Appendix 1. Search strategy

MEDLINE search strategy

#1 Insecticide organothiophosphate
#2 Organophosphorus compounds
#3 Phosphoamino acid
#4 Phosphorus compounds
#5 Cholinesterase inhibitors
#6 Cholinesterase reactivators
#7 (insecticide* or OP or organophos* or organothiophos* or pesticide*) in TI, AB
#8 #1 or #2 or #3 or #4 or #5 or #6 or #7
#9 explode "Poisoning‐" /
#10 explode "Overdose‐" /
#11 poison* or over?dos* or (attempt* next suicide*) in TI, AB
#12 #9 or #10 or #11
#13 #8 and #12
#14 explode \hemofiltration /
#15 explode \hemoperfusion /
#16 explode \ultrafiltration / a
#17 explode \plasmapheresis /
#18 Extracorporeal next (ultrafiltration or Circulation or purification) in TI, AB
#19 CAVH in TI, AB
#20 H?emofiltration or H?emosorption or H?emoperfusion or H?emodialysis or Plasmapheresis in TI, AB
#21 Continuous renal replacement therapy in TI, AB
#22 Continuous venovenous h?emofiltration in TI, AB
#23 Continuous blood purification in TI, AB
#24 Immunoadsorption in TI, AB
#25 slow low‐efficient daily dialysis in TI, AB
#26 #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25
#27 #13 and #26
#28 pharmacokinetic in TI,AB
#29 exp Pharmacokinetics/
#30 #28 or #29
#31 #30 or RCT search strategy*
#32 #27 and #31
*The RCT search strategy is based on an optimally sensitive MEDLINE search strategy for identifying randomised controlled trials in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2005). 

EMBASE search strategy

1. exp Organophosphate Insecticide/
2. exp Organophosphorus Compound/
3. exp Phosphorus Derivative/
4. exp Phosphoamino Acid/
5. exp Cholinesterase Inhibitor/
6. exp Cholinesterase Reactivator/
7. (insecticide$ or OP or organophos$ or organothiophos$ or pesticide$).ab,ti.
8. or/1‐7
9. exp intoxication/ or exp toxicity/
10. (poison$ or over‐dos$ or (attempt$ adj3 suicide$)).ab,ti.
11. 9 or 10
12. 8 and 11
13. exp hemofiltration/
14. exp hemoperfusion/
15. exp ultrafiltration/
16. exp blood filtration/
17. exp plasmapheresis/
18. (Extracorporeal adj3 (ultrafiltration or Circulation or purification)).ab,ti.
19. CAVH.ab,ti.
20. (Hemofiltration or Haemofiltration or Hemosorption or Haemosorption or Hemoperfusion or Haemoperfusion or Hemodialysis or Haemodialysis).ab,ti.
21. Continuous renal replacement therapy.ab,ti.
22. (Continuous adj1 venovenous adj1 (hemofiltration or haemofiltration)).ab,ti.
23. Continuous blood purification.ab,ti.
24. Immunoadsorption.ab,ti.
25. slow low‐efficient daily dialysis.ab,ti.
26. or/13‐25
27. 12 and 26
28. exp PHARMACOKINETICS/
29. Pharmacokinetics.ab,ti.
30. 28 or 29
31. RCT search strategy
32. 30 OR 31
33. 27 AND 33
*The RCT search strategy is based on an optimally sensitive MEDLINE search strategy for identifying randomised controlled trials in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2005) and has been adapted for use in EMBASE.

Current Awareness in Clinical Toxicology (CACT)

[organophos* AND (extracorporeal OR hemoperfus* OR haemoperfus* OR hemodia* or haemodia* or plasmapheresis OR 'renal replacement' OR hemofilt* OR haemofilt*)]

www.google.com

(organothiophosphate OR phosphoamino OR organophosphate OR organophosphorus) NEAR (overdose OR poisoning) NEAR (hemoperfusion OR hemodialysis OR hemosorption OR hemofiltration OR ultrafiltration OR plasmapheresis OR CAVH OR CVVH OR CRRT).The first 400 entries will be reviewed. 

Info Trac

[organophos* AND (extracorporeal OR hemoperfus* OR haemoperfus* OR hemodia* or haemodia* or plasmapheresis OR 'renal replacement' OR hemofilt* OR haemofilt*)]