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Mayor consumo de fruta y vegetales para la prevención primaria de las enfermedades cardiovasculares

Appendices

Appendix 1. Search strategies

CENTRAL

#1 MeSH descriptor: [Fruit] explode all trees
#2 MeSH descriptor: [Citrus] explode all trees
#3 MeSH descriptor: [Vegetables] explode all trees
#4 fruit*
#5 vegetable*
#6 orange*
#7 apple*
#8 pear or pears
#9 grape or grapes
#10 banana*
#11 berry or berries
#12 citrus
#13 carrot*
#14 greens
#15 cabbage*
#16 brassica*
#17 blackberr*
#18 blueberr*
#19 cranberr*
#20 guava*
#21 kiwi*
#22 lingonberr*
#23 mango*
#24 melon*
#25 papaya*
#26 pineapple*
#27 raspberr*
#28 strawberr*
#29 tomato*
#30 potato*
#31 onion*
#32 grapefruit*
#33 mandarin*
#34 satsuma*
#35 tangerine*
#36 plum or plums
#37 apricot*
#38 cherry or cherries
#39 nectarine*
#40 peach or peaches
#41 celery
#42 spinach*
#43 salad or salads
#44 pea or peas
#45 bean or beans
#46 broccoli
#47 cauliflower*
#48 beetroot*
#49 turnip*
#50 rhubarb
#51 legume*
#52 cucumber*
#53 leek*
#54 aubergine*
#55 pepper*
#56 okra
#57 pumpkin*
#58 squash*
#59 artichoke*
#60 lettuce*
#61 kale
#62 chard
#63 parsnip*
#64 asparagus
#65 fennel
#66 chickpea*
#67 five‐a‐day
#68 5‐a‐day
#69 5 next a next day
#70 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10
#71 #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20
#72 #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30
#73 #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40
#74 #41 or #42 or #43 or #44 or #45 or #46 or #47 or #48 or #49 or #50
#75 #51 or #52 or #53 or #54 or #55 or #56 or #57 or #58 or #59 or #60
#76 #61 or #62 or #63 or #64 or #65 or #66 or #67 or #68 or #69
#77 #70 or #71 or #72 or #73 or #74 or #75 or #76
#78 MeSH descriptor: [Cardiovascular Diseases] explode all trees
#79 cardio*
#80 cardia*
#81 heart*
#82 coronary*
#83 angina*
#84 ventric*
#85 myocard*
#86 pericard*
#87 isch?em*
#88 emboli*
#89 arrhythmi*
#90 thrombo*
#91 atrial next fibrillat*
#92 tachycardi*
#93 endocardi*
#94 sick near sinus
#95 MeSH descriptor: [Stroke] explode all trees
#96 stroke or stokes
#97 cerebrovasc*
#98 cerebral next vascular
#99 apoplexy
#100 brain near/2 accident*
#101 brain* near/2 infarct*
#102 cerebral near/2 infarct*
#103 lacunar near/2 infarct*
#104 MeSH descriptor: [Hypertension] explode all trees
#105 hypertensi*
#106 peripheral next arter* next disease*
#107 high near/2 (blood next pressure)
#108 increased near/2 (blood next pressure)
#109 elevated near/2 (blood next pressure)
#110 MeSH descriptor: [Hyperlipidemias] explode all trees
#111 hyperlipid*
#112 hyperlip?emia*
#113 hypercholesterol*
#114 hypercholester?emia*
#115 hyperlipoprotein?emia*
#116 hypertriglycerid?emia*
#117 MeSH descriptor: [Arteriosclerosis] explode all trees
#118 MeSH descriptor: [Cholesterol] explode all trees
#119 cholesterol
#120 "coronary risk factor*"
#121 MeSH descriptor: [Blood Pressure] this term only
#122 blood pressure
#123 #78 or #79 or #80 or #81 or #82 or #83 or #84 or #85 or #86 or #87
#124 #88 or #89 or #90 or #91 or #92 or #93 or #94 or #95 or #96 or #97
#125 #98 or #99 or #100 or #101 or #102 or #103 or #104 or #105 or #106 or #107
#126 #108 or #109 or #110 or #111 or #112 or #113 or #114 or #115 or #116
#127 #117 or #118 or #119 or #120 or #121 or #122
#128 #123 or #124 or #125 or #126 or #127
#129 #77 and #128

MEDLINE OVID

1. exp Fruit/
2. exp Citrus/
3. exp Vegetables/
4. fruit*.tw.
5. vegetable*.tw.
6. orange*.tw.
7. apple*.tw.
8. (pear or pears).tw.
9. (grape or grapes).tw.
10. banana*.tw.
11. (berry or berries).tw.
12. citrus.tw.
13. carrot*.tw.
14. greens.tw.
15. cabbage*.tw.
16. brassica*.tw.
17. blackberr*.tw.
18. blueberr*.tw.
19. cranberr*.tw.
20. guava*.tw.
21. kiwi*.tw.
22. lingonberr*.tw.
23. mango*.tw.
24. melon*.tw.
25. papaya*.tw.
26. pineapple*.tw.
27. raspberr*.tw.
28. strawberr*.tw.
29. tomato*.tw.
30. potato*.tw.
31. onion*.tw.
32. grapefruit*.tw.
33. mandarin*.tw.
34. satsuma*.tw.
35. tangerine*.tw.
36. (plum or plums).tw.
37. apricot*.tw.
38. (cherry or cherries).tw.
39. nectarine*.tw.
40. (peach or peaches).tw.
41. celery.tw.
42. spinach*.tw.
43. (salad or salads).tw.
44. (pea or peas).tw.
45. (bean or beans).tw.
46. broccoli.tw.
47. cauliflower*.tw.
48. beetroot*.tw.
49. turnip*.tw.
50. rhubarb.tw.
51. legume*.tw.
52. cucumber*.tw.
53. leek*.tw.
54. aubergine*.tw.
55. pepper*.tw.
56. okra.tw.
57. pumpkin*.tw.
58. squash*.tw.
59. artichoke*.tw.
60. lettuce*.tw.
61. kale.tw.
62. chard.tw.
63. parsnip*.tw.
64. asparagus.tw.
65. fennel.tw.
66. chickpea*.tw.
67. five‐a‐day.tw.
68. 5‐a‐day.tw.
69. or/1‐68
70. exp Cardiovascular Diseases/
71. cardio*.tw.
72. cardia*.tw.
73. heart*.tw.
74. coronary*.tw.
75. angina*.tw.
76. ventric*.tw.
77. myocard*.tw.
78. pericard*.tw.
79. isch?em*.tw.
80. emboli*.tw.
81. arrhythmi*.tw.
82. thrombo*.tw.
83. atrial fibrillat*.tw.
84. tachycardi*.tw.
85. endocardi*.tw.
86. (sick adj sinus).tw.
87. exp Stroke/
88. (stroke or stokes).tw.
89. cerebrovasc*.tw.
90. cerebral vascular.tw.
91. apoplexy.tw.
92. (brain adj2 accident*).tw.
93. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
94. exp Hypertension/
95. hypertensi*.tw.
96. peripheral arter* disease*.tw.
97. ((high or increased or elevated) adj2 blood pressure).tw.
98. exp Hyperlipidemias/
99. hyperlipid*.tw.
100. hyperlip?emia*.tw.
101. hypercholesterol*.tw.
102. hypercholester?emia*.tw.
103. hyperlipoprotein?emia*.tw.
104. hypertriglycerid?emia*.tw.
105. exp Arteriosclerosis/
106. exp Cholesterol/
107. cholesterol.tw.
108. "coronary risk factor* ".tw.
109. Blood Pressure/
110. blood pressure.tw.
111. or/70‐110
112. randomized controlled trial.pt.
113. controlled clinical trial.pt.
114. randomized.ab.
115. placebo.ab.
116. drug therapy.fs.
117. randomly.ab.
118. trial.ab.
119. groups.ab.
120. 112 or 113 or 114 or 115 or 116 or 117 or 118 or 119
121. exp animals/ not humans.sh.
122. 120 not 121
123. 69 and 111 and 122

EMBASE OVID

1. exp fruit/
2. exp vegetable/
3. fruit*.tw.
4. vegetable*.tw.
5. orange*.tw.
6. apple*.tw.
7. (pear or pears).tw.
8. (grape or grapes).tw.
9. banana*.tw.
10. (berry or berries).tw.
11. citrus.tw.
12. carrot*.tw.
13. greens.tw.
14. cabbage*.tw.
15. brassica*.tw.
16. blackberr*.tw.
17. blueberr*.tw.
18. cranberr*.tw.
19. guava*.tw.
20. kiwi*.tw.
21. lingonberr*.tw.
22. mango*.tw.
23. melon*.tw.
24. papaya*.tw.
25. pineapple*.tw.
26. raspberr*.tw.
27. strawberr*.tw.
28. tomato*.tw.
29. potato*.tw.
30. onion*.tw.
31. grapefruit*.tw.
32. mandarin*.tw.
33. satsuma*.tw.
34. tangerine*.tw.
35. (plum or plums).tw.
36. apricot*.tw.
37. (cherry or cherries).tw.
38. nectarine*.tw.
39. (peach or peaches).tw.
40. celery.tw.
41. spinach*.tw.
42. (salad or salads).tw.
43. (pea or peas).tw.
44. (bean or beans).tw.
45. broccoli.tw.
46. cauliflower*.tw.
47. beetroot*.tw.
48. turnip*.tw.
49. rhubarb.tw.
50. legume*.tw.
51. cucumber*.tw.
52. leek*.tw.
53. aubergine*.tw.
54. pepper*.tw.
55. okra.tw.
56. pumpkin*.tw.
57. squash*.tw.
58. artichoke*.tw.
59. lettuce*.tw.
60. kale.tw.
61. chard.tw.
62. parsnip*.tw.
63. asparagus.tw.
64. fennel.tw.
65. chickpea*.tw.
66. five‐a‐day.tw.
67. 5‐a‐day.tw.
68. or/1‐67
69. exp cardiovascular disease/
70. cardio*.tw.
71. cardia*.tw.
72. heart*.tw.
73. coronary*.tw.
74. angina*.tw.
75. ventric*.tw.
76. myocard*.tw.
77. pericard*.tw.
78. isch?em*.tw.
79. emboli*.tw.
80. arrhythmi*.tw.
81. thrombo*.tw.
82. atrial fibrillat*.tw.
83. tachycardi*.tw.
84. endocardi*.tw.
85. (sick adj sinus).tw.
86. exp cerebrovascular disease/
87. (stroke or stokes).tw.
88. cerebrovasc*.tw.
89. cerebral vascular.tw.
90. apoplexy.tw.
91. (brain adj2 accident*).tw.
92. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
93. exp hypertension/
94. hypertensi*.tw.
95. peripheral arter* disease*.tw.
96. ((high or increased or elevated) adj2 blood pressure).tw.
97. exp hyperlipidemia/
98. hyperlipid*.tw.
99. hyperlip?emia*.tw.
100. hypercholesterol*.tw.
101. hypercholester?emia*.tw.
102. hyperlipoprotein?emia*.tw.
103. hypertriglycerid?emia*.tw.
104. exp Arteriosclerosis/
105. exp Cholesterol/
106. cholesterol.tw.
107. "coronary risk factor* ".tw.
108. Blood Pressure/
109. blood pressure.tw.
110. or/69‐109
111. random$.tw.
112. factorial$.tw.
113. crossover$.tw.
114. cross over$.tw.
115. cross‐over$.tw.
116. placebo$.tw.
117. (doubl$ adj blind$).tw.
118. (singl$ adj blind$).tw.
119. assign$.tw.
120. allocat$.tw.
121. volunteer$.tw.
122. crossover procedure/
123. double blind procedure/
124. randomized controlled trial/
125. single blind procedure/
126. 111 or 112 or 113 or 114 or 115 or 116 or 117 or 118 or 119 or 120 or 121 or 122 or 123 or 124 or 125
127. (animal/ or nonhuman/) not human/
128. 126 not 127
129. 68 and 110 and 128

Web of Science

#22 #21 AND #20
#21 TS=(random* or blind* or allocat* or assign* or trial* or placebo* or crossover* or cross‐over*)
#20 #19 AND #7
#19 #18 OR #17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11 OR #10 OR #9 OR #8
#18 TS=blood pressure
#17 TS="coronary risk factor*"
#16 TS=cholesterol
#15 TS=arteriosclerosis
#14 TS=(hyperlipid* OR hyperlip?emia* OR hypercholesterol* OR hypercholester?emia* OR hyperlipoprotein?emia* OR hypertriglycerid?emia*)
#13 TS=("high blood pressure")
#12 TS=(hypertensi* OR "peripheral arter* disease*")
#11 TS=(stroke OR stokes OR cerebrovasc* OR cerebral OR apoplexy OR (brain SAME accident*) OR (brain SAME infarct*))
#10 TS=("atrial fibrillat*" OR tachycardi* OR endocardi*)
#9 TS=(pericard* OR isch?em* OR emboli* OR arrhythmi* OR thrombo*)
#8 TS=(cardio* OR cardia* OR heart* OR coronary* OR angina* OR ventric* OR myocard*)
#7 #6 OR #5 OR #4 OR #3 OR #2 OR #1
#6 TS=(kale or chard or parsnip* or asparagus or fennel or chickpea* or five‐a‐day or "five a day" or 5‐a‐day or "5 a day")
#5 TS=(beetroot* or turnip* or rhubarb or legume* or cucumber* or leek* or aubergine* or pepper* or okra or pumpkin* or squash* or artichoke* or lettuce*)
#4 TS=(cherry or cherries or nectarine* or peach or peaches or celery or spinach* or salad or salads or pea or peas or bean or beans or broccoli or cauliflower*)
#3 TS=(pineapple* or raspberr* or strawberr* or tomato* or potato* or onion* or grapefruit* or mandarin* or satsuma* or tangerine* or plum or plums or apricot*)
#2 TS=(carrot* or greens or cabbage* or brassica* or blackberr* or blueberr* or cranberr* or guava* or kiwi* or lingonberr* or mango* or melon* or pap aya*)
#1 TS=(fruit* or vegetable* or orange* or apple* or pear or pears or grape or grapes or banana* or berry or berries or citrus)

Study flow diagram.

Figures and Tables -
Figure 1

Study flow diagram.

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

Figures and Tables -
Figure 2

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Figures and Tables -
Figure 3

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Comparison 1: Advice to eat fruit and vegetables, Outcome 1: Systolic blood pressure, change from baseline (mmHg)

Figures and Tables -
Analysis 1.1

Comparison 1: Advice to eat fruit and vegetables, Outcome 1: Systolic blood pressure, change from baseline (mmHg)

Comparison 1: Advice to eat fruit and vegetables, Outcome 2: Diastolic blood pressure, change from baseline (mmHg)

Figures and Tables -
Analysis 1.2

Comparison 1: Advice to eat fruit and vegetables, Outcome 2: Diastolic blood pressure, change from baseline (mmHg)

Comparison 1: Advice to eat fruit and vegetables, Outcome 3: Total cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 1.3

Comparison 1: Advice to eat fruit and vegetables, Outcome 3: Total cholesterol, change from baseline (mmol/l)

Comparison 1: Advice to eat fruit and vegetables, Outcome 4: LDL cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 1.4

Comparison 1: Advice to eat fruit and vegetables, Outcome 4: LDL cholesterol, change from baseline (mmol/l)

Comparison 1: Advice to eat fruit and vegetables, Outcome 5: HDL cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 1.5

Comparison 1: Advice to eat fruit and vegetables, Outcome 5: HDL cholesterol, change from baseline (mmol/l)

Comparison 1: Advice to eat fruit and vegetables, Outcome 6: Triglycerides, change from baseline (mmol/l)

Figures and Tables -
Analysis 1.6

Comparison 1: Advice to eat fruit and vegetables, Outcome 6: Triglycerides, change from baseline (mmol/l)

Comparison 2: Provision of fruit and vegetables, Outcome 1: Systolic blood pressure, change from baseline (mmHg)

Figures and Tables -
Analysis 2.1

Comparison 2: Provision of fruit and vegetables, Outcome 1: Systolic blood pressure, change from baseline (mmHg)

Comparison 2: Provision of fruit and vegetables, Outcome 2: Diastolic blood pressure, change from baseline (mmHg)

Figures and Tables -
Analysis 2.2

Comparison 2: Provision of fruit and vegetables, Outcome 2: Diastolic blood pressure, change from baseline (mmHg)

Comparison 2: Provision of fruit and vegetables, Outcome 3: Total cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 2.3

Comparison 2: Provision of fruit and vegetables, Outcome 3: Total cholesterol, change from baseline (mmol/l)

Comparison 2: Provision of fruit and vegetables, Outcome 4: LDL cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 2.4

Comparison 2: Provision of fruit and vegetables, Outcome 4: LDL cholesterol, change from baseline (mmol/l)

Comparison 2: Provision of fruit and vegetables, Outcome 5: HDL cholesterol, change from baseline (mmol/l)

Figures and Tables -
Analysis 2.5

Comparison 2: Provision of fruit and vegetables, Outcome 5: HDL cholesterol, change from baseline (mmol/l)

Comparison 2: Provision of fruit and vegetables, Outcome 6: Trigylcerides, change from baseline (mmol/l)

Figures and Tables -
Analysis 2.6

Comparison 2: Provision of fruit and vegetables, Outcome 6: Trigylcerides, change from baseline (mmol/l)

Comparison 1. Advice to eat fruit and vegetables

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1.1 Systolic blood pressure, change from baseline (mmHg) Show forest plot

2

891

Mean Difference (IV, Fixed, 95% CI)

‐3.00 [‐4.92, ‐1.09]

1.2 Diastolic blood pressure, change from baseline (mmHg) Show forest plot

2

891

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐2.03, 0.24]

1.3 Total cholesterol, change from baseline (mmol/l) Show forest plot

4

970

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.11, 0.09]

1.4 LDL cholesterol, change from baseline (mmol/l) Show forest plot

2

251

Mean Difference (IV, Fixed, 95% CI)

‐0.17 [‐0.38, 0.03]

1.5 HDL cholesterol, change from baseline (mmol/l) Show forest plot

2

251

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.10, 0.08]

1.6 Triglycerides, change from baseline (mmol/l) Show forest plot

3

280

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.06, 0.27]

Figures and Tables -
Comparison 1. Advice to eat fruit and vegetables
Comparison 2. Provision of fruit and vegetables

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

2.1 Systolic blood pressure, change from baseline (mmHg) Show forest plot

1

157

Mean Difference (IV, Fixed, 95% CI)

1.00 [0.45, 1.55]

2.2 Diastolic blood pressure, change from baseline (mmHg) Show forest plot

1

157

Mean Difference (IV, Fixed, 95% CI)

1.50 [1.18, 1.82]

2.3 Total cholesterol, change from baseline (mmol/l) Show forest plot

2

187

Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.24, 0.04]

2.4 LDL cholesterol, change from baseline (mmol/l) Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.5 HDL cholesterol, change from baseline (mmol/l) Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.6 Trigylcerides, change from baseline (mmol/l) Show forest plot

3

284

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.03, 0.01]

Figures and Tables -
Comparison 2. Provision of fruit and vegetables