Scolaris Content Display Scolaris Content Display

Vitamin D supplementation for prevention of cancer in adults

This is not the most recent version

References

Additional references

Altman 2003

Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ 2003;326(7382):219. [MEDLINE: 12543843]

Anonymous 1997

Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board and Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy of Sciences. Washington, DC, 1997:250‐87.

Apperly 1941

Apperly FL. The relation of solar radiation to cancer mortality in North American. Cancer Research 1941;1:191‐5.

Autier 2007

Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta‐analysis of randomized controlled trials. Archives of Internal Medicine 2007;167(16):1730‐7. [MEDLINE: 17846391]

Begg 1994

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50(4):1088‐101. [MEDLINE: 7786990]

Bjelakovic 2008

Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Wetterslev J, Gluud C. Vitamin D supplementation for prevention of mortality. Cochrane Library2008.

Bradburn 2007

Bradburn MJ, Deeks JJ, Berlin JA, Russell Localio A. Much ado about nothing: a comparison of the performance of meta‐analytical methods with rare events. Statistics in Medicine 2007;26:53‐77.

Cohen 1960

Cohen J. A coefficient of agreement for nominal scales. Educational and Psychological Measurement 1960;20:37‐46.

Cranney 2007

Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, et al. Effectiveness and safety of vitamin D in relation to bone health Effectiveness and safety of vitamin D in relation to bone health. Evidence Report/Technology Assessment 2007;158:1‐235. [MEDLINE: 18088161]

Davis 2007

Davis CD, Dwyer JT. The "sunshine vitamin": benefits beyond bone?. Journal of the National Cancer Institute 2007;99(21):1563‐5. [MEDLINE: 17971523]

DeMets 1987

DeMets DL. Methods for combining randomized clinical trials: strengths and limitations. Statistics in Medicine 1987;6(3):341‐50. [MEDLINE: 3616287]

DerSimonian 1986

DerSimonian R, Laird N. Meta‐analysis in clinical trials. Controlled Clinical Trials 1986;7(3):177‐88. [MEDLINE: 3802833]

Egger 1997

Egger M, Davey SG, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. BMJ (Clinical Research Ed) 1997;315(7109):629‐34. [MEDLINE: 1997456606]

Flynn 2006

Flynn G, Chung I, Yu WD, Romano M, Modzelewski RA, Johnson CS, et al. Calcitriol (1,25‐dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor‐derived endothelial cells and induces apoptosis. Oncology 2006;70:447‐57.

Freedman 2007

Freedman DM, Looker AC, Chang SC, Graubard BI. Prospective study of serum vitamin D and cancer mortality in the United States. Jornal of the National Cancer Institute 2007;99(21):1594‐602. [MEDLINE: 17971526]

Friedrich 2007

Friedrich JO, Adhikari NK, Beyene J. Inclusion of zero total event trials in meta‐analyses maintains analytic consistency and incorporates all available data. BMC medical research methodology2007; Vol. 7, issue 5. [MEDLINE: 17244367]

Garland 1980

Garland CF, Garland FC. Do sunlight and vitamin D reduse the likelihood of colon cancer?. International Journal of Epidemiology 1980;9:227‐31. [MEDLINE: 7440046]

Garland 2006

Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, et al. The Role of Vitamin D in Cancer Prevention. American Journal of Public Health 2006;96(2):252‐61.

Garland 2007

Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: pooled analysis. The Journal of Steroid Biochemistry and Molecular Biology 2007;103(3‐5):708‐11. [MEDLINE: 17368188]

Giovannucci 2005

Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes & Control 2005;16(2):83‐95. [MEDLINE: 15868450]

Gluud 2006

Gluud LL. Bias in clinical intervention research. American Journal of Epidemiology 2006;163(6):493‐501. [MEDLINE: 16443796]

Gorham 2007

Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. American Journal of Preventive Medicine 2007;32(3):210‐6. [MEDLINE: 17296473]

Higgins 2002

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Statistics in Medicine 2002;21(11):1539‐58. [MEDLINE: 12111919]

Higgins 2003

Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta‐analysis. BMJ 2003;327:557‐60.

Higgins 2008

Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane‐handbook.org..

Holick 2004

Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. American Journal of Clinical Nutrition 2004;80(suppl):1678S– 88S.

Holick 2007

Holick MF. Vitamin D deficiency. New England Journal of Medicine 2007;357(3):266‐81. [MEDLINE: 17634462]

Horst 2005

Horst RL, Reinhardt TA, Satyanarayana Reddy G. Vitamin D metabolism. In: Feldman D, Wesley Pike J, Glorieux FH editor(s). Vitamin D. 2nd Edition. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier Academic Press, 2005:15‐36.

ICH‐GCP 1997

International Committee on Harmonization. Code of Federal Regulations & Guidelines Vol. 1, Philadelphia, US: Barnett International/PAREXEL, 1997.

Kjaergard 2001

Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta‐analyses. Annals of Internal Medicine 2001;135(11):982‐9. [MEDLINE: 11730399]

Lamberg‐Allardt 2006

Lamberg‐Allardt C. Vitamin D in foods and as supplements. Progress in Biophysics and Molecular Biology 2006;92:33‐8.

Lappe 2007

Lappe JM, Travers‐Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. American Journal of Clinical Nutrition 2007;85(6):1586‐91. [MEDLINE: 17556697]

Lau 2006

Lau J, Ioannidis JPA, Terrin N, Schmid CH, Olkin I. The case of the misleading funnel plot. BMJ 2006;333:597‐600.

Lips 2006

Lips P. Vitamin D physiology. Progress in Biophysics and Molecular Biology 2006;92(1):4‐8.

Marshall 2008

Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays 2008;30(2):173‐82. [MEDLINE: 18200565]

Mathers 2006

Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Medicine2006; Vol. 3, issue 11:e442. [MEDLINE: 17132052]

McAlister 2003

McAlister FA, Straus SE, Sackett DL, Altman DG. Analysis and reporting of factorial trials ‐ A systematic review. Journal of the American Medical Association 2003;289:2545‐53.

Michos 2008

Michos ED, Melamed ML. Vitamin D and cardiovascular disease risk. Current Opinion in Clinical Nutrition and Metabolic Care 2008;11(1):7‐12. [MEDLINE: 18090651]

Moher 1998

Moher D, Pham B, Jones A, Cook DJ, Jadad A, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta‐analysis. Lancet 1998;352(9128):609‐13. [MEDLINE: 9746022]

Moher 1999

Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta‐analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta‐analyses. Lancet 1999;354(9193):1896‐900.

Norman 2006

Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006;147(12):5542‐8. [MEDLINE: 16946007]

Schulz 1995

Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association 1995;273(5):408‐12. [7823387]

Schwartz 2007

Schwartz GG, Skinner HG. Vitamin D status and cancer: new insights. Current Opinion in Clinical Nutrition and Metabolic Care 2007;10(1):6‐11. [MEDLINE: 17143048]

Stolzenberg 2006

Stolzenberg‐Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, et al. A prospective nested case‐control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Research 2006;66(20):10213‐9. [MEDLINE: 17047087]

Sweeting 2004

Sweeting MJ, Sutton AJ, Lambert PC. What to add to nothing? Use and avoidance of continuity corrections in meta‐analyses of sparse data. Statistics in Medicine 2004;23:1351‐75.

van Leeuwen 2005

van Leeuwen JPTM, Pols HAP. Vitamin D: cancer and differentiation. In: Feldman D, Wesley Pike J, Glorieux FH editor(s). Vitamin D. 2nd Edition. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier Academic Press, 2005:1571‐97.

Wactawski‐Wende 2006

Wactawski‐Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O'Sullivan MJ. Calcium plus vitamin D supplementation and the risk of colorectal cancer. New England Journal of Medicine 2006;354(7):684‐96. [MEDLINE: 16481636]

Wesley Pike 2005

Wesley Pike J, Shevde Nk. The vitamin D receptor. In: Feldman D, Wesley Pike J, Glorieux FH editor(s). Vitamin D. 2nd Edition. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier Academic Press, 2005:167‐91.

Wetterslev 2008

Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta‐analysis. Journal of Clinical Epidemiology 2008;61(1):64‐75. [MEDLINE: 18083463]

Zittermann 2003

Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence. British Journal of Nutrition 2003;89(5):552‐72. [MEDLINE: 12720576]

Zittermann 2005

Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. British Journal of Nutrition 2005;94(4):483‐92. [MEDLINE: 16197570]

Zittermann 2006

Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Progress in Biophysics and Molecular Biology 2006;92(1):39‐48. [MEDLINE: 16600341]
Table 1. Study populations

study ID

intervention

[n] screened

[n] randomised

[n] safety

[n] ITT

[n] finishing study

comments

ID1

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID2

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID3

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID3

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID4

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID5

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID6

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID7

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID8

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ID9

Intervention 1 (I1)

Intervention 2 (I2)

Control 1 (C1)

Control 2 (C2)

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

I1:

I2:

C1:

C2:

Total:

ITT = intention‐to‐treat

Figures and Tables -
Table 1. Study populations