| Any combination of two or more drugs compared with placebo or other comparators, or both, for fibromyalgia |
| Patient or population: adults with fibromyalgia Settings: community Intervention: any combination of two or more drugs (note: our searches found nine combinations of drugs) Comparison: placebo and/or other comparators |
| Patient‐reported pain relief of 30% or greater | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Patient‐reported pain relief of 50% or greater | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Patient‐reported global impression of clinical change much or very much improved (moderate improvement) | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Any pain‐related outcome indicating some improvement | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Participants experiencing any adverse event | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Participants experiencing any serious adverse event | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| Withdrawals due to adverse events | No or insufficient data for analysis for any combination of drugs | Very low quality, as no data for analysis |
| GRADE Working Group grades of evidence
High quality: we are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of effect, but there is a possibility that it is substantially different
Low quality: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect
Very low quality: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect |
