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Exercise programs for people with dementia

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Appendices

Appendix 1. Top‐up update searches: August 2012 and October 2013

Source

 

Search strategy ‐ date limits are for the August 2012 search (appropriate limits were applied to the October 2013 search)

Hits retrieved

1. ALOIS (www.medicine.ox.ac.uk/alois)

"physical activity" OR exercise OR cycling OR swim* OR gym* OR walk* OR danc* OR yoga OR "tai chi" (all dates)

August 2012: 225

October 2013: 8

2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (Ovid SP)

 

1. exp Dementia/

2. Delirium/

3. Wernicke Encephalopathy/

4. Delirium, Dementia, Amnestic, Cognitive Disorders/

5. dement*.mp.

6. alzheimer*.mp.

7. (lewy* adj2 bod*).mp.

8. deliri*.mp.

9. (chronic adj2 cerebrovascular).mp.

10. ("organic brain disease" or "organic brain syndrome").mp.

11. ("normal pressure hydrocephalus" and "shunt*").mp.

12. "benign senescent forgetfulness".mp.

13. (cerebr* adj2 deteriorat*).mp.

14. (cerebral* adj2 insufficient*).mp.

15. (pick* adj2 disease).mp.

16. (creutzfeldt or jcd or cjd).mp.

17. huntington*.mp.

18. binswanger*.mp.

19. korsako*.mp.

20. or/1‐19

21. exercis*.ti,ab.

22. physical activit*.ti,ab.

23. cycling.ti,ab.

24. swim*.ti,ab.

25. gym*.ti,ab.

26. (walk* or treadmill).ti,ab.

27. danc*.ti,ab.

28. yoga*.ti,ab.

29. "tai chi".ti,ab.

30. exp Exercise/ or Exercise Therapy/

31. or/21‐30

32. 20 and 31

33. randomized controlled trial.pt.

34. controlled clinical trial.pt.

35. randomi?ed.ab.

36. placebo.ab.

37. randomly.ab.

38. trial.ab.

39. groups.ab.

40. or/33‐39

41. (animals not (humans and animals)).sh.

42. 40 not 41

43. 32 and 42

44. (2011* or 2012*).ed.

45. 43 and 44

 

August 2012: 97

October 2013: 93

3. EMBASE

1980‐2012 August 10 (Ovid SP)

1. exp dementia/

2. Lewy body/

3. delirium/

4. Wernicke encephalopathy/

5. cognitive defect/

6. dement*.mp.

7. alzheimer*.mp.

8. (lewy* adj2 bod*).mp.

9. deliri*.mp.

10. (chronic adj2 cerebrovascular).mp.

11. ("organic brain disease" or "organic brain syndrome").mp.

12. "supranuclear palsy".mp.

13. ("normal pressure hydrocephalus" and "shunt*").mp.

14. "benign senescent forgetfulness".mp.

15. (cerebr* adj2 deteriorat*).mp.

16. (cerebral* adj2 insufficient*).mp.

17. (pick* adj2 disease).mp.

18. (creutzfeldt or jcd or cjd).mp.

19. huntington*.mp.

20. binswanger*.mp.

21. korsako*.mp.

22. CADASIL.mp.

23. or/1‐22

24. exercis*.ti,ab.

25. physical activit*.ti,ab.

26. cycling.ti,ab.

27. swim*.ti,ab.

28. gym*.ti,ab.

29. (walk* or treadmill).ti,ab.

30. danc*.ti,ab.

31. yoga*.ti,ab.

32. "tai chi".ti,ab.

33. exercise/ or stretching exercise/ or anaerobic exercise/ or exercise intensity/ or aerobic exercise/ or treadmill exercise/ or aquatic exercise/

34. or/24‐33

35. 23 and 34

36. randomized controlled trial/

37. controlled clinical trial/

38. randomi?ed.ab.

39. placebo.ab.

40. randomly.ab.

41. trial.ab.

42. groups.ab.

43. ("double‐blind*" or "single‐blind*").ti,ab.

44. or/36‐43

45. 35 and 44

46. (2011* or 2012*).em.

47. 45 and 46

 

August 2012: 307

October 2013: 519

4. PsycINFO

1806‐August week 1 2012 (Ovid SP)

1. exp Dementia/

2. exp Delirium/

3. exp Huntingtons Disease/

4. exp Kluver Bucy Syndrome/

5. exp Wernickes Syndrome/

6. exp Cognitive Impairment/

7. dement*.mp.

8. alzheimer*.mp.

9. (lewy* adj2 bod*).mp.

10. deliri*.mp.

11. (chronic adj2 cerebrovascular).mp.

12. ("organic brain disease" or "organic brain syndrome").mp.

13. "supranuclear palsy".mp.

14. ("normal pressure hydrocephalus" and "shunt*").mp.

15. "benign senescent forgetfulness".mp.

16. (cerebr* adj2 deteriorat*).mp.

17. (cerebral* adj2 insufficient*).mp.

18. (pick* adj2 disease).mp.

19. (creutzfeldt or jcd or cjd).mp.

20. huntington*.mp.

21. binswanger*.mp.

22. korsako*.mp.

23. ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp.

24. or/1‐23

25. exercis*.ti,ab.

26. physical activit*.ti,ab.

27. cycling.ti,ab.

28. swim*.ti,ab.

29. gym*.ti,ab.

30. (walk* or treadmill).ti,ab.

31. danc*.ti,ab.

32. yoga*.ti,ab.

33. "tai chi".ti,ab.

34. exp Exercise/ or exp Aerobic Exercise/

35. or/25‐34

36. 24 and 35

37. random*.ti,ab.

38. exp Clinical Trials/

39. RCT.ti,ab.

40. CCT.ti,ab.

41. (placebo or "control group").ab.

42. trial.ti,ab.

43. groups.ab.

44. "double‐blind*".ti,ab.

45. "single‐blind*".ti,ab.

46. or/37‐45

47. 36 and 46

48. (2011* or 2012*).up.

49. 47 and 48

 

August 2012: 97

October 2013: 118

5. CINAHL (EBSCOhost)

S1 (MH "Dementia+")  

S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders")

S3 (MH "Wernicke's Encephalopathy")  

S4 TX dement*  

S5 TX alzheimer* 

S6 TX lewy* N2 bod*  

S7 TX deliri* 

S8 TX chronic N2 cerebrovascular  

S9 TX "organic brain disease" or "organic brain syndrome"  

S10 TX "normal pressure hydrocephalus" and "shunt*"  

S11 TX "benign senescent forgetfulness" 

S12 TX cerebr* N2 deteriorat* 

S13 TX cerebral* N2 insufficient*  

S14 TX pick* N2 disease

S15 TX creutzfeldt or jcd or cjd  

S16 TX huntington* 

S17 TX binswanger*  

S18 TX korsako* 

S19 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18

S20 TX exercis*

S21 TX "physical activit*" 

S22 TX cycling 

S23 TX swim*

S24 TX gym*

S25 TX walk* OR treadmill 

S26 TX danc*

S27 TX yoga*

S28 TX "tai chi" 

S29 (MH "Exercise+") 

S30 S20 or S21 or S22 or S23 or S24 or S25 or S26 or S27 or S28 or S29

S31 S19 and S30 

S32 (MH "Clinical Trials") 

S33 TX trial 

S34 TX RCT OR CCT 

S35 TX placebo*

S36 TX "double‐blind*" OR "single‐blind*" 

S37 TX groups OR "control group" 

S38 S32 or S33 or S34 or S35 or S36 or S37 

S39 S31 and S38 

S40 EM 2011

S41 EM 2012

S42 S40 OR S41

S43 S42 AND S39

 

August 2012: 101

October 2013: 107

6. ISI Web of Knowledge [includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports]

Topic=(Dement* OR Alzheimer* OR "Lewy body" OR arteriosclerosis OR "Huntington* disease" OR "Kluver Bucy" OR "Pick disease" OR "Wernicke encephalopathy" OR "Korsakoff psychosis") AND Topic=(exercis* OR walk* OR swim* OR "physical activit*" OR aerobic* OR danc* OR "tai chi" OR yoga*) AND Topic=(randomly OR placebo OR groups OR trial OR RCT OR randomized OR randomised) AND Year Published=(2011‐2012)

Timespan=All Years.

Search language=English   Lemmatization=On  

 

August 2012: 389

October 2013: 404

7. LILACS (BIREME)

dementia OR alzheimer$ OR demenc$ OR AD OR demência [Words] and exercício OR exercis$ OR walk$ OR swim$ OR aerobic$ [Words] and randomly OR randomised OR randomized OR trial OR ensaio clínico [Words]

August 2012: 11

October 2013: 5

8. CENTRAL (Issue 4, Dec 2011)

#1 MeSH descriptor Dementia explode all trees

#2 MeSH descriptor Delirium, this term only

#3 MeSH descriptor Wernicke Encephalopathy, this term only

#4 MeSH descriptor Delirium, Dementia, Amnestic, Cognitive Disorders, this term only

#5 dement*

#6 alzheimer*

#7 "lewy* bod*"

#8 deliri*

#9 "chronic cerebrovascular"

#10 "organic brain disease" or "organic brain syndrome"

#11 "normal pressure hydrocephalus" and "shunt*"

#12 "benign senescent forgetfulness"

#13 "cerebr* deteriorat*"

#14 "cerebral* insufficient*"

#15 "pick* disease"

#16 creutzfeldt or jcd or cjd

#17 huntington*

#18 binswanger*

#19 korsako*

#20 (#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19)

#21 MeSH descriptor Exercise explode all trees

#22 exercis*

#23 "physical activit*"

#24 cycling

#25 swim*

#26 gym*

#27 walk* OR treadmill

#28 danc*

#29 yoga*

#30 "tai chi"

#31 aerobic*

#32 (#21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31)

#33 (#32 AND #20), from 2011 to 2012 [Trials]

August 2012: 40

October 2013: 123

9. Clinicaltrials.gov (www.clinicaltrials.gov)

Interventional Studies | dementia OR alzheimers OR AD OR alzheimer's OR alzheimer OR lewy OR FTLD OR FLD | exercise OR aerobic OR aerobics OR walking OR swimming OR cycling | Adult, Senior | received from 09/01/2011 to 08/13/2012

August 2012: 13

October 2013: 19

10. ICTRP Search Portal (http://apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register]

Interventional Studies | dementia OR alzheimers OR AD OR alzheimer's OR alzheimer OR lewy OR FTLD OR FLD | exercise OR aerobic OR aerobics OR walking OR swimming OR cycling | received from 01/09/2011 to 13/08/2012

August 2012: 50

October 2013: 1

TOTAL before de‐duplication

August 2012: 1330

October 2013: 1397

TOTAL after de‐duplication

August 2012: 87

October 2013: 41

Appendix 2. Update search: September 2011

Source

 

Search strategy

Hits retrieved

1. ALOIS (www.medicine.ox.ac.uk/alois)

Keyword search: "physical activity" OR exercise cycling OR swim* OR gym* OR walk* OR danc* OR yoga OR "tai chi" (all dates)

217

2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (Ovid SP)

1. exp Dementia/

2. Delirium/

3. Wernicke Encephalopathy/

4. Delirium, Dementia, Amnestic, Cognitive Disorders/

5. dement*.mp.

6. alzheimer*.mp.

7. (lewy* adj2 bod*).mp.

8. deliri*.mp.

9. (chronic adj2 cerebrovascular).mp.

10. ("organic brain disease" or "organic brain syndrome").mp.

11. ("normal pressure hydrocephalus" and "shunt*").mp.

12. "benign senescent forgetfulness".mp.

13. (cerebr* adj2 deteriorat*).mp.

14. (cerebral* adj2 insufficient*).mp.

15. (pick* adj2 disease).mp.

16. (creutzfeldt or jcd or cjd).mp.

17. huntington*.mp.

18. binswanger*.mp.

19. korsako*.mp.

20. or/1‐19

21. exercis*.ti,ab.

22. physical activit*.ti,ab.

23. cycling.ti,ab.

24. swim*.ti,ab.

25. gym*.ti,ab.

26. (walk* or treadmill).ti,ab.

27. danc*.ti,ab.

28. yoga*.ti,ab.

29. "tai chi".ti,ab.

30. exp Exercise/ or Exercise Therapy/

31. or/21‐30

32. 20 and 31

33. randomized controlled trial.pt.

34. controlled clinical trial.pt.

35. randomi?ed.ab.

36. placebo.ab.

37. randomly.ab.

38. trial.ab.

39. groups.ab.

40. or/33‐39

41. (animals not (humans and animals)).sh.

42. 40 not 41

43. 32 and 42

44. (2007* or 2008* or 2009* or 2010* or 2011*).ed.

45. 43 and 44

 

230

3. EMBASE

1980‐2011 week 35 (Ovid SP)

1. exp dementia/

2. Lewy body/

3. delirium/

4. Wernicke encephalopathy/

5. cognitive defect/

6. dement*.mp.

7. alzheimer*.mp.

8. (lewy* adj2 bod*).mp.

9. deliri*.mp.

10. (chronic adj2 cerebrovascular).mp.

11. ("organic brain disease" or "organic brain syndrome").mp.

12. "supranuclear palsy".mp.

13. ("normal pressure hydrocephalus" and "shunt*").mp.

14. "benign senescent forgetfulness".mp.

15. (cerebr* adj2 deteriorat*).mp.

16. (cerebral* adj2 insufficient*).mp.

17. (pick* adj2 disease).mp.

18. (creutzfeldt or jcd or cjd).mp.

19. huntington*.mp.

20. binswanger*.mp.

21. korsako*.mp.

22. CADASIL.mp.

23. or/1‐22

24. exercis*.ti,ab.

25. physical activit*.ti,ab.

26. cycling.ti,ab.

27. swim*.ti,ab.

28. gym*.ti,ab.

29. (walk* or treadmill).ti,ab.

30. danc*.ti,ab.

31. yoga*.ti,ab.

32. "tai chi".ti,ab.

33. exercise/ or stretching exercise/ or anaerobic exercise/ or exercise intensity/ or aerobic exercise/ or treadmill exercise/ or aquatic exercise/

34. or/24‐33

35. 23 and 34

36. randomized controlled trial/

37. controlled clinical trial/

38. randomi?ed.ab.

39. placebo.ab.

40. randomly.ab.

41. trial.ab.

42. groups.ab.

43. ("double‐blind*" or "single‐blind*").ti,ab.

44. or/36‐43

45. 35 and 44

46. (2007* or 2008* or 2009* or 2010* or 2011*).em.

47. 45 and 46

48. limit 47 to human

 

443

4. PsycINFO

1806‐August week 5 2011 (Ovid SP)

1. exp Dementia/

2. exp Delirium/

3. exp Huntingtons Disease/

4. exp Kluver Bucy Syndrome/

5. exp Wernickes Syndrome/

6. exp Cognitive Impairment/

7. dement*.mp.

8. alzheimer*.mp.

9. (lewy* adj2 bod*).mp.

10. deliri*.mp.

11. (chronic adj2 cerebrovascular).mp.

12. ("organic brain disease" or "organic brain syndrome").mp.

13. "supranuclear palsy".mp.

14. ("normal pressure hydrocephalus" and "shunt*").mp.

15. "benign senescent forgetfulness".mp.

16. (cerebr* adj2 deteriorat*).mp.

17. (cerebral* adj2 insufficient*).mp.

18. (pick* adj2 disease).mp.

19. (creutzfeldt or jcd or cjd).mp.

20. huntington*.mp.

21. binswanger*.mp.

22. korsako*.mp.

23. ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp.

24. or/1‐23

25. exercis*.ti,ab.

26. physical activit*.ti,ab.

27. cycling.ti,ab.

28. swim*.ti,ab.

29. gym*.ti,ab.

30. (walk* or treadmill).ti,ab.

31. danc*.ti,ab.

32. yoga*.ti,ab.

33. "tai chi".ti,ab.

34. exp Exercise/ or exp Aerobic Exercise/

35. or/25‐34

36. 24 and 35

37. random*.ti,ab.

38. exp Clinical Trials/

39. RCT.ti,ab.

40. CCT.ti,ab.

41. (placebo or "control group").ab.

42. trial.ti,ab.

43. groups.ab.

44. "double‐blind*".ti,ab.

45. "single‐blind*".ti,ab.

46. or/37‐45

47. 36 and 46

48. (2007* or 2008* or 2009* or 2010* or 2011*).up.

49. 47 and 48

 

214

5. CINAHL (EBSCOhost)

S1 (MH "Dementia+")  

S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders")

S3 (MH "Wernicke's Encephalopathy")  

S4 TX dement*  

S5 TX alzheimer* 

S6 TX lewy* N2 bod*  

S7 TX deliri* 

S8 TX chronic N2 cerebrovascular  

S9 TX "organic brain disease" or "organic brain syndrome"  

S10 TX "normal pressure hydrocephalus" and "shunt*"  

S11 TX "benign senescent forgetfulness" 

S12 TX cerebr* N2 deteriorat* 

S13 TX cerebral* N2 insufficient*  

S14 TX pick* N2 disease

S15 TX creutzfeldt or jcd or cjd  

S16 TX huntington* 

S17 TX binswanger*  

S18 TX korsako* 

S19 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18

S20 TX exercis*

S21 TX "physical activit*" 

S22 TX cycling 

S23 TX swim*

S24 TX gym*

S25 TX walk* OR treadmill 

S26 TX danc*

S27 TX yoga*

S28 TX "tai chi" 

S29 (MH "Exercise+") 

S30 S20 or S21 or S22 or S23 or S24 or S25 or S26 or S27 or S28 or S29

S31 S19 and S30 

S32 (MH "Clinical Trials") 

S33 TX trial 

S34 TX RCT OR CCT 

S35 TX placebo*

S36 TX "double‐blind*" OR "single‐blind*" 

S37 TX groups OR "control group" 

S38 S32 or S33 or S34 or S35 or S36 or S37 

S39 S31 and S38 

S40 EM 2007 

S41 EM 2008 

S42 EM 2009 

S43 EM 2010 

S44 EM 2011 

S45 S40 or S41 or S42 or S43 or S44

S46 S39 and S45 

 

264

6. ISI Web of Knowledge [includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports]

Topic=(Dement* OR Alzheimer* OR "Lewy body" OR arteriosclerosis OR "Huntington* disease" OR "Kluver Bucy" OR "Pick disease" OR "Wernicke encephalopathy" OR "Korsakoff psychosis") AND Topic=(exercis* OR walk* OR swim* OR "physical activit*" OR aerobic* OR danc* OR "tai chi" OR yoga*) AND Topic=(randomly OR placebo OR groups OR trial OR RCT OR randomized OR randomised) AND Year Published=(2007‐2011)

Timespan=2007‐2011.

Search language=English   Lemmatization=On

 

641

7. LILACS (BIREME)

dementia OR alzheimer$ OR demenc$ OR AD OR demência [Words] and exercício OR exercis$ OR walk$ OR swim$ OR aerobic$ [Words] and randomly OR randomised OR randomized OR trial OR ensaio clínico [Words]

9

8. CENTRAL (Issue 2, 2011)

#1 MeSH descriptor Dementia explode all trees

#2 MeSH descriptor Delirium, this term only

#3 MeSH descriptor Wernicke Encephalopathy, this term only

#4 MeSH descriptor Delirium, Dementia, Amnestic, Cognitive Disorders, this term only

#5 dement*

#6 alzheimer*

#7 "lewy* bod*"

#8 deliri*

#9 "chronic cerebrovascular"

#10 "organic brain disease" or "organic brain syndrome"

#11 "normal pressure hydrocephalus" and "shunt*"

#12 "benign senescent forgetfulness"

#13 "cerebr* deteriorat*"

#14 "cerebral* insufficient*"

#15 "pick* disease"

#16 creutzfeldt or jcd or cjd

#17 huntington*

#18 binswanger*

#19 korsako*

#20 (#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19)

#21 MeSH descriptor Exercise explode all trees

#22 exercis*

#23 "physical activit*"

#24 cycling

#25 swim*

#26 gym*

#27 walk* OR treadmill

#28 danc*

#29 yoga*

#30 "tai chi"

#31 aerobic*

#32 (#21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31)

#33 (#32 AND #20), from 2007 to 2011

189

9. Clinicaltrials.gov (www.clinicaltrials.gov)

Interventional Studies | dementia OR alzheimers OR AD OR alzheimer's OR alzheimer OR lewy OR FTLD OR FLD | exercise OR aerobic OR aerobics OR walking OR swimming OR cycling | Adult, Senior | received from 09/01/2007 to 09/05/2011

29

10. ICTRP Search Portal (http://apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register]

Interventional Studies | dementia OR alzheimers OR AD OR alzheimer's OR alzheimer OR lewy OR FTLD OR FLD | exercise OR aerobic OR aerobics OR walking OR swimming OR cycling | Adult, Senior | received from 01/09/2007 to 05/09/2011

95

TOTAL before de‐duplication

2331

TOTAL after de‐duplication and first‐assessment

277

Study flow diagram
Figures and Tables -
Figure 1

Study flow diagram

Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included trials
Figures and Tables -
Figure 2

Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included trials

Risk of bias summary: review authors' judgments about each risk of bias item for each included trial
Figures and Tables -
Figure 3

Risk of bias summary: review authors' judgments about each risk of bias item for each included trial

Forest plot of comparison 1: Physical activity vs usual care: cognition
Figures and Tables -
Figure 4

Forest plot of comparison 1: Physical activity vs usual care: cognition

Forest plot of comparison 2: Physical activity vs usual care: Activities of daily living (ADLs)
Figures and Tables -
Figure 5

Forest plot of comparison 2: Physical activity vs usual care: Activities of daily living (ADLs)

Forest plot of comparison 3: Physical activity vs usual care: depression
Figures and Tables -
Figure 6

Forest plot of comparison 3: Physical activity vs usual care: depression

Comparison 1 Exercise vs usual care: cognition, Outcome 1 Cognition.
Figures and Tables -
Analysis 1.1

Comparison 1 Exercise vs usual care: cognition, Outcome 1 Cognition.

Comparison 2 Exercise vs usual care: Activities of Daily Living (ADL), Outcome 1 Comparison of ADL.
Figures and Tables -
Analysis 2.1

Comparison 2 Exercise vs usual care: Activities of Daily Living (ADL), Outcome 1 Comparison of ADL.

Comparison 3 Exercise vs usual care: depression, Outcome 1 Depression.
Figures and Tables -
Analysis 3.1

Comparison 3 Exercise vs usual care: depression, Outcome 1 Depression.

Comparison 1. Exercise vs usual care: cognition

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cognition Show forest plot

8

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

1.1 Cognition: all trials

8

329

Std. Mean Difference (IV, Random, 95% CI)

0.55 [0.02, 1.09]

1.2 Cognition: excluded moderate‐severe dementia

7

308

Std. Mean Difference (IV, Random, 95% CI)

0.31 [‐0.11, 0.74]

Figures and Tables -
Comparison 1. Exercise vs usual care: cognition
Comparison 2. Exercise vs usual care: Activities of Daily Living (ADL)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Comparison of ADL Show forest plot

6

289

Std. Mean Difference (IV, Random, 95% CI)

0.68 [0.08, 1.27]

1.1 ADL: all trials

6

289

Std. Mean Difference (IV, Random, 95% CI)

0.68 [0.08, 1.27]

Figures and Tables -
Comparison 2. Exercise vs usual care: Activities of Daily Living (ADL)
Comparison 3. Exercise vs usual care: depression

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Depression Show forest plot

5

341

Std. Mean Difference (IV, Random, 95% CI)

0.14 [‐0.07, 0.36]

Figures and Tables -
Comparison 3. Exercise vs usual care: depression