Scolaris Content Display Scolaris Content Display

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figures and Tables -
Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
Figures and Tables -
Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

Comparison 1 Systemic antibiotic (IV) compared with placebo, Outcome 1 Peristomal infection.
Figures and Tables -
Analysis 1.1

Comparison 1 Systemic antibiotic (IV) compared with placebo, Outcome 1 Peristomal infection.

Comparison 2 Systemic antibiotic (IV) compared with no intervention, Outcome 1 Peristomal infection.
Figures and Tables -
Analysis 2.1

Comparison 2 Systemic antibiotic (IV) compared with no intervention, Outcome 1 Peristomal infection.

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 1 Peristomal infection.
Figures and Tables -
Analysis 3.1

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 1 Peristomal infection.

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 2 Allocation concealment.
Figures and Tables -
Analysis 3.2

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 2 Allocation concealment.

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 3 Sponsorship.
Figures and Tables -
Analysis 3.3

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 3 Sponsorship.

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 1 Systemic antibiotic (IV) compared with systemic antibiotic (IV).
Figures and Tables -
Analysis 4.1

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 1 Systemic antibiotic (IV) compared with systemic antibiotic (IV).

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 2 Systemic antibiotic (PEG) compared with systemic antibiotic (IV).
Figures and Tables -
Analysis 4.2

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 2 Systemic antibiotic (PEG) compared with systemic antibiotic (IV).

Comparison 5 Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.
Figures and Tables -
Analysis 5.1

Comparison 5 Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.

Comparison 6 Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.
Figures and Tables -
Analysis 6.1

Comparison 6 Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.

Comparison 1. Systemic antibiotic (IV) compared with placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Peristomal infection Show forest plot

8

586

Odds Ratio (M‐H, Fixed, 95% CI)

0.34 [0.22, 0.53]

Figures and Tables -
Comparison 1. Systemic antibiotic (IV) compared with placebo
Comparison 2. Systemic antibiotic (IV) compared with no intervention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Peristomal infection Show forest plot

3

623

Odds Ratio (M‐H, Fixed, 95% CI)

0.30 [0.17, 0.53]

Figures and Tables -
Comparison 2. Systemic antibiotic (IV) compared with no intervention
Comparison 3. Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Peristomal infection Show forest plot

12

1271

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.26, 0.50]

2 Allocation concealment Show forest plot

12

1271

Odds Ratio (M‐H, Fixed, 95% CI)

0.47 [0.34, 0.65]

2.1 adequate allocation concealment

8

554

Odds Ratio (M‐H, Fixed, 95% CI)

0.58 [0.38, 0.88]

2.2 unclear/inadequate concealment

4

717

Odds Ratio (M‐H, Fixed, 95% CI)

0.34 [0.21, 0.58]

3 Sponsorship Show forest plot

12

1271

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.26, 0.50]

3.1 Trials with no sponsorship

10

962

Odds Ratio (M‐H, Fixed, 95% CI)

0.38 [0.25, 0.56]

3.2 Trials with sponsorship

2

309

Odds Ratio (M‐H, Fixed, 95% CI)

0.32 [0.18, 0.58]

Figures and Tables -
Comparison 3. Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic
Comparison 4. Systemic antibiotic compared with systemic antibiotic

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Systemic antibiotic (IV) compared with systemic antibiotic (IV) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 Peristomal infection

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Systemic antibiotic (PEG) compared with systemic antibiotic (IV) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 4. Systemic antibiotic compared with systemic antibiotic
Comparison 5. Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Peristomal infection Show forest plot

1

68

Odds Ratio (M‐H, Fixed, 95% CI)

15.78 [1.90, 130.86]

Figures and Tables -
Comparison 5. Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic
Comparison 6. Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Peristomal infection Show forest plot

1

62

Odds Ratio (M‐H, Fixed, 95% CI)

15.63 [1.84, 133.09]

Figures and Tables -
Comparison 6. Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic