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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 1 Mortality prior to discharge.
Figures and Tables -
Analysis 1.1

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 1 Mortality prior to discharge.

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 2 Pulmonary hypertensive crises.
Figures and Tables -
Analysis 1.2

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 2 Pulmonary hypertensive crises.

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 3 Difference in MPAP change score (SE).
Figures and Tables -
Analysis 1.3

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 3 Difference in MPAP change score (SE).

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 4 Difference in MAP change score (SE).
Figures and Tables -
Analysis 1.4

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 4 Difference in MAP change score (SE).

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 5 Difference in HR change score (SE).
Figures and Tables -
Analysis 1.5

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 5 Difference in HR change score (SE).

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 6 Difference in PaO2:FiO2 change score.
Figures and Tables -
Analysis 1.6

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 6 Difference in PaO2:FiO2 change score.

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 7 Maximum methaemoglobin level.
Figures and Tables -
Analysis 1.7

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 7 Maximum methaemoglobin level.

Table 1. Individual number of entries for outcome, "Difference in MPAP change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

17

20

Morris 2000

11

11

Figures and Tables -
Table 1. Individual number of entries for outcome, "Difference in MPAP change score (SE)"
Table 2. Individual number of entries for outcome,"Difference in MAP change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

18

20

Morris 2000

11

11

Figures and Tables -
Table 2. Individual number of entries for outcome,"Difference in MAP change score (SE)"
Table 3. Individual number of entries for outcome, "Difference in HR change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

12

17

Morris 2000

11

11

Figures and Tables -
Table 3. Individual number of entries for outcome, "Difference in HR change score (SE)"
Comparison 1. Inhaled nitric oxide versus placebo or conventional management

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality prior to discharge Show forest plot

2

162

Odds Ratio (M‐H, Fixed, 95% CI)

1.67 [0.38, 7.30]

2 Pulmonary hypertensive crises Show forest plot

1

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.8 [0.15, 4.18]

3 Difference in MPAP change score (SE) Show forest plot

3

Change in MPAP (Random, 95% CI)

‐2.94 [‐9.28, 3.40]

3.1 Conventional Management

2

Change in MPAP (Random, 95% CI)

‐1.14 [‐8.87, 6.59]

3.2 Placebo

1

Change in MPAP (Random, 95% CI)

‐9.15 [‐20.70, 2.40]

4 Difference in MAP change score (SE) Show forest plot

3

Change in MAP (Fixed, 95% CI)

‐3.55 [‐11.86, 4.76]

4.1 Conventional Mangement

2

Change in MAP (Fixed, 95% CI)

‐1.94 [‐11.23, 7.35]

4.2 Placebo

1

Change in MAP (Fixed, 95% CI)

‐10.0 [‐28.60, 8.60]

5 Difference in HR change score (SE) Show forest plot

3

Change in HR (Fixed, 95% CI)

0.02 [‐8.13, 8.18]

5.1 Conventional Management

2

Change in HR (Fixed, 95% CI)

‐0.37 [‐8.85, 8.10]

5.2 Placebo

1

Change in HR (Fixed, 95% CI)

5.0 [‐24.99, 34.99]

6 Difference in PaO2:FiO2 change score Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

17.18 [‐28.21, 62.57]

7 Maximum methaemoglobin level Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

0.30 [0.24, 0.36]

Figures and Tables -
Comparison 1. Inhaled nitric oxide versus placebo or conventional management