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Cochrane Database of Systematic Reviews

Interventions for cutaneous molluscum contagiosum

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Information

DOI:
https://doi.org/10.1002/14651858.CD004767.pub3Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 07 October 2009see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:
  1. Cochrane Skin Group

Copyright:
  1. Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Johannes C van der Wouden

    Correspondence to: Department of General Practice, Erasmus Medical Center, Rotterdam, Netherlands

    [email protected]

  • Renske van der Sande

    Department of General Practice, Erasmus Medical Center, Rotterdam, Netherlands

  • Lisette WA van Suijlekom‐Smit

    Department of Paediatrics, Paediatric Rheumatology, Erasmus MC ‐ Sophia Children's Hospital, Rotterdam, Netherlands

  • Marjolein Berger

    Department of General Practice, Erasmus Medical Center, Rotterdam, Netherlands

  • Christopher C Butler

    Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

  • Sander Koning

    Department of General Practice, Erasmus Medical Center, Rotterdam, Netherlands

Contributions of authors

Link with editorial base and co‐ordination of contributions from co‐authors: JCvdW
Protocol: JCvdW, SG, with contributions from all
Searches: SG, JM, JCvdW. Update 2009: RvdS, JCvdW
Screening abstracts: SG, JM, JCvdW. Update 2009: RvdS, JCvdW
Obtaining copies of trials: SG, JCvdW. Update 2009: RvdS, JCvdW
Assessing full papers for inclusion: SK, LvSS, MYB, JCvdW. Update 2009: RvdS, JCvdW
Extracting data from trials: CB, MYB, SK, JCvdW. Update 2009: RvdS, JCvdW
Assessing methodological quality: SG, SK, MB, JCvdW. Update 2009: RvdS, JCvdW
Data entry: JM, JCvdW. Update 2009: RvdS, JCvdW
Text of review: JM, JCvdW, with contributions from all. Update 2009: RvdS, JCvdW, with contributions from co‐authors.
Consumer feedback on synopsis: MJAT

Sources of support

Internal sources

  • Department of General Practice, Erasmus MC, Rotterdam, Netherlands.

External sources

  • No sources of support supplied

Declarations of interest

Anthony Ormerod who acted as a clinical content expert is also the author of one of the included trials. There has been no conflict of interest.

Acknowledgements

The authors thank Jack Menke, Sanjay Gajadin, and Marjolein Tasche for their assistance when writing the first version of our review. The authors would also like to thank Adrie Hollestein, Daan Muris, Kazutomo Ohkuma, Tony Ormerod, Jane Sterling, and Hywel Williams for drawing our attention to relevant studies.

Drs. Manchanda, Kazutomo Ohkuma, and Anthony Ormerod kindly provided additional information regarding their studies, and Kate Short and Mohammed Bazza generously sent us their full paper before it was submitted for publication. The editorial base provided help in tracing and translating papers. We also thank Himiko Luiken for translating the unique study on the natural history of molluscum contagiosum by Tsukasa Takemura and colleagues, and Taixiang Wu for interviewing Dr He on details of her study design. We thank Alireza Firooz for assessing the paper by Salmanpour and colleagues, and Susheera Chatpoedprai for providing additional information on their study.

The editorial base would like to thank the following people who were external referees for this review: Anthony Ormerod and Paula Beattie (content experts) and Jack Tweed (Consumer). They would also like to thank Philippa Middleton (Methods Editor) and Jo Leonardi‐Bee (Statistical Editor) for their help with restructuring the review and analysing the data.

We thank Finola Delamere, Philippa Middleton, Tina Leonard, Jo Leonardi‐Bee, Hywel Williams, Jack Gibson, Bob Dellavalle, Alan Arbuckle, Anthony Ormerod, Paula Beatty, and Jack Tweed for their comments on earlier drafts of the review.

For the update of this review the editorial base would like to thank the Key Editor Bob Dellavalle with Alan Arbuckle, Jack Gibson who acted as the statistical referee, Anthony Ormerod who was the clinical content referee, and Jack Tweed the consumer referee.

Version history

Published

Title

Stage

Authors

Version

2017 May 17

Interventions for cutaneous molluscum contagiosum

Review

Johannes C van der Wouden, Renske van der Sande, Emma J Kruithof, Annet Sollie, Lisette WA van Suijlekom‐Smit, Sander Koning

https://doi.org/10.1002/14651858.CD004767.pub4

2009 Oct 07

Interventions for cutaneous molluscum contagiosum

Review

Johannes C van der Wouden, Renske van der Sande, Lisette WA van Suijlekom‐Smit, Marjolein Berger, Christopher C Butler, Sander Koning

https://doi.org/10.1002/14651858.CD004767.pub3

2009 Jul 08

Interventions for cutaneous molluscum contagiosum

Review

Johannes C van der Wouden, Sander Koning, Lisette WA van Suijlekom‐Smit, Marjolein Berger, Christopher Butler, Jack Menke, Sanjay Gajadin, Marjolein JA Tasche

https://doi.org/10.1002/14651858.CD004767.pub2

2004 Apr 19

Interventions for molluscum contagiosum in children

Protocol

Johannes C van der Wouden, Sanjay Gajadin, Marjolein Y Berger, Christopher CC Butler, Sander Koning, Jack Menke, Marjolein JA Tasche, A van Suijlekom‐Smit LW, Lisette WA van Suijlekom‐Smit

https://doi.org/10.1002/14651858.CD004767

Differences between protocol and review

The title of the published protocol was inadvertently left as 'Interventions for molluscum contagiosum in children' although the decision had already been made not to restrict the review to children.

Under 'Secondary outcome measures' (b) and (g) were not initially specified in the protocol, but were added afterwards since improvement at the end of the study was frequently the most commonly reported outcome measure, and disease‐related quality of life was considered to be a relevant additional measure.

Under 'Selection of studies' if an RCT included a variety of skin diseases, including molluscum contagiosum, the number of molluscum participants needed to be at least five in the active treatment and placebo groups. This criterion was added after the protocol was approved when a study was found which included 10 molluscum participants with a 9:1 distribution over the two treatment groups (Caballero 1996). The criterion also applied to Manchanda 1997a.

Under 'Assessment of Risk of bias' Items (d), (e), and (f) were different from the original protocol or absent. They were added for the 2009 update, as recommended in the Handbook (Higgins 2008).

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.