Quimioterapia con platino versus sin platino para el cáncer de pulmón de células pequeñas
Information
- DOI:
- https://doi.org/10.1002/14651858.CD006849.pub2Copy DOI
- Database:
-
- Cochrane Database of Systematic Reviews
- Version published:
-
- 08 October 2008see what's new
- Type:
-
- Intervention
- Stage:
-
- Review
- Cochrane Editorial Group:
-
Cochrane Lung Cancer Group
- Copyright:
-
- Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Cited by:
Authors
Contributions of authors
IUA ‐ Protocol writing, data extraction, analysis, review writing
JAEW ‐ Protocol writing, data extraction, analysis, review writing
RWB ‐ Supervisor, protocol writing, review writing
KMF ‐ Supervisor, review writing
Sources of support
Internal sources
-
No sources of support supplied
External sources
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The Australian Lung Foundation / Lung Cancer Consultative Group Cochrane Review Scholarship, Australia.
Declaraciones de interés
Ninguno conocido.
Agradecimientos
Se dan las gracias a Matthew Beech por su ayuda en la identificación de estudios para la inclusión.
Gracias a Wayne Chou y Melanie Sung por su ayuda en la extracción de los datos.
Se agradece a la Australian Lung Foundation por su apoyo a esta revisión.
Version history
Published | Title | Stage | Authors | Version |
2015 Aug 02 | Platinum versus non‐platinum chemotherapy regimens for small cell lung cancer | Review | Isuru U Amarasena, Saion Chatterjee, Julia AE Walters, Richard Wood‐Baker, Kwun M Fong | |
2008 Oct 08 | Platinum versus non‐platinum chemotherapy regimens for small cell lung cancer | Review | Isuru U Amarasena, Julia AE Walters, Richard Wood‐Baker, Kwun Fong | |
2007 Oct 17 | Platinum vs non‐platinum chemotherapy regimes for small cell lung cancer | Protocol | Isuru U Amarasena, Julia JAE Walters, Richard R Wood‐Baker, Kwun Fong | |
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Humans;
PICOs
Study ID | Number of Patients | Radiotherapy | |||
First Author | Year | Platinum group | Non‐platinum group | Total | |
Chahinian | 1989 | 105 | 103 | 208 | PCI |
Creech | 1982 | 21 | 19 | 40 | ‐ |
Eagan | 1981 | 31 | 31 | 62 | TRT |
Evans | 1987 | 145 | 144 | 289 | PCI, TRT |
Farris | 1993 | 56 | 57 | 113 | PCI, TRT |
Fukuoka | 1986 | 35 | 34 | 69 | TRT |
Fukuoka | 1991 | 97 | 97 | 194 | TRT |
Gatzemeier | 1994 | 171 | 173 | 344 | ‐ |
Goodman | 1990 | 194 | 194 | 388 | PCI, TRT |
Greco | 2005 | 60 | 60 | 120 | PCI |
Havemann | 1987 | 150 | 152 | 302 | PCI, TRT |
Jones | 1993 | 54 | 50 | 104 | PCI, TRT |
Kanitz | 1992 | 59 | 52 | 111 | ‐ |
Lyss | 2002 | 12 | 13 | 25 | PCI |
Postmus | 1992 | 60 | 63 | 123 | PCI |
Postmus | 1996 | 70 | 73 | 143 | ‐ |
Quoix | 2005 | 41 | 41 | 82 | ‐ |
Roth | 1992 | 148 | 146 | 294 | PCI |
Sculier | 1990 | 95 | 106 | 201 | PCI |
Sculier | 1993 | 107 | 108 | 215 | PCI, TRT |
Smith | 1991 | 47 | 48 | 95 | PCI |
Souhami | 1997 | 80 | 75 | 155 | ‐ |
Sundstrom | 2002 | 218 | 218 | 436 | PCI, TRT |
Urban | 1999a | 191 | 203 | 394 | PCI, TRT |
Urban | 1999b | 229 | 228 | 457 | PCI, TRT |
Veronesi | 1994 | 70 | 66 | 136 | PCI, TRT |
Wampler | 1991 | 85 | 85 | 170 | ‐ |
White | 2001 | 60 | 59 | 119 | PCI, TRT |
Wolf | 1987 | 73 | 68 | 141 | PCI, TRT |
Total: 29 | ‐ | 2764 | 2766 | 5530 | ‐ |
PCI ‐ Prophylactic Cranial Irradiation TRT ‐ Thoracic Radiotherapy |
Undifferentiated | LD‐SCLC | ED‐SCLC | |||
Creech | 1982 | Eagan | 1981 | Chahinian | 1989 |
Farris^ | 1993 | Fukuoka | 1986 | Fukuoka | 1986 |
Fukuoka^ | 1991 | Goodman | 1990 | Gatzemeier | 1994 |
Postmus | 1992 | Havemann | 1987 | Greco | 2005 |
Sculier | 1990 | Jones | 1993 | Havemann | 1987 |
Sculier | 1993 | Sundstrom | 2002 | Jones | 1993 |
Smith | 1991 | Urban* | 1999a | Kanitz | 1992 |
Souhami | 1997 | Wolf | 1987 | Lyss | 2002 |
Urban | 1999b | ‐ | ‐ | Postmus | 1996 |
Veronesi | 1994 | ‐ | ‐ | Quoix | 2005 |
White | 2001 | ‐ | ‐ | Roth | 1992 |
‐ | ‐ | ‐ | ‐ | Sundstrom | 2002 |
‐ | ‐ | ‐ | ‐ | Urban* | 1999a |
‐ | ‐ | ‐ | ‐ | Wampler | 1991 |
‐ | ‐ | ‐ | ‐ | Wolf | 1987 |
^Presented undifferentiated survival data; response data sorted by stage. |
Subgroup | % Survival | ||
6 months | 12 months | 24 months | |
Undifferentiated | 67.59% | 30.70% | 7.85% |
LD‐SCLC | 88.86% | 58.68% | 21.14% |
ED‐SCLC | 64.96% | 30.27% | 7.41% |
Outcome | All studies | Higher quality studies |
6‐month survival | NSSD | NSSD |
12‐month survival | NSSD | NSSD |
24‐month survival | NSSD | NSSD |
Overall response | NSSD | NSSD |
Complete response | P | P |
Toxic death | NSSD | NSSD |
Nausea and Vomiting | NP | NP |
Alopecia | NSSD | NP |
Infection | NSSD | NSSD |
Anaemia | NP | NP |
Leukopenia | NSSD | P |
Thrombocytopenia | NP | NSSD |
Granulocytopenia | NSSD | NSSD |
NSSD ‐ No statistically significant difference between treatment groups. P ‐ Statistically significant effect favouring platinum‐based regimens. NP ‐ Statistically significant effect favouring non‐platinum‐based regimens. |
Outcome | All studies | Only studies using radiotherapy |
6‐month survival | NSSD | NSSD |
12‐month survival | NSSD | NSSD |
24‐month survival | NSSD | NSSD |
Overall response | NSSD | NSSD |
Complete response | P | P |
Toxic death | NSSD | NSSD |
Nausea and Vomiting | NP | NP |
Alopecia | NSSD | NSSD |
Infection | NSSD | NSSD |
Anaemia | NP | NP |
Leukopenia | NSSD | NSSD |
Thrombocytopenia | NP | NP |
Granulocytopenia | NSSD | NSSD |
NSSD ‐ No statistically significant difference between treatment groups. P ‐ Statistically significant effect favouring platinum‐based regimens. NP ‐ Statistically significant effect favouring non‐platinum‐based regimens. |
Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
1 6‐month survival Show forest plot | 28 | 5490 | Risk Ratio (M‐H, Random, 95% CI) | 1.05 [1.00, 1.09] |
1.1 Undifferentiated | 10 | 1808 | Risk Ratio (M‐H, Random, 95% CI) | 1.02 [0.94, 1.10] |
1.2 Limited Disease | 8 | 1044 | Risk Ratio (M‐H, Random, 95% CI) | 1.00 [0.94, 1.07] |
1.3 Extensive Disease | 16 | 2638 | Risk Ratio (M‐H, Random, 95% CI) | 1.11 [1.03, 1.19] |
2 12‐month survival Show forest plot | 28 | 5490 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.96, 1.16] |
2.1 Undifferentiated | 10 | 1808 | Risk Ratio (M‐H, Random, 95% CI) | 1.00 [0.82, 1.22] |
2.2 Limited Disease | 8 | 1044 | Risk Ratio (M‐H, Random, 95% CI) | 1.14 [0.92, 1.41] |
2.3 Extensive Disease | 16 | 2638 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.93, 1.21] |
3 24‐month survival Show forest plot | 26 | 5119 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.84, 1.33] |
3.1 Undifferentiated | 10 | 1808 | Risk Ratio (M‐H, Random, 95% CI) | 0.97 [0.71, 1.33] |
3.2 Limited Disease | 8 | 1044 | Risk Ratio (M‐H, Random, 95% CI) | 1.11 [0.67, 1.82] |
3.3 Extensive Disease | 14 | 2267 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.68, 1.71] |
4 Overall response Show forest plot | 28 | 5104 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.98, 1.15] |
4.1 Undifferentiated | 10 | 1945 | Risk Ratio (M‐H, Random, 95% CI) | 1.03 [0.86, 1.23] |
4.2 Limited Disease | 8 | 809 | Risk Ratio (M‐H, Random, 95% CI) | 1.03 [0.94, 1.12] |
4.3 Extensive Disease | 16 | 2350 | Risk Ratio (M‐H, Random, 95% CI) | 1.09 [0.97, 1.23] |
5 Complete response Show forest plot | 27 | 5054 | Risk Ratio (M‐H, Random, 95% CI) | 1.33 [1.13, 1.56] |
5.1 Undifferentiated | 9 | 1895 | Risk Ratio (M‐H, Random, 95% CI) | 1.24 [0.84, 1.83] |
5.2 Limited Disease | 8 | 809 | Risk Ratio (M‐H, Random, 95% CI) | 1.19 [1.02, 1.40] |
5.3 Extensive Disease | 16 | 2350 | Risk Ratio (M‐H, Random, 95% CI) | 1.48 [1.18, 1.87] |
6 Toxic Death Show forest plot | 18 | 3433 | Risk Ratio (M‐H, Random, 95% CI) | 1.20 [0.82, 1.76] |
7 Nausea and Vomiting Show forest plot | 19 | 3418 | Risk Ratio (M‐H, Random, 95% CI) | 1.51 [1.20, 1.90] |
8 Alopecia Show forest plot | 7 | 1246 | Risk Ratio (M‐H, Random, 95% CI) | 1.11 [0.96, 1.27] |
9 Infection Show forest plot | 10 | 1643 | Risk Ratio (M‐H, Random, 95% CI) | 0.82 [0.55, 1.21] |
10 Anaemia Show forest plot | 9 | 1676 | Risk Ratio (M‐H, Random, 95% CI) | 1.60 [1.22, 2.08] |
11 Leukopenia Show forest plot | 15 | 2293 | Risk Ratio (M‐H, Random, 95% CI) | 0.93 [0.76, 1.13] |
12 Thrombocytopenia Show forest plot | 17 | 3013 | Risk Ratio (M‐H, Random, 95% CI) | 2.10 [1.54, 2.86] |
12.1 New Subgroup | 17 | 3013 | Risk Ratio (M‐H, Random, 95% CI) | 2.10 [1.54, 2.86] |
13 Granulocytopenia Show forest plot | 5 | 1229 | Risk Ratio (M‐H, Random, 95% CI) | 0.89 [0.79, 1.00] |