Oxygen therapy for cystic fibrosis
Information
- DOI:
- https://doi.org/10.1002/14651858.CD003884.pub4Copy DOI
- Database:
-
- Cochrane Database of Systematic Reviews
- Version published:
-
- 25 July 2013see what's new
- Type:
-
- Intervention
- Stage:
-
- Review
- Cochrane Editorial Group:
-
Cochrane Cystic Fibrosis and Genetic Disorders Group
- Copyright:
-
- Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Authors
Contributions of authors
The title for the protocol was conceived by George Mallory and the Cochrane Cystic Fibrosis and Genetic Disorders Group. Both David Vaughan and George Mallory designed and assisted in writing the protocol.
George Mallory and David Vaughan selected and assessed most of the studies and wrote the initial drafts. Jason Fullmer further assessed the studies, extracted data, created the figures and, with George Mallory, wrote the full review.
Heather Elphick has drafted the updated review and acts as guarantor of the review.
Declarations of interest
None known.
Acknowledgements
The authors would like to thank the staff of the Cochrane Cystic Fibrosis and Genetic Disorders Group for guidance and patience during the extended period during which this project materialized. They would also like to thank Dr David Vaughan for his contribution to the protocol and Dr Jason Fullmer for his contribution to the first published version of the review.
Version history
| Published | Title | Stage | Authors | Version |
| 2013 Jul 25 | Oxygen therapy for cystic fibrosis | Review | Heather E Elphick, George Mallory | |
| 2009 Jan 21 | Oxygen therapy for cystic fibrosis | Review | Heather E Elphick, George Mallory | |
| 2005 Oct 19 | Oxygen therapy for cystic fibrosis | Review | George Mallory, Jason J Fullmer, David J Vaughan | |
| 2002 Oct 21 | Oxygen therapy for cystic fibrosis | Protocol | George B Mallory, David J Vaughan | |
Differences between protocol and review
No subgroups analyses were planned in the original protocol and review. Post hoc plans for subgroup analyses have been added.
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Humans;
Comparison 1 Oxygen therapy versus control, Outcome 1 Survival.
Comparison 1 Oxygen therapy versus control, Outcome 2 Change in FEV1.
Comparison 1 Oxygen therapy versus control, Outcome 3 Change in FVC.
Comparison 1 Oxygen therapy versus control, Outcome 4 Change in gas exchange during exercise.
Comparison 1 Oxygen therapy versus control, Outcome 5 Change in gas exchange during sleep.
Comparison 1 Oxygen therapy versus control, Outcome 6 Change in PaO2.
Comparison 1 Oxygen therapy versus control, Outcome 7 Change in PaCO2.
Comparison 1 Oxygen therapy versus control, Outcome 8 Quality of life: regular attendance at school or work.
Comparison 1 Oxygen therapy versus control, Outcome 9 Sleep parameters.
Comparison 1 Oxygen therapy versus control, Outcome 10 Exercise parameters after submaximal exercise.
Comparison 1 Oxygen therapy versus control, Outcome 11 Exercise parameters during maximal exercise.
Comparison 1 Oxygen therapy versus control, Outcome 12 Nutritional status: change in % ideal body weight for height.
Comparison 1 Oxygen therapy versus control, Outcome 13 Changes in right heart function.
| Abbreviations | Definition |
| BiPAP | bileval positive airway pressure |
| BMI | body mass index |
| CO2 | carbon dioxide |
| COPD | chronic obstructive pulmonary disease |
| CPAP | continuous positive airway pressure |
| ETCO2 | end tidal carbon dioxide tension |
| FEV1 | forced expiratory volume in one second |
| FiO2 | fraction of inspired oxygen, or percent of oxygen in the inspired gas |
| FVC | forced vital capacity |
| kPa | kilopascal, a unit of air pressure |
| LVEF | left ventricular ejection fraction |
| mm Hg | millimeter of mercury, a unit of air pressure |
| MVV | maximal voluntary ventilation |
| NIPPV | non‐invasive positive pressure ventilation |
| NREM | non‐rapid eye movement |
| PaCO2 | arterial carbon dioxide tension |
| PaO2 | partial pressure of oxygen in the blood |
| PCO2 | partial pressure of carbon dioxide in the blood |
| PETCO2 | maximum partial pressure of carbon dioxide exhaled during a tidal breath, just prior to inspiration |
| REM | rapid eye movement |
| RVEF | right ventricular ejection fraction |
| SaO2 | saturation of haemoglobin with oxygen |
| SpO2 | pulse oximetry |
| TcCO2 | transcutaneous carbon dioxide |
| tPCO2 | transcutaneous partial pressure of carbon dioxide in the blood |
| VCO2 | carbon dioxide production |
| VE | mean total ventilation |
| VO2 | oxygen consumption |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Survival Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 1.1 Deaths at 36 months | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 2 Change in FEV1 Show forest plot | 1 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 2.1 At 6 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 2.2 At 12 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 3 Change in FVC Show forest plot | 1 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 3.1 At 6 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 3.2 At 12 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 4 Change in gas exchange during exercise Show forest plot | 5 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 4.1 Post exercise SaO2 (%) | 3 | 84 | Mean Difference (IV, Fixed, 95% CI) | 2.11 [1.54, 2.68] |
| 4.2 Post exercise PETCO2 (mm Hg) | 2 | 62 | Mean Difference (IV, Fixed, 95% CI) | 0.11 [‐2.14, 2.36] |
| 4.3 Change in SaO2 during maximal exercise (%) | 1 | 44 | Mean Difference (IV, Fixed, 95% CI) | 7.0 [2.61, 11.39] |
| 4.4 Change in PETCO2 during maximal exercise (mm Hg) | 2 | 112 | Mean Difference (IV, Fixed, 95% CI) | 3.71 [1.28, 6.14] |
| 4.5 Change in tPCO2 during maximal exercise (mm Hg) | 1 | 44 | Mean Difference (IV, Fixed, 95% CI) | 4.0 [1.23, 6.77] |
| 4.6 SaO2 during maximal exercise (%) | 3 | 108 | Mean Difference (IV, Fixed, 95% CI) | 2.01 [1.16, 2.85] |
| 5 Change in gas exchange during sleep Show forest plot | 3 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 5.1 SaO2 in REM sleep (%) | 2 | 34 | Mean Difference (IV, Fixed, 95% CI) | 7.54 [4.31, 10.77] |
| 5.2 tPCO2 in REM sleep (kPa) | 1 | 12 | Mean Difference (IV, Fixed, 95% CI) | 1.0 [0.15, 1.85] |
| 5.3 TcPCO2 in REM sleep (mm Hg) | 1 | 20 | Mean Difference (IV, Fixed, 95% CI) | 0.30 [‐6.69, 7.29] |
| 5.4 SaO2 in non‐REM sleep (%) | 1 | 12 | Mean Difference (IV, Fixed, 95% CI) | 6.0 [1.92, 10.08] |
| 5.5 tPCO2 in non‐REM sleep (kPa) | 1 | 12 | Mean Difference (IV, Fixed, 95% CI) | 0.70 [‐0.09, 1.49] |
| 5.6 TcPCO2 in non‐REM sleep (mm Hg) | 1 | 20 | Mean Difference (IV, Fixed, 95% CI) | ‐1.0 [‐6.51, 4.51] |
| 5.7 Maximum TcCO2 with total sleep (mm Hg) | 1 | 22 | Mean Difference (IV, Fixed, 95% CI) | 5.0 [‐2.07, 12.07] |
| 6 Change in PaO2 Show forest plot | 1 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 6.1 At 12 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 7 Change in PaCO2 Show forest plot | 1 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 7.1 At 12 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 8 Quality of life: regular attendance at school or work Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 8.1 At 6 months | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 8.2 At 12 months | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 9 Sleep parameters Show forest plot | 3 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 9.1 Percent of total sleep time in REM sleep (%) | 3 | 50 | Mean Difference (IV, Fixed, 95% CI) | ‐4.49 [‐6.04, ‐2.95] |
| 9.2 Percent of total sleep time in non‐REM sleep | 2 | 28 | Mean Difference (IV, Fixed, 95% CI) | 2.89 [‐0.41, 6.20] |
| 9.3 Sleep latency (minutes) | 1 | 12 | Mean Difference (IV, Fixed, 95% CI) | ‐6.0 [‐11.06, ‐0.94] |
| 9.4 Total sleep time (minutes) | 2 | 28 | Mean Difference (IV, Fixed, 95% CI) | 1.93 [‐30.38, 34.23] |
| 9.5 Arousal index | 1 | 12 | Mean Difference (IV, Fixed, 95% CI) | ‐2.10 [‐4.28, 0.08] |
| 10 Exercise parameters after submaximal exercise Show forest plot | 3 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 10.1 Exercise duration (s) | 1 | 16 | Mean Difference (IV, Fixed, 95% CI) | 163.0 [‐66.91, 392.91] |
| 10.2 Oxygen consumption (ml/kg/min) | 2 | 62 | Mean Difference (IV, Fixed, 95% CI) | ‐0.43 [‐2.06, 1.20] |
| 10.3 CO2 production (l/min) | 3 | 84 | Mean Difference (IV, Fixed, 95% CI) | ‐0.01 [‐0.11, 0.09] |
| 10.4 Minute ventilation (l/min) | 3 | 84 | Mean Difference (IV, Fixed, 95% CI) | ‐0.92 [‐3.36, 1.53] |
| 10.5 Heart rate (beats / min) | 3 | 84 | Mean Difference (IV, Fixed, 95% CI) | ‐3.96 [‐8.84, 0.92] |
| 11 Exercise parameters during maximal exercise Show forest plot | 4 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 11.1 Exercise duration (min) | 2 | 72 | Mean Difference (IV, Fixed, 95% CI) | 1.03 [0.11, 1.95] |
| 11.2 Ventilatory equivalent (VE/VO2) | 3 | 118 | Mean Difference (IV, Fixed, 95% CI) | ‐3.86 [‐6.82, ‐0.91] |
| 11.3 Maximum heart rate (beats / min) | 4 | 152 | Mean Difference (IV, Fixed, 95% CI) | ‐1.35 [‐6.05, 3.35] |
| 11.4 Maximum oxygen consumption (ml/kg/min) | 3 | 118 | Mean Difference (IV, Fixed, 95% CI) | 0.92 [‐2.02, 3.87] |
| 11.5 Minute ventilation (l/min) | 4 | 152 | Mean Difference (IV, Fixed, 95% CI) | ‐1.17 [‐7.06, 4.73] |
| 11.6 Ventilatory reserve utilisation (VE/MVV) | 2 | 74 | Mean Difference (IV, Fixed, 95% CI) | ‐0.05 [‐0.15, 0.05] |
| 12 Nutritional status: change in % ideal body weight for height Show forest plot | 1 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 12.1 At 6 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 12.2 At 12 months | 1 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 13 Changes in right heart function Show forest plot | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
| 13.1 Clinical signs of cor pulmonale | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 13.2 Abnormal rIght ventricular ejection fraction at rest | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
| 13.3 Abnormal right ejection fraction with exercise | 1 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] | |
