2015 Mar 05

New search has been performed

A search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Inborn Errors of Metabolism Trials Register identified two trials (Gramer 2009; Utz 2012). Both the trials were not eligible for inclusion.

The search of ClinicalTrials.gov identified one new ongoing trial which is potentially eligible for inclusion in future (NCT01977820).

Two of the trials identified in the previous search were completed (NCT01376908; NCT01114737). For both of the trials, according to the sponsors Merck KgaA (NCT01376908) and Biomarin Pharmaceutical Inc. (NCT01114737), full manuscripts will be published later in 2015. These two trials are listed in the 'Studies awaiting classification' section and their progress will be monitored for possible inclusion in future updates of the review. One trial identified in the previous 2012 search was terminated due to poor recruitment and is listed in the 'Excluded studies' section (Gropmann 2011).

The search of 'Current controlled trials' did not identify any trials.

2015 Mar 05

New citation required but conclusions have not changed

Minor changes were made throughout the review. One new, potentially relevant, ongoing trial is listed in the 'Ongoing studies' section of the review (NCT01977820). Two trials, currently listed in 'Studies awaiting classification' section are expected be completed and published later in 2015. These will be assessed for inclusion in a future update of the review (NCT01376908; NCT01114737).

2014 Mar 24

Amended

Contact details updated.