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Cochrane Database of Systematic Reviews

First‐line tandem high‐dose chemotherapy and autologous stem cell transplantation versus single high‐dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies

Information

DOI:
https://doi.org/10.1002/14651858.CD004626.pub3Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 17 October 2012see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:

  1. Cochrane Haematology Group

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Frauke Naumann‐Winter

    Correspondence to: Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany

    [email protected]

    [email protected]

    Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

  • Alexander Greb

    Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

  • Peter Borchmann

    Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

  • Julia Bohlius

    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

  • Andreas Engert

    Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

    Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

  • Roland Schnell

    Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

    Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

Contributions of authors

NF: updating protocol (based on earlier version), searching, eligibility screening, data extraction and quality assessment, content input, interpretation of findings

AG: drafting of first version of the protocol, searching, eligibility screening

PB: interpretation of findings and providing a clinical perspective

JB: methodological expert

AE: providing a clinical perspective

RS: searching, eligibility screening, data checking and quality assessment, interpretation of findings, providing a clinical perspective

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • New Source of support, Not specified.

Declarations of interest

No interests to declare.

The views and opinions expressed in the systematic review are those of the individual authors and should not be attributed to the institutions where they are employed.

Acknowledgements

We would like to thank the Cochrane Haematological Malignancies Review Group Editorial Team for their support.

Version history

Published

Title

Stage

Authors

Version

2012 Oct 17

First‐line tandem high‐dose chemotherapy and autologous stem cell transplantation versus single high‐dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies

Review

Frauke Naumann‐Winter, Alexander Greb, Peter Borchmann, Julia Bohlius, Andreas Engert, Roland Schnell

https://doi.org/10.1002/14651858.CD004626.pub3

2008 Jan 23

First‐line double high‐dose chemotherapy and autologous stem cell transplantation versus single high‐dose chemotherapy and autologous stem cell transplantation in multiple myeloma

Protocol

Frauke Naumann, Roland Schnell, Christine Herbst, Corinne Brillant, Holger Schulz, Alexander Greb, Julia Bohlius, Benjamin Djulbegovic, Keith Wheatley, Andreas Engert

https://doi.org/10.1002/14651858.CD004626.pub2

2003 Oct 20

High‐dose chemotherapy and autologous stem cell transplantation for multiple myeloma

Protocol

Alexander Greb, Julia Bohlius, B Djulbegovic, K Wheatley, Thilo Kober, Andreas Engert, Guido Schwarzer, Michael Steurer

https://doi.org/10.1002/14651858.CD004626

Differences between protocol and review

While performing the review, we had to restrict our search to publications in English, French and German and had to exclude the database EMBASE due to budgetary restrictions.

Initially, it was planned to perform a statistical meta‐analysis for the included studies. In view of notable clinical heterogeneity and several methodological issues, the presented results are limited to a narrative systematic review. Furthermore, response and time‐to‐progression were not analysed. In addition to newly diagnosed patients, studies with previously treated patients were acceptable as long as the treatment was conventional and of limited duration (up to six months). Instead of limiting our systematic search to RCTs as planned in the protocol, we also searched for observational studies with contemporary control groups.

The outcome transplantation‐related mortality was only vaguely defined in the majority of trials. Instead of including only trials reporting transplantation mortality (as initially planned), we extracted results where all kind of definitions for early mortality were used.

Fewer authors contributed to the finalisation of the review compared to the protocol.

Notes

None