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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.1 QoL ‐ Change in CRQ (Fatigue).
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Figure 1

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.1 QoL ‐ Change in CRQ (Fatigue).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.2 QoL ‐ Change in CRQ (Emotional function).
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Figure 2

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.2 QoL ‐ Change in CRQ (Emotional function).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.3 QoL ‐ Change in CRQ (Mastery).
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Figure 3

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.3 QoL ‐ Change in CRQ (Mastery).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.4 QoL ‐ Change in CRQ (Dyspnea).
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Figure 4

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.4 QoL ‐ Change in CRQ (Dyspnea).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.5 QoL ‐ Change in SGRQ (Total).
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Figure 5

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.5 QoL ‐ Change in SGRQ (Total).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.6 QoL ‐ Change in SGRQ (Symptoms).
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Figure 6

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.6 QoL ‐ Change in SGRQ (Symptoms).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.7 QoL ‐ Change in SGRQ (Impacts).
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Figure 7

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.7 QoL ‐ Change in SGRQ (Impacts).

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Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.8 QoL ‐ Change in SGRQ (Activity).
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Figure 8

Forest plot of comparison: 1 Rehabilitation versus usual care, outcome: 1.8 QoL ‐ Change in SGRQ (Activity).

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Comparison 1 Rehabilitation versus usual care, Outcome 1 QoL ‐ Change in CRQ (Fatigue).
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Analysis 1.1

Comparison 1 Rehabilitation versus usual care, Outcome 1 QoL ‐ Change in CRQ (Fatigue).

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Comparison 1 Rehabilitation versus usual care, Outcome 2 QoL ‐ Change in CRQ (Emotional function).
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Analysis 1.2

Comparison 1 Rehabilitation versus usual care, Outcome 2 QoL ‐ Change in CRQ (Emotional function).

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Comparison 1 Rehabilitation versus usual care, Outcome 3 QoL ‐ Change in CRQ (Mastery).
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Analysis 1.3

Comparison 1 Rehabilitation versus usual care, Outcome 3 QoL ‐ Change in CRQ (Mastery).

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Comparison 1 Rehabilitation versus usual care, Outcome 4 QoL ‐ Change in CRQ (Dyspnea).
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Analysis 1.4

Comparison 1 Rehabilitation versus usual care, Outcome 4 QoL ‐ Change in CRQ (Dyspnea).

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Comparison 1 Rehabilitation versus usual care, Outcome 5 QoL ‐ Change in SGRQ (Total).
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Analysis 1.5

Comparison 1 Rehabilitation versus usual care, Outcome 5 QoL ‐ Change in SGRQ (Total).

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Comparison 1 Rehabilitation versus usual care, Outcome 6 QoL ‐ Change in SGRQ (Symptoms).
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Analysis 1.6

Comparison 1 Rehabilitation versus usual care, Outcome 6 QoL ‐ Change in SGRQ (Symptoms).

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Comparison 1 Rehabilitation versus usual care, Outcome 7 QoL ‐ Change in SGRQ (Impacts).
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Analysis 1.7

Comparison 1 Rehabilitation versus usual care, Outcome 7 QoL ‐ Change in SGRQ (Impacts).

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Comparison 1 Rehabilitation versus usual care, Outcome 8 QoL ‐ Change in SGRQ (Activity).
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Analysis 1.8

Comparison 1 Rehabilitation versus usual care, Outcome 8 QoL ‐ Change in SGRQ (Activity).

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Comparison 1 Rehabilitation versus usual care, Outcome 10 Functional exercise capacity.
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Analysis 1.10

Comparison 1 Rehabilitation versus usual care, Outcome 10 Functional exercise capacity.

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Comparison 1 Rehabilitation versus usual care, Outcome 11 Maximal exercise capacity.
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Analysis 1.11

Comparison 1 Rehabilitation versus usual care, Outcome 11 Maximal exercise capacity.

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Comparison 2 Sensitivity analysis of outcome by concealment of allocation and blinding of outcome assessment, Outcome 1 Maximal exercise capacity.
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Analysis 2.1

Comparison 2 Sensitivity analysis of outcome by concealment of allocation and blinding of outcome assessment, Outcome 1 Maximal exercise capacity.

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Comparison 1. Rehabilitation versus usual care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 QoL ‐ Change in CRQ (Fatigue) Show forest plot

11

618

Mean Difference (IV, Random, 95% CI)

0.92 [0.71, 1.13]

2 QoL ‐ Change in CRQ (Emotional function) Show forest plot

11

618

Mean Difference (IV, Random, 95% CI)

0.76 [0.52, 1.00]

3 QoL ‐ Change in CRQ (Mastery) Show forest plot

11

618

Mean Difference (IV, Random, 95% CI)

0.97 [0.74, 1.20]

4 QoL ‐ Change in CRQ (Dyspnea) Show forest plot

11

610

Mean Difference (IV, Random, 95% CI)

1.06 [0.85, 1.26]

5 QoL ‐ Change in SGRQ (Total) Show forest plot

6

384

Mean Difference (IV, Random, 95% CI)

‐6.11 [‐8.98, ‐3.24]

6 QoL ‐ Change in SGRQ (Symptoms) Show forest plot

6

384

Mean Difference (IV, Random, 95% CI)

‐4.68 [‐9.61, 0.25]

7 QoL ‐ Change in SGRQ (Impacts) Show forest plot

6

384

Mean Difference (IV, Random, 95% CI)

‐6.27 [‐10.08, ‐2.47]

8 QoL ‐ Change in SGRQ (Activity) Show forest plot

6

384

Mean Difference (IV, Random, 95% CI)

‐4.78 [‐7.83, ‐1.72]

10 Functional exercise capacity Show forest plot

16

669

Mean Difference (IV, Random, 95% CI)

48.46 [31.64, 65.28]

11 Maximal exercise capacity Show forest plot

13

511

Mean Difference (IV, Random, 95% CI)

8.43 [3.45, 13.41]
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Comparison 1. Rehabilitation versus usual care
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Comparison 2. Sensitivity analysis of outcome by concealment of allocation and blinding of outcome assessment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Maximal exercise capacity Show forest plot

7

335

Mean Difference (IV, Random, 95% CI)

5.89 [‐0.18, 11.96]
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Comparison 2. Sensitivity analysis of outcome by concealment of allocation and blinding of outcome assessment
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