Appendix 1. Search strategy for MEDLINE (PubMed)

Medical interventions:

1. ACE‐inhibitor

(ace inhibitor OR ace‐inhibitor OR ace inhibitor* OR ace‐inhibitor* OR Angiotensin‐Converting Enzyme Inhibitors OR Angiotensin‐Converting Enzyme Inhibitors[Pharmacological Action] OR Angiotensin Converting Enzyme Inhibitors OR Angiotensin‐Converting Enzyme Antagonists OR Angiotensin Converting Enzyme Antagonists OR Enzyme Antagonists, Angiotensin‐Converting OR Antagonists, Angiotensin‐Converting Enzyme OR Antagonists, Angiotensin Converting Enzyme OR Antagonists, Kininase II OR Inhibitors, Kininase II OR Inhibitors, ACE OR ACE Inhibitors OR Kininase II Inhibitors OR Kininase II Antagonists OR Angiotensin I‐Converting Enzyme Inhibitors OR Angiotensin I Converting Enzyme Inhibitors OR Inhibitors, Angiotensin‐Converting Enzyme OR Enzyme Inhibitors, Angiotensin‐Converting OR Inhibitors, Angiotensin Converting Enzyme OR Angiotensin‐Converting Enzyme Inhibitor* OR Angiotensin Converting Enzyme Inhibitor* OR Angiotensin‐Converting Enzyme Antagonist* OR Angiotensin Converting Enzyme Antagonist*  OR  Kininase II Inhibitor* OR Kininase II Antagonist* OR Angiotensin I‐Converting Enzyme Inhibitor* OR Angiotensin I Converting Enzyme Inhibitor* OR captopril OR enalapril OR fosinopril) OR (peptidyl dipeptidase OR Peptidyl Dipeptidase A OR Angiotensin I‐Converting Enzyme OR Angiotensin I Converting Enzyme OR Carboxycathepsin OR Kininase A OR CD143 Antigen OR CD143 Antigens OR Dipeptidyl Peptidase A OR Antigens, CD143 OR Angiotensin Converting Enzyme OR Kininase II)

2. Angiotensin receptor blocker

(angiotensin receptor blocker OR angiotensin receptor blockers OR angiotensin receptor blocker* OR Angiotensin II Type 1 Receptor Blockers OR Angiotensin II Type 1 Receptor Antagonists OR Type 1 Angiotensin Receptor Antagonists OR Type 1 Angiotensin Receptor Blockers OR Selective Angiotensin II Receptor Antagonists OR Sartans OR Angiotensin II OR Angiotensin Receptors/antagonists & inhibitors OR Angiotensin II Type 1 Receptor Blocker* OR  Type 1 Angiotensin Receptor Antagonist* OR Type 1 Angiotensin Receptor Blocker* OR Selective Angiotensin II Receptor Antagonist* OR losartan OR valsartan)

3. Beta‐blocker

(beta blocker OR beta blockers OR beta‐blockers OR beta‐blocker OR beta‐blocker* OR beta blocker* OR Adrenergic beta Antagonists OR adrenergic beta‐antagonists OR adrenergic beta‐antagonists[Pharmacological Action] OR beta‐Antagonists, Adrenergic OR Adrenergic beta‐Receptor Blockaders OR Adrenergic beta Receptor Blockaders OR Blockaders, Adrenergic beta‐Receptor OR beta‐Receptor Blockaders, Adrenergic OR beta‐Adrenergic Receptor Blockaders OR Blockaders, beta‐Adrenergic Receptor OR Receptor Blockaders, beta‐Adrenergic OR beta Adrenergic Receptor Blockaders OR beta‐Adrenergic Blocking Agents OR Agents, beta‐Adrenergic Blocking OR Blocking Agents, beta‐Adrenergic OR beta Adrenergic Blocking Agents OR beta‐Adrenergic Blockers OR Blockers, beta‐Adrenergic OR beta Adrenergic Blockers OR beta‐Blockers, Adrenergic OR Adrenergic beta‐Blockers OR beta Blockers, Adrenergic OR Sympatholytics OR Sympatholytics[Pharmacological Action] OR Sympathetic‐Blocking Agents OR Agents, Sympathetic‐Blocking OR Sympathetic Blocking Agents OR Sympatholytic Agents OR Agents, Sympatholytic OR Sympatholytic Drugs OR Drugs, Sympatholytic OR Sympatholytic* OR Adrenergic beta Antagonist* OR Adrenergic beta‐Receptor Blockader* OR Adrenergic beta Receptor Blockader* OR beta‐Adrenergic Receptor Blockader* OR beta Adrenergic Receptor Blockader* OR beta‐Adrenergic Blocking Agent* OR beta Adrenergic Blocking Agent* OR beta Adrenergic Blocker* OR beta‐Adrenergic Blocker* OR Adrenergic beta‐Blocker* OR Sympathetic‐Blocking Agent* OR Sympathetic Blocking Agent* OR Sympatholytic Agent* OR Sympatholytic Drug* OR carvedilol OR atenolol OR metoprolol OR propranolol)

4. Calcium channel blocker

(calcium channel blocker OR calcium channel blockers OR calcium channel blockers[Pharmacological Action] OR calcium channel blocker* OR Exogenous Calcium Antagonists OR Antagonists, Exogenous Calcium OR Calcium Antagonists, Exogenous OR Exogenous Calcium Blockaders OR Blockaders, Exogenous Calcium OR Calcium Inhibitors, Exogenous OR Calcium Channel Blocking Drugs OR Exogenous Calcium Inhibitors OR Inhibitors, Exogenous Calcium OR Calcium Blockaders, Exogenous OR Channel Blockers, Calcium OR Blockers, Calcium Channel OR Exogenous Calcium Antagonist* OR Exogenous Calcium Blockader* OR Calcium Channel Blocking Drug* OR Exogenous Calcium Inhibitor* OR Exogenous Calcium Blockader* OR Calcium Channel Blocking Drug* OR Exogenous Calcium Inhibitor* OR diltiazem OR nifedipine)

5. Digoxin

(digoxin OR digoxin* OR Lanoxin)

6. Vasodilator agent

(vasodilator OR vasodilators OR vasodilator* OR vasodilator agents OR vasodilator agents[Pharmacological Action] OR Agents, Vasodilator OR Vasodilator Drugs OR Drugs, Vasodilator OR Vasoactive Antagonists OR Antagonists, Vasoactive OR Vasoactive Antagonist* OR vasodilator agent* OR Vasodilator Drug* OR nitroglycerin OR Glyceryl Trinitrate OR Trinitrate, Glyceryl OR Nitroglycerin* OR diazoxide OR adenosine)

7. Diuretic

(diuretic OR diuretics OR diuretic* OR diuretics[Pharmacological Action] OR furosemide )

8. Aldosterone antagonist

(aldosteron antagonist OR aldosteron antagonists OR aldosterone antagonist OR aldosterone antagonists OR aldosterone antagonist* OR aldosteron antagonist* OR "Aldosterone antagonists"[Pharmacological Action] OR Antagonists, Aldosterone OR spironolactone)

9. (Other) antihypertensive agents

(antihypertensiva OR anti‐hypertensive OR anti hypertensive OR anti hypertensive drugs OR antihypertensive drugs OR antihypertensive agents OR antihypertensive agents[Pharmacological Action] OR Agents, Antihypertensive OR Anti‐Hypertensive Agents OR Agents, Anti‐Hypertensive OR Anti Hypertensive Agents OR Anti‐Hypertensive Drugs OR Anti Hypertensive Drugs OR Drugs, Anti‐Hypertensive OR Anti‐Hypertensives OR Anti Hypertensives OR Antihypertensive Drugs OR Drugs, Antihypertensive OR Antihypertensives OR antihypertensiv* OR antihypertensive drug* OR anti hypertensive drug* OR antihypertensive agent* OR anti hypertensive agent* OR clonidine)

10. Inotropic

(inotropics OR inotropic OR inotropic* OR dopamine OR dobutamine OR epinephrine OR norepinephrine)

11. Growth hormone

(growth hormone OR Growth Hormone, Pituitary OR Pituitary Growth Hormone OR Somatotropin OR Growth Hormone, Recombinant OR Growth Hormones Pituitary, Recombinant OR Pituitary Growth Hormones, Recombinant OR Recombinant Pituitary Growth Hormones OR Somatotropin, Recombinant OR Recombinant Somatotropin OR Recombinant Growth Hormone OR Recombinant Growth Hormones OR Growth Hormones, Recombinant OR Recombinant Somatotropins OR Somatotropins, Recombinant OR growth hormon* OR Somatotropin* OR Pituitary Growth Hormon* OR Recombinant Pituitary Growth Hormon* OR Recombinant Somatotropin* OR Recombinant Growth Hormon*)

Total search strategy for medical interventions:

12. 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11

13. Anthracyclines

(anthracyclines OR anthracyclin* OR anthracycline antibiotics OR antibiotics, anthracycline OR 4‐demethoxydaunorubicin OR 4 demethoxydaunorubicin OR 4‐desmethoxydaunorubicin OR 4 desmethoxydaunorubicin OR IMI 30 OR IMI30 OR IMI‐30 OR idarubicin hydrochloride OR hydrochloride, idarubicin OR NSC 256439 OR NSC‐256439 OR NSC256439 OR idarubicin OR idarubic* OR 4'‐epiadriamycin OR 4' epiadriamycin OR 4'‐epidoxorubicin OR 4' epidoxorubicin OR 4'‐epi‐doxorubicin OR 4' epi doxorubicin OR 4'‐epi‐adriamycin OR 4' epi adriamycin OR 4'‐epi‐DXR OR 4' epi DXR OR epirubicin hydrochloride OR hydrochloride, epirubicin OR farmorubicin OR IMI‐28 OR IMI 28 OR IMI28 OR NSC 256942 OR NSC‐256942 OR NSC256942 OR epirubicin OR epirubic* OR adriablastine OR adriblastin OR adriablastin OR adriamycin OR DOX‐SL OR DOX SL OR doxorubicin hydrochloride OR hydrochloride, doxorubicin OR doxorubic* OR adriamyc* OR dauno‐rubidomycine OR dauno rubidomycin OR rubidomycin OR rubomycin OR daunomycin OR cerubidine OR daunoblastin OR daunoblastine OR daunorubicin hydrochloride OR hydrochloride, daunorubicin OR daunorubic* OR rubidomyc* OR NSC‐82151 OR NSC 82151 OR NSC82151 OR daunoxome OR daunoxom* OR daunosom* OR doxil OR caelyx OR liposomal doxorubicin OR doxorubicin, liposomal OR myocet OR doxorubicin OR daunorubicin)

14. Childhood cancer

(((leukemia OR leukemi* OR leukaemi* OR (childhood ALL) OR AML OR lymphoma OR lymphom* OR hodgkin* OR T‐cell OR B‐cell OR non‐hodgkin OR sarcoma OR sarcom* OR sarcoma, Ewing's OR Ewing* OR osteosarcoma OR osteosarcom* OR wilms tumor OR wilms* OR nephroblastom* OR neuroblastoma OR neuroblastom* OR rhabdomyosarcoma OR rhabdomyosarcom* OR teratoma OR teratom* OR hepatoma OR hepatom* OR hepatoblastoma OR hepatoblastom* OR PNET OR medulloblastoma OR medulloblastom* OR PNET* OR neuroectodermal tumors, primitive OR retinoblastoma OR retinoblastom* OR meningioma OR meningiom* OR glioma OR gliom*) OR (pediatric oncology OR paediatric oncology)) OR (childhood cancer OR childhood tumor OR childhood tumors)) OR (cancer or neoplasms or tumor or cancers or neoplasm or tumors)

15. RCTs, CCTs

(randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug therapy[sh] OR randomly[tiab] OR trial[tiab] OR groups[tiab]) AND humans[mh]

The final combined search will be:

17. 12 AND 13 AND 14 AND 15

Appendix 2. Search strategy for EMBASE (OVID)

1. Medical interventions

1. (ace inhibitor or ace‐inhibitor or ace inhibitor$ or ace‐inhibitor$).mp.
2. Dipeptidyl Carboxypeptidase Inhibitor/ or (angiotensin converting enzyme inhibitor or angiotensin converting enzyme inhibitors or angiotensin converting enzyme inhibitor$).mp.
3. (angiotensin‐converting enzyme inhibitor or angiotensin‐converting enzyme inhibitors or angiotensin‐converting enzyme inhibitor$).mp.
4. (angiotensin‐converting enzyme antagonist or angiotensin‐converting enzyme antagonists or angiotensin‐converting enzyme antagonist$ or angiotensin converting enzyme antagonist or angiotensin converting enzyme antagonists or angiotensin converting enzyme antagonist$).mp.
5. (kininase II inhibitor or kininase II inhibitors or kininase II inhibitor$ or kininase II antagonist or kininase antagonists or kininase antagonist$).mp.
6. (angiotensin I‐converting enzyme inhibitors or angiotensin I converting enzyme inhibitors or angiotensin I‐converting enzyme inhibitor$ or angiotensin I converting enzyme inhibitor$).mp.
7. (peptidyl dipeptidase or peptidyl dipeptidase A).mp. or exp Dipeptidyl Carboxypeptidase/
8. exp Kininase/ or Kininase A.mp.
9. (Angiotensin I‐Converting Enzyme or Angiotensin I Converting Enzyme).mp.
10. exp Dipeptidyl Peptidase/ or Dipeptidyl Peptidase A.mp.
11. (Carboxycathepsin or Angiotensin Converting Enzyme or Kininase II).mp.
12. (CD143 Antigen or CD143 Antigens).mp.
13. (captopril or enalapril or fosinopril).mp. or exp Captopril Plus Hydrochlorothiazide/ or exp Captopril/ or exp Enalapril Maleate/ or exp Enalapril Plus Hydrochlorothiazide/ or exp Enalapril/ or exp Enalapril Maleate Plus Nitrendipine/ or exp Enalapril Maleate Plus Felodipine/ or exp Diltiazem Plus Enalapril Maleate/ or exp Fosinopril/ [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]
14. (angiotensin receptor blocker or angiotensin receptor blockers or angiotensin receptor blocker$).mp.
15. (angiotensin II type 1 receptor blockers or angiotensin II type 2 receptor blocker$).mp. or exp Angiotensin Receptor Antagonist/
16. (angiotensin II type 1 receptor antagonists or type 1 angiotensin receptor antagonists or type 1 angiotensin receptor blocker$ or type 1 angiotensin receptor blockers or type 1 angiotensin receptor antagonist$).mp.
17. exp Angiotensin Antagonist/ or exp Angiotensin/ or exp Angiotensin 2 Receptor Antagonist/ or exp Angiotensin II Antagonist/
18. (selective angiotensin II receptor antagonists or selective angiotensin II receptor antogonist$ or sartans or angiotensin II).mp.
19. (losartan or valsartan).mp. or exp Losartan/ or exp Hydrochlorothiazide Plus Losartan/ or exp Losartan Potassium/ or exp Hydrochlorothiazide Plus Valsartan/ or exp Amlodipine Plus Valsartan/ or exp Valsartan/
20. (beta blocker or beta blockers or beta blocker$ or beta‐blocker or beta‐blockers or beta‐blocker$).mp.
21. exp Beta Adrenergic Receptor Blocking Agent/
22. (adrenergic beta‐antagonists or adrenergic beta antagonists).mp.
23. (adrenergic beta‐receptor blockaders or adrenergic beta receptor blockaders or beta‐adrenergic receptor blockaders or beta adrenergic receptor blockaders).mp.
24. (beta‐adrenergic blocking agents or beta adregenic blocking agents or beta‐adrenergic blockers or beta adrenergic blockers or adrenergic beta‐blockers or adrenergic beta blockers).mp.
25. (sympatholytics or sympathetic‐blocking agents or sympathetic blocking agents or sympatholytic agents or sympatholytic drugs or sympatholytic$).mp.
26. (adrenergic beta antagonist$ or adrenergic beta‐receptor blockader$ or adrenergic beta receptor blockader$ or beta‐adrenergic receptor blockader$ or beta adrenergic receptor blockader$ or beta‐adrenergic blocking agent$ or beta adrenergic blocking agent$).mp.
27. (beta adrenergic blocker$ or beta‐adrenergic blocker$ or adrenergic beta‐blocker$ or sympathetic‐blocking agent$ or sympathetic blocking agent$ or sympatholytic agent$ or sympatholytic drug$).mp.
28. (carvedilol or atenolol or metoprolol or propanolol).mp. or exp carvedilol/ or exp atenolol plus chlortalidone/ or exp atenolol/ or exp atenolol plus nifedipine/ or exp metoprolol tartrate/ or exp metoprolol/ or exp metoprolol fumarate/ or exp metoprolol succinate/ or exp propranolol/
29. (calcium channel blocker or calcium channel blockers or calcium channel blocker$).mp.
30. exp Calcium Channel Blocking Agent/
31. exp Calcium Antagonist/ or (exogenous calcium antagonists or exogenous calcium blockaders or calcium channel blocking drugs).mp.
32. (exogenous calcium inhibitors or exogenous calcium antagonist$ or exogenous calcium blockader$ or calcium channel blocking drug$).mp.
33. (exogenous calcium inhibitor$ or exogenous calcium blockader$ or calcium channel blocking drug$ or exogenous calcium inhibitor$).mp.
34. exp Diltiazem Derivative/ or exp Diltiazem/ or exp Diltiazem Plus Enalapril Maleate/ or exp Nefedipine/ or (diltiazem or nefedipine).mp.
35. exp DIGOXIN/
36. (digoxin or digoxin$ or lanoxin).mp.
37. (vasodilator or vasodilators or vasodilator$).mp.
38. exp Vasodilator Agent/ or (vasodilator agents or vasodilator agent$ or vasodilator drugs or vasodilator drug$ or vasoactive antagonists or vasoactive antagonist$).mp.
39. (nitroglycerin or glyceryl trinitrate or nitroglycerin$ or diazoxide or adenosine).mp.
40. exp diazoxide/ or exp glyceryl trinitrate/
41. (diuretic or diuretics or diuretic$).mp.
42. exp Diuretic Agent/ or exp Furosemide Plus Triamterene/ or exp Furosemide/ or furosemide.mp.
43. (aldosteron antagonist or aldosteron antagonists or aldosterone antagonist aldosterone antagonists or aldosterone antagonist$).mp.
44. exp Aldosterone Antagonist/ or spironolacton.mp. or exp Spironolactone/
45. (antihypertensiva or antihypertensive or anti hypertensive or anti‐hypertensive).mp.
46. exp Antihypertensive Agent/
47. (anti hypertensive drugs or anti‐hypertensive drugs or antihypertensive drugs or antihypertensive agents or anti‐hypertensive agents or anti hypertensive agents).mp.
48. (anti‐hypertensives or anti hypertensives or antihypertensives).mp.
49. (antihypertensiv$ or antihypertensive drug$ or anti hypertensive drug$ or antihypertensive agent$ or anti hypertensive agent$).mp.
50. exp Clonidine Derivative/ or clonidine.mp. or exp Clonidine/ or exp Clonidine Displacing Substance/
51. (inotropic or inotropics or inotropic$).mp.
52. exp dopamine/ or exp dobutamine/ or exp adrenalin/ or exp noradrenaline/ or (dopamine or dobutamine or epinephrine or norepinephrine).mp.
53. (growth hormone or pituitary growth hormone).mp. or exp Growth Hormone/
54. (somatropin or recombinant somatotropin).mp. or exp recombinant growth hormone/ or recombinant pituitary growth hormones.mp.
55. (recombinant growth hormone or recombinant growth hormones or recombinant somatotropins).mp.
56. (growth hormon$ or somatotropin$ or pituitary growth hormon$ or recombinant pituitary growth hormon$ or recombinant somatotropin$ or recombinant growth hormon$).mp.
57. or/1‐56

2. Anthracyclines

1. (anthracyclin$ or anthracyclines).mp. or exp Anthracycline/
2. anthracycline antibiotics.mp. or exp Anthracycline Antibiotic Agent/
3. exp Anthracycline Derivative/
4. (4‐demethoxydaunorubicin or 4 demethoxydaunorubicin or 4‐desmethoxydaunorubicin or 4 desmethoxydaunorubicin).mp. or exp idarubicin/
5. (IMI 30 or IMI30 OR IMI‐30 or idarubicin hydrochloride).mp.
6. (NSC 256439 or NSC‐256439 or NSC256349 or idarubicin or idarubic$).mp.
7. (4'‐epiadriamycin or 4' epiadriamycin or 4'‐epidoxorubicin or 4' epidoxorubicin or 4'‐epi‐doxorubicin or 4' epi doxorubicin).mp.
8. (4'‐epi‐adriamycin or 4' epi adriamycin or 4'‐epi‐DXR or 4' epi DXR).mp.
9. exp epirubicin/ or (epirubicin or epirubicin hydrochloride or epirubic$ or farmorubicin).mp.
10. (IMI‐28 or IMI 28 or IMI28 or NSC 256942 or NSC‐256942 or NSC256942).mp.
11. (adriablastine or adriblastin or adriablastin or adriamycin).mp.
12. (DOX‐SL or DOX SL or doxorubicin hydrochloride or doxorubic$ or adramyc$).mp.
13. (dauno‐rubidomycine or dauno rubidomycin or rubidomycin or rubomycin or daunomycin).mp.
14. (cerubidine or daunoblastin or daunoblastine or daunorubicin hydrochloride or daunorubic$).mp.
15. (NSC‐82151 or NSC 82151 or NSC82151).mp.
16. (daunoxome or daunoxom$ or daunosom$ or doxil or caelyx or liposomal doxorubicin or myocet or doxorubicin or daunorubicin).mp.
17. exp DAUNORUBICIN DERIVATIVE/ or exp DAUNORUBICIN/ or exp IDARUBICIN DERIVATIVE/ or exp IDARUBICIN/ or exp DOXORUBICIN DERIVATIVE/ or exp DOXORUBICIN/ or exp EPIRUBICIN/
18. or/1‐17

3. Childhood cancer

1. (leukemia or leukemi$ or leukaemi$ or (childhood adj ALL) or acute lymphocytic leukemia).mp.

2. (AML or lymphoma or lymphom$ or hodgkin or hodgkin$ or T‐cell or B‐cell or non‐hodgkin).mp.

3. (sarcoma or sarcom$ or Ewing$ or osteosarcoma or osteosarcom$ or wilms tumor or wilms$).mp.

4. (nephroblastom$ or neuroblastoma or neuroblastom$ or rhabdomyosarcoma or rhabdomyosarcom$ or teratoma or teratom$ or hepatoma or hepatom$ or hepatoblastoma or hepatoblastom$).mp.

5. (PNET or medulloblastoma or medulloblastom$ or PNET$ or neuroectodermal tumors or primitive neuroectodermal tumor$ or retinoblastoma or retinoblastom$ or meningioma or meningiom$ or glioma or gliom$).mp.

6. (pediatric oncology or paediatric oncology).mp.

7. ((childhood adj cancer) or (childhood adj tumor) or (childhood adj tumors) or childhood malignancy or (childhood adj malignancies) or childhood neoplasm$).mp.

8. ((pediatric adj malignancy) or (pediatric adj malignancies) or (paediatric adj malignancy) or (paediatric adj malignancies)).mp.

9. ((brain adj tumor$) or (brain adj tumour$) or (brain adj neoplasms) or (brain adj cancer$) or brain neoplasm$).mp.

10. (central nervous system tumor$ or central nervous system neoplasm or central nervous system neoplasms or central nervous system tumour$).mp.

11. intracranial neoplasm$.mp.

12. LEUKEMIA/ or LYMPHOMA/ or brain tumor/ or central nervous system tumor/ or teratoma/ or sarcoma/ or osteosarcoma/

13. nephroblastoma/ or neuroblastoma/ or rhabdomyosarcoma/ or hepatoblastoma/ or medulloblastoma/ or neuroectodermal tumor/ or retinoblastoma/ or meningioma/ or glioma/ or childhood cancer/

14. or/1‐13

4. RCTs, CCTs

1. Randomized Controlled Trial/
2. Controlled Clinical Trial/
3. randomized.ti,ab.
4. placebo.ti,ab.
5. randomly.ti,ab.
6. trial.ti,ab.
7. groups.ti,ab.
8. drug therapy.sh.
9. or/1‐8
10. Human/
11. 9 and 10

The final combined search will be: 1 AND 2 AND 3 AND 4

[mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

Appendix 3. Search strategy for Central Register of Controlled Trials (CENTRAL)

Medical interventions:

1. ACE‐inhibitor

(ace inhibitor OR ace‐inhibitor OR ace inhibitor* OR ace‐inhibitor* OR Angiotensin‐Converting Enzyme Inhibitors OR Angiotensin Converting Enzyme Inhibitors OR Angiotensin‐Converting Enzyme Antagonists OR Angiotensin Converting Enzyme Antagonists OR ACE Inhibitors OR Kininase II Inhibitors OR Kininase II Antagonists OR Angiotensin I‐Converting Enzyme Inhibitors OR Angiotensin I Converting Enzyme Inhibitors OR Angiotensin‐Converting Enzyme Inhibitor* OR Angiotensin Converting Enzyme Inhibitor* OR Angiotensin‐Converting Enzyme Antagonist* OR Angiotensin Converting Enzyme Antagonist* OR Kininase II Inhibitor* OR Kininase II Antagonist* OR Angiotensin I‐Converting Enzyme Inhibitor* OR Angiotensin I Converting Enzyme Inhibitor* OR captopril OR enalapril OR fosinopril OR peptidyl dipeptidase OR Peptidyl Dipeptidase A OR Angiotensin I‐Converting Enzyme OR Angiotensin I Converting Enzyme OR Carboxycathepsin OR Kininase A OR CD143 Antigen OR CD143 Antigens OR Dipeptidyl Peptidase A OR Angiotensin Converting Enzyme OR Kininase II)

2. Angiotensin receptor blocker

(angiotensin receptor blocker OR angiotensin receptor blockers OR angiotensin receptor blocker* OR Angiotensin II Type 1 Receptor Blockers OR Angiotensin II Type 1 Receptor Antagonists OR Type 1 Angiotensin Receptor Antagonists OR Type 1 Angiotensin Receptor Blockers OR Selective Angiotensin II Receptor Antagonists OR Sartans OR Angiotensin II OR Angiotensin Receptors/antagonists & inhibitors OR Angiotensin II Type 1 Receptor Blocker* OR Type 1 Angiotensin Receptor Antagonist* OR Type 1 Angiotensin Receptor Blocker* OR Selective Angiotensin II Receptor Antagonist* OR losartan OR valsartan)

3. Beta‐blocker

(beta blocker OR beta blockers OR beta‐blockers OR beta‐blocker OR beta‐blocker* OR beta blocker* OR Adrenergic beta Antagonists OR adrenergic beta‐antagonists OR Adrenergic beta‐Receptor Blockaders OR Adrenergic beta Receptor Blockaders OR beta‐Adrenergic Receptor Blockaders OR beta Adrenergic Receptor Blockaders OR beta‐Adrenergic Blocking Agents OR beta Adrenergic Blocking Agents OR beta‐Adrenergic Blockers OR beta Adrenergic Blockers OR Adrenergic beta‐Blockers OR Sympatholytics OR Sympathetic‐Blocking Agents OR Sympathetic Blocking Agents OR Sympatholytic Agents OR Sympatholytic Drugs OR Sympatholytic* OR Adrenergic beta Antagonist* OR Adrenergic beta‐Receptor Blockader* OR Adrenergic beta Receptor Blockader* OR beta‐Adrenergic Receptor Blockader* OR beta Adrenergic Receptor Blockader* OR beta‐Adrenergic Blocking Agent* OR beta Adrenergic Blocking Agent* OR beta Adrenergic Blocker* OR beta‐Adrenergic Blocker* OR Adrenergic beta‐Blocker* OR Sympathetic‐Blocking Agent* OR Sympathetic Blocking Agent* OR Sympatholytic Agent* OR Sympatholytic Drug* OR carvedilol OR atenolol OR metoprolol OR propranolol)

4. Calcium channel blocker

(calcium channel blocker OR calcium channel blockers OR calcium channel blocker* OR Exogenous Calcium Antagonists OR Exogenous Calcium Blockaders OR Calcium Channel Blocking Drugs OR Exogenous Calcium Inhibitors OR Exogenous Calcium Antagonist* OR Exogenous Calcium Blockader* OR Calcium Channel Blocking Drug* OR Exogenous Calcium Inhibitor* OR Exogenous Calcium Blockader* OR Calcium Channel Blocking Drug* OR Exogenous Calcium Inhibitor* OR diltiazem OR nifedipine)

5. Digoxin

(digoxin OR digoxin* OR Lanoxin)

6. Vasodilator agent

(vasodilator OR vasodilators OR vasodilator* OR vasodilator agents OR Vasodilator Drugs OR Vasoactive Antagonists OR Vasoactive Antagonist* OR vasodilator agent* OR Vasodilator Drug* OR nitroglycerin OR Glyceryl Trinitrate OR Trinitrate, Glyceryl OR Nitroglycerin* OR diazoxide OR adenosine)

7. Diuretic

(diuretic OR diuretics OR diuretic* OR furosemide )

8. Aldosterone antagonist

(aldosteron antagonist OR aldosteron antagonists OR aldosterone antagonist OR aldosterone antagonists OR aldosterone antagonist* OR aldosteron antagonist* OR spironolactone)

9. (Other) antihypertensive agents

(antihypertensiva OR anti‐hypertensive OR anti hypertensive OR anti hypertensive drugs OR antihypertensive drugs OR antihypertensive agents OR Anti‐Hypertensive Agents OR Anti Hypertensive Agents OR Anti‐Hypertensive Drugs OR Anti Hypertensive Drugs OR Anti‐Hypertensives OR Anti Hypertensives OR Antihypertensive Drugs OR Antihypertensives OR antihypertensiv* OR antihypertensive drug* OR anti hypertensive drug* OR antihypertensive agent* OR anti hypertensive agent* OR clonidine)

10. Inotropic

(inotropics OR inotropic OR inotropic* OR dopamine OR dobutamine OR epinephrine OR norepinephrine)

11. Growth hormone

(growth hormone OR Pituitary Growth Hormone OR Somatotropin OR Recombinant Pituitary Growth Hormones OR Recombinant Somatotropin OR Recombinant Growth Hormone OR Recombinant Growth Hormones OR Recombinant Somatotropins OR growth hormon* OR Somatotropin* OR Pituitary Growth Hormon* OR Recombinant Pituitary Growth Hormon* OR Recombinant Somatotropin* OR Recombinant Growth Hormon*)

Total search strategy for medical interventions:

12. 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11

13. Anthracyclines

anthracyclines OR anthracyclin* OR anthracycline antibiotics OR 4‐demethoxydaunorubicin OR 4 demethoxydaunorubicin OR 4‐desmethoxydaunorubicin OR 4 desmethoxydaunorubicin OR IMI 30 OR IMI30 OR IMI‐30 OR idarubicin hydrochloride OR NSC 256439 OR NSC‐256439 OR NSC256439 OR idarubicin OR idarubic* OR 4'‐epiadriamycin OR 4' epiadriamycin OR 4'‐epidoxorubicin OR 4' epidoxorubicin OR 4'‐epi‐doxorubicin OR 4' epi doxorubicin OR 4'‐epi‐adriamycin OR 4' epi adriamycin OR 4'‐epi‐DXR OR 4' epi DXR OR epirubicin hydrochloride OR farmorubicin OR IMI‐28 OR IMI 28 OR IMI28 OR NSC 256942 OR NSC‐256942 OR NSC256942 OR epirubicin OR epirubic* OR adriablastine OR adriblastin OR adriablastin OR adriamycin OR DOX‐SL OR DOX SL OR doxorubicin hydrochloride OR doxorubic* OR adriamyc* OR dauno‐rubidomycine OR dauno rubidomycin OR rubidomycin OR rubomycin OR daunomycin OR cerubidine OR daunoblastin OR daunoblastine OR daunorubicin hydrochloride OR hydrochloride, daunorubicin OR daunorubic* OR rubidomyc* OR NSC‐82151 OR NSC 82151 OR NSC82151 OR daunoxome OR daunoxom* OR daunosom* OR doxil OR caelyx OR liposomal doxorubicin OR myocet OR doxorubicin OR daunorubicin

14. Childhood cancer

(leukemia OR leukemi* OR leukaemi* OR (childhood ALL) OR AML OR lymphoma OR lymphom* OR hodgkin* OR T‐cell OR B‐cell OR non‐hodgkin OR sarcoma OR sarcom* OR Ewing* OR osteosarcoma OR osteosarcom* OR wilms tumor OR wilms* OR nephroblastom* OR neuroblastoma OR neuroblastom* OR rhabdomyosarcoma OR rhabdomyosarcom* OR teratoma OR teratom* OR hepatoma OR hepatom* OR hepatoblastoma OR hepatoblastom* OR PNET OR medulloblastoma OR medulloblastom* OR PNET* OR neuroectodermal tumors, primitive OR retinoblastoma OR retinoblastom* OR meningioma OR meningiom* OR glioma OR gliom* OR pediatric oncology OR paediatric oncology OR childhood cancer OR childhood tumor OR childhood tumors OR cancer or neoplasms or tumor or cancers or neoplasm or tumors)

15. 12 AND 13 AND 14

All searches in Title, Abstract or Keywords in Cochrane Central Register of Controlled Trials (CENTRAL).