Interleukin‐2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission
Appendices
Appendix 1. CENTRAL search strategy
| ID | Search |
| #1 | MeSH descriptor Leukemia, Myeloid, Acute explode all trees |
| #2 | MeSH descriptor Leukemia, Myeloid explode all trees |
| #3 | MeSH descriptor Acute Disease explode all trees |
| #4 | (#2 AND #3) |
| #5 | (acut* or akut* or agud* or aigu*) |
| #6 | (myelo* or mielo* or nonlympho* or myeloid* or myelocytic*) |
| #7 | Leukem* or leukaem* or leuc* |
| #8 | (#5 AND #6 AND #7) |
| #9 | (aml*) |
| #10 | (#1 OR #4 OR #8 OR #9) |
| #11 | MeSH descriptor interleukin 2 Receptor Protein, this term only |
| #12 | interleukin‐2 ra:ti,ab |
| #13 | interleukin 2 ra:ti,ab |
| #14 | IL‐2 ra:ti,ab |
| #15 | IL2 ra:ti,ab |
| #16 | IL 2 ra:ti,ab |
| #17 | Il‐b ra:ti,ab |
| #18 | Il b ra:ti,ab |
| #19 | TCGF ra:ti,ab |
| #20 | lymphokine ra:ti,ab |
| #21 | proleukin ra:ti,ab |
| #22 | mylotarg ra:ti,ab |
| #23 | ceplene ra:ti,ab |
| #24 | aldesleukin ra:ti,ab |
| #25 | (#11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24) |
| #26 | (#10 AND #25) |
Appendix 2. MEDLINE search strategy
| # | Search |
| 1 | exp LEUKEMIA, MYELOID, ACUTE/ |
| 2 | LEUKEMIA, MYELOID/ |
| 3 | ACUTE DISEASE/ |
| 4 | 2 and 3 |
| 5 | (acut$ or akut$ or agud$ or aigu$).tw,kf,ot. |
| 6 | ((myelo$ or mielo$ or nonlympho$ or myeloid$ or myelocytic$) and (leuk?em$ or leuc$)).tw,kf,ot |
| 7 | 5 and 6 |
| 8 | aml.tw,kf,ot. |
| 9 | 1 or 4 or 7 or 8 |
| 10 | Interleukin 2 Receptor Protein/ |
| 11 | (interleukin‐2 or interleukin 2) .tw. |
| 12 | (IL‐2 or IL2 or IL 2) .tw. |
| 13 | TCGF .tw. |
| 14 | lymphokine .tw. |
| 15 | (Il‐b or II b).tw. |
| 16 | (proleukin or aldesleukin or mylotarg or ceplene).tw. |
| 17 | or/ 10‐16 |
| 18 | randomised controlled trial.pt. |
| 19 | controlled clinical trial.pt. |
| 20 | randomized.ab. |
| 21 | placebo.ab. |
| 22 | clinical trials as topic.sh. |
| 23 | randomly.ab. |
| 24 | trial.ti. |
| 25 | or/18‐24 |
| 26 | humans.sh. |
| 27 | 25 and 26 |
| 28 | 9 and 17 and 27 |
Appendix 3. EMBASE search strategy
| ID | Search |
| #1 | exp ACUTE MYELOID LEUKEMIA/ |
| #2 | MYELOID LEUKEMIA/ |
| #3 | ACUTE DISEASE/ |
| #4 | 2 and 3 |
| #5 | (acut* or akut* or agud* or aigu*).tw. |
| #6 | (myelo* or mielo* or nonlympho* or myeloid* or myelocytic*).tw. |
| #7 | (leukem* or leukaem* or leuc*).tw. |
| #8 | 5 and 6 and 7 |
| #9 | aml.tw. |
| #10 | 1 or 4 or 8 or 9 |
| #11 | Recombinant Interleukin 2 Receptor Agent/ |
| #12 | (interleukin‐2 or interleukin 2).tw. |
| #13 | (IL‐2 or IL2 or IL 2) .tw. |
| #14 | TCGF .tw. |
| #15 | lymphokine .tw. |
| #16 | (Il‐b or II b).tw. |
| #17 | (proleukin or aldesleukin or mylotarg or ceplene).tw. |
| #18 | or/11‐17 |
| #19 | 10 and 18 |
| #20 | random$.ti,ab. |
| #21 | placebo$.ti,ab. |
| #22 | (doubl$ adj blind$).ti,ab. |
| #23 | (singl$ adj blind$).ti,ab. |
| #24 | assign$.ti,ab. |
| #25 | allocat$.ti,ab. |
| #26 | double blind procedure.sh. |
| #27 | randomised controlled trial.sh. |
| #28 | single blind procedure.sh. |
| #29 | or/20‐28 |
| #30 | 19 and 29 |
Appendix 4. LILACS search strategy
We will search the following terms:
acute myeloid leukemia
AML
interleukin 2 or interleukin‐2 or IL 2 or IL‐2 or or IL2
Appendix 5. CBM search strategy
| # | Search |
| 1 | acute myeloid leukaemia AND interleukin 2 |
| 2 | AML AND interleukin 2 |
| 3 | acute myeloid leukaemia AND IL 2 |
| 4 | AML AND IL 2 |
| 5 | acute myeloid leukaemia AND interleukin‐2 |
| 6 | AML AND interleukin‐2 |
| 7 | acute myeloid leukaemia AND IL‐2 |
| 8 | AML AND IL‐2 |
| 9 | acute myeloid leukaemia AND IL2 |
| 10 | acute myeloid leukaemia AND TCGF |
| 11 | acute myeloid leukaemia AND lymphokine |
| 12 | acute myeloid leukaemia AND (proleukin OR aldesleukin OR mylotarg OR ceplene) |
| 13 | AML AND IL2 |
| 14 | AML AND TCGF |
| 15 | AML AND lymphokine |
| 16 | AML AND (proleukin OR aldesleukin OR mylotarg OR ceplene) |
Appendix 6. metaRegister search strategy
1. acute myeloid leukemia AND Interleukin‐2
2. acute myeloid leukemia AND Interleukin 2
3. acute myeloid leukemia AND IL‐2
4. acute myeloid leukemia AND IL 2
5. AML AND Interleukin‐2
6. AML AND Interleukin 2
7. AML AND IL‐2
8. AML AND IL 2
9. acute myeloid leukaemia AND IL2
10. acute myeloid leukaemia AND TCGF
11. acute myeloid leukaemia AND lymphokine
12. acute myeloid leukaemia AND (proleukin OR aldesleukin OR mylotarg OR ceplene)
13. AML AND IL2
14. AML AND TCGF
15. AML AND lymphokine
16. AML AND (proleukin OR aldesleukin OR mylotarg OR ceplene)
