Appendix 1. MEDLINE (OVID) search strategy

#1 CLEFT PALATE/
#2 CLEFT LIP/
#3 (cleft$ adj4 (lip or palate)).mp.
#4 ((alveolar or maxilla$ or gum$ or jaw$ or palat$ or lip$) adj6 (cleft$ or defect$ or malform$ or abnorm$)).mp.
#5 or/1‐4
#6 exp BONE TRANSPLANTATION/
#7 ((bone$ or bony or osseous$ or osteal$) adj6 (graft$ or surg$ or reconstruct$ or restor$ or implant$ or augment$ or repair$)).mp.
#8 osteoplast$.mp.
#9 or/6‐8
#10 5 and 9

This search strategy will be combined with the Cochrane Highly Sensitive Search Strategy for identifying randomised trials in MEDLINE: sensitivity maximising version (2008 revision) as referenced in Chapter 6.4.11.1 and detailed in box 6.4.c of the Cochrane Handbook for Systematic Reviews of Interventions version 5.0.1 (updated September 2008):
1. randomized controlled trial.pt.
2. controlled clinical trial.pt.
3. randomized.ab.
4. placebo.ab.
5. drug therapy.fs.
6. randomly.ab.
7. trial.ab.
8. groups.ab.
9. or/1‐8
10. animals.sh. not (humans.sh. and animals.sh.)
11. 9 not 10