seal*) or TachoSil or TachoComb or Tisseel or Beriplast or Biocol or EviCel or Crosseal or Hemaseel or Quixil or Bolheal or ViGuard) and (((liver or hepatic) and (surgery or surgical or resect* or segmentectomy or sectionectomy or trisectionectomy or lobectomy)) or (hepatectomy or hepatectomies or hemihepatectomy or hemi‐hepatectomy))).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, ps, rs, nm, an, ui] |
| Science Citation Index Expanded (apps.isiknowledge.com) | 1900 to the date of search | TS=(((topical AND (hemostatic OR haemostatic)) OR (fibrin AND seal*) OR TachoSil OR TachoComb OR Tisseel OR Beriplast OR Biocol OR EviCel OR Crosseal OR Hemaseel OR Quixil OR Bolheal OR ViGuard) AND (((liver OR hepatic) AND (surgery OR surgical OR resect* OR segmentectomy OR sectionectomy OR trisectionectomy OR lobectomy)) OR (hepatectomy OR hepatectomies OR hemihepatectomy OR hemi‐hepatectomy))) |
| Anaesthetic techniques | Surgical techniques | Surgical instruments |
| Lowering venous pressure | Anatomical dissection | CUSA1 |
| Autologous transfusion | Hepatic inflow occlusion | RFA2 needle dissection |
| Antifibrinolytic agents | Ischaemic preconditioning | Monopolar Dissecting Sealer3 |
|
| Total vascular exclusion | Water jet dissection4 |
|
| In situ hypothermic perfusion | Argon beam coagulation |
| Harmonic scalpel5 | ||
| *Adapted from Berrevoet 2007. | ||
| Product name | Fibrinogen concentration (mg/mL) | Thrombin concentration (IU/mL) | Factor XIII concentration (U/mL) | Antifibrinolytic agent |
| Beriplast®P (CSL Behring, Germany) | 90 | 500 | 60 | Bovine aprotinin: 1000 KIU/mL |
| Biocol® (LFB, France) | 127 | 558 | 11 | Bovine aprotinin: 3000 KIU/mL |
| Bolheal® (Kaketsuken Pharmaceutical, Japan) | 80 | 250 | 75 | Bovine aprotinin: 1000 KIU/mL |
| Evicel® ‐ formerly Crosseal® (Omrix Biopharmaceuticals, Israel) | 70 | 1000 | None | None |
| Quixil® (Omrix Biopharmaceuticals, Israel) | 50 | 1000 | None | Tranexamic acid: 85 to 105 mg/mL |
| Tachosil® (Nycomed, Switzerland) | 5.5* | 2.0** | None | None |
| Tisseel® (Baxter, Austria) | 90 | 500 | 30 | Bovine aprotinin: 3000 KIU/mL |
| *mg/cm2. | ||||
