Heparin‐bonded catheters for prolonging the patency of central venous catheters in children
Information
- DOI:
- https://doi.org/10.1002/14651858.CD005983.pub3Copy DOI
- Database:
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- Cochrane Database of Systematic Reviews
- Version published:
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- 25 February 2014see what's new
- Type:
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- Intervention
- Stage:
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- Review
- Cochrane Editorial Group:
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Cochrane Vascular Group
- Copyright:
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- Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Cited by:
Authors
Contributions of authors
PS Shah selected trials, assessed trial quality, extracted data, wrote and edited the final review.
N Shah selected trials, assessed trial quality, extracted data and edited the final review.
Sources of support
Internal sources
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Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada.
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Department of Hematology and Oncology, Clinical Fellowship Program, The Hospital for Sick Children, Toronto, Canada.
External sources
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Chief Scientist Office, Scottish Government Health Directorates, The Scottish Government, UK.
The PVD Group editorial base is supported by the Chief Scientist Office.
Declarations of interest
None known
Acknowledgements
We would like to thank Dr C Pierce for providing additional data on her group's study. We would also like to thank the Cochrane Consumer Network for providing a plain language summary and the Cochrane Peripheral Vascular Diseases Group for their assistance.
Version history
| Published | Title | Stage | Authors | Version |
| 2014 Feb 25 | Heparin‐bonded catheters for prolonging the patency of central venous catheters in children | Review | Prakeshkumar S Shah, Niketa Shah | |
| 2007 Oct 17 | Heparin‐bonded catheters for prolonging the patency of central venous catheters in children | Review | Prakeshkumar S Shah, Niketa Shah | |
| 2006 Apr 19 | Heparin‐bonded catheters for prolonging the patency of central venous catheters in children | Protocol | Prakeshkumar S Shah, Niketa Shah | |
Differences between protocol and review
None
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Adolescent; Child; Child, Preschool; Humans; Infant; Infant, Newborn;
PICOs
Study flow diagram for updated review.
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Forest plot of comparison: 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, outcome: 1.1 Catheter‐related thrombosis at any time during catheter stay.
Forest plot of comparison: 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, outcome: 1.8 Thrombocytopenia after catheter insertion.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 1 Catheter‐related thrombosis at any time during catheter stay.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 2 Catheter‐related thrombosis within one week of catheter insertion.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 3 Catheter‐related thrombosis after one week of insertion.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 4 Occlusion of catheter within one week of catheter insertion.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 5 Occlusion of catheter after one week of catheter insertion.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 6 Catheter‐related blood stream infection.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 7 Colonization of catheter with microbes.
Comparison 1 Heparin‐bonded catheter versus non‐heparin bonded catheters, Outcome 8 Thrombocytopenia after catheter insertion.
| Heparin‐bonded catheter compared with non‐heparin bonded catheter for central venous catheter in children | ||||||
| Participant or population: Children with central venous catheter Settings: Hospital Intervention: Heparin‐bonded central venous catheter Comparison: Non‐heparin bonded central venous catheter | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect | No of Participants | Quality of the evidence | Comments | |
| Assumed risk | Corresponding risk | |||||
| Non heparin‐bonded catheter | Heparin‐bonded catheter | |||||
| Days of catheter patency | median of 6 days | median of 7 days | 200 (1 study) | ⊕⊕⊝⊝ | Only one study reported this outcome | |
| Catheter‐related thrombosis at any time during catheter stay | 175 per 1000 | 59 per 1000 (2 to 1344) | RR 0.34 (0.01 to 7.68) | 287 (2 studies) | ⊕⊕⊕⊝ | |
| Occlusion of catheter within one week of catheter insertion | 78 per 1000 | 5 per 1000 (0 to 83) | RR 0.06 (0.00 to 1.07) | 200 (1 study) | ⊕⊕⊝⊝ | Only one study reported this outcome |
| Catheter‐related blood stream infection and CVC‐related colonization | 184 per 1000 | 11 per 1000 (2 to 75) | RR 0.06 (0.01 to 0.41) | 200 (1 study) | ⊕⊕⊝⊝ | Only one study reported this outcome |
| Side effects: Thrombocytopenia after catheter insertion | 133 per 1000 | 97 per 1000 (50 to 85) | RR 0.73 (0.38 to 1.39) | 287 (2 studies) | ⊕⊕⊝⊝ | No systematic evaluation of thrombocytopenia was conducted in either study |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). | ||||||
| GRADE Working Group grades of evidence | ||||||
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Catheter‐related thrombosis at any time during catheter stay Show forest plot | 2 | 287 | Risk Ratio (M‐H, Random, 95% CI) | 0.34 [0.01, 7.68] |
| 2 Catheter‐related thrombosis within one week of catheter insertion Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 3 Catheter‐related thrombosis after one week of insertion Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 4 Occlusion of catheter within one week of catheter insertion Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 5 Occlusion of catheter after one week of catheter insertion Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 6 Catheter‐related blood stream infection Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 7 Colonization of catheter with microbes Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 8 Thrombocytopenia after catheter insertion Show forest plot | 2 | 287 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.38, 1.39] |
