Scolaris Content Display Scolaris Content Display

Comparison 1 Ibuprofen vs. indomethacin, Outcome 1 Failure to close a PDA (after single or three doses).
Figures and Tables -
Analysis 1.1

Comparison 1 Ibuprofen vs. indomethacin, Outcome 1 Failure to close a PDA (after single or three doses).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 2 All cause mortality.
Figures and Tables -
Analysis 1.2

Comparison 1 Ibuprofen vs. indomethacin, Outcome 2 All cause mortality.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 3 Neonatal mortality (during first 28/30 days of life).
Figures and Tables -
Analysis 1.3

Comparison 1 Ibuprofen vs. indomethacin, Outcome 3 Neonatal mortality (during first 28/30 days of life).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 5 Reopening of the ductus arteriosus.
Figures and Tables -
Analysis 1.5

Comparison 1 Ibuprofen vs. indomethacin, Outcome 5 Reopening of the ductus arteriosus.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 6 Need for surgical closure of the PDA.
Figures and Tables -
Analysis 1.6

Comparison 1 Ibuprofen vs. indomethacin, Outcome 6 Need for surgical closure of the PDA.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 8 Duration of ventilator support.
Figures and Tables -
Analysis 1.8

Comparison 1 Ibuprofen vs. indomethacin, Outcome 8 Duration of ventilator support.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 9 Intraventricular haemorrhage (Grade I‐IV).
Figures and Tables -
Analysis 1.9

Comparison 1 Ibuprofen vs. indomethacin, Outcome 9 Intraventricular haemorrhage (Grade I‐IV).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 10 Intraventricular haemorrhage (III‐IV).
Figures and Tables -
Analysis 1.10

Comparison 1 Ibuprofen vs. indomethacin, Outcome 10 Intraventricular haemorrhage (III‐IV).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 11 Periventricular leucomalacia (cystic).
Figures and Tables -
Analysis 1.11

Comparison 1 Ibuprofen vs. indomethacin, Outcome 11 Periventricular leucomalacia (cystic).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 12 Necrotizing enterocolitis (any stage).
Figures and Tables -
Analysis 1.12

Comparison 1 Ibuprofen vs. indomethacin, Outcome 12 Necrotizing enterocolitis (any stage).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 13 Decreased urine output (<1 cc/kg/hr).
Figures and Tables -
Analysis 1.13

Comparison 1 Ibuprofen vs. indomethacin, Outcome 13 Decreased urine output (<1 cc/kg/hr).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 14 Time to full enteral feeds.
Figures and Tables -
Analysis 1.14

Comparison 1 Ibuprofen vs. indomethacin, Outcome 14 Time to full enteral feeds.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 15 Retinopathy of prematurity.
Figures and Tables -
Analysis 1.15

Comparison 1 Ibuprofen vs. indomethacin, Outcome 15 Retinopathy of prematurity.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 17 Chronic lung disease (at 28 days).
Figures and Tables -
Analysis 1.17

Comparison 1 Ibuprofen vs. indomethacin, Outcome 17 Chronic lung disease (at 28 days).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 18 Chronic lung disease (at 36 weeks corrected postmenstrual age).
Figures and Tables -
Analysis 1.18

Comparison 1 Ibuprofen vs. indomethacin, Outcome 18 Chronic lung disease (at 36 weeks corrected postmenstrual age).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 19 Sepsis.
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Analysis 1.19

Comparison 1 Ibuprofen vs. indomethacin, Outcome 19 Sepsis.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 20 Duration of hospitalization.
Figures and Tables -
Analysis 1.20

Comparison 1 Ibuprofen vs. indomethacin, Outcome 20 Duration of hospitalization.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 21 Days on supplementary oxygen.
Figures and Tables -
Analysis 1.21

Comparison 1 Ibuprofen vs. indomethacin, Outcome 21 Days on supplementary oxygen.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 22 Gastrointestinal bleed.
Figures and Tables -
Analysis 1.22

Comparison 1 Ibuprofen vs. indomethacin, Outcome 22 Gastrointestinal bleed.

Comparison 1 Ibuprofen vs. indomethacin, Outcome 23 Failure to close a PDA (after 3 doses).
Figures and Tables -
Analysis 1.23

Comparison 1 Ibuprofen vs. indomethacin, Outcome 23 Failure to close a PDA (after 3 doses).

Comparison 1 Ibuprofen vs. indomethacin, Outcome 24 Failure to close a PDA (after 3 doses, abstracts excluded).
Figures and Tables -
Analysis 1.24

Comparison 1 Ibuprofen vs. indomethacin, Outcome 24 Failure to close a PDA (after 3 doses, abstracts excluded).

Comparison 1. Ibuprofen vs. indomethacin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Failure to close a PDA (after single or three doses) Show forest plot

11

620

Risk Ratio (M‐H, Fixed, 95% CI)

0.96 [0.74, 1.25]

2 All cause mortality Show forest plot

4

301

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.39, 1.57]

3 Neonatal mortality (during first 28/30 days of life) Show forest plot

1

148

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [0.41, 3.31]

4 Infant mortality (death during the first year of life)

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Reopening of the ductus arteriosus Show forest plot

3

120

Risk Ratio (M‐H, Fixed, 95% CI)

1.32 [0.47, 3.74]

6 Need for surgical closure of the PDA Show forest plot

7

530

Risk Ratio (M‐H, Fixed, 95% CI)

0.93 [0.58, 1.49]

7 Need for treatment with indomethacin to close the PDA

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Duration of ventilator support Show forest plot

3

278

Mean Difference (IV, Fixed, 95% CI)

‐1.05 [‐4.17, 2.06]

9 Intraventricular haemorrhage (Grade I‐IV) Show forest plot

3

126

Risk Ratio (M‐H, Fixed, 95% CI)

0.76 [0.30, 1.90]

10 Intraventricular haemorrhage (III‐IV) Show forest plot

2

238

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.46, 2.50]

11 Periventricular leucomalacia (cystic) Show forest plot

3

386

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.53, 2.47]

12 Necrotizing enterocolitis (any stage) Show forest plot

5

456

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.35, 1.07]

13 Decreased urine output (<1 cc/kg/hr) Show forest plot

2

323

Risk Ratio (M‐H, Fixed, 95% CI)

0.22 [0.09, 0.51]

14 Time to full enteral feeds Show forest plot

3

386

Mean Difference (IV, Fixed, 95% CI)

1.14 [‐1.50, 3.77]

15 Retinopathy of prematurity Show forest plot

2

103

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.39, 1.32]

16 Pneumothorax

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

17 Chronic lung disease (at 28 days) Show forest plot

2

188

Risk Ratio (M‐H, Fixed, 95% CI)

1.37 [1.01, 1.86]

18 Chronic lung disease (at 36 weeks corrected postmenstrual age) Show forest plot

2

238

Risk Ratio (M‐H, Fixed, 95% CI)

1.28 [0.77, 2.10]

19 Sepsis Show forest plot

4

386

Risk Ratio (M‐H, Fixed, 95% CI)

1.46 [0.72, 2.96]

20 Duration of hospitalization Show forest plot

2

238

Mean Difference (IV, Fixed, 95% CI)

‐3.52 [‐9.87, 2.83]

21 Days on supplementary oxygen Show forest plot

2

215

Mean Difference (IV, Fixed, 95% CI)

6.84 [‐3.12, 16.81]

22 Gastrointestinal bleed Show forest plot

2

86

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.14, 3.25]

23 Failure to close a PDA (after 3 doses) Show forest plot

10

587

Risk Ratio (M‐H, Fixed, 95% CI)

0.95 [0.72, 1.25]

24 Failure to close a PDA (after 3 doses, abstracts excluded) Show forest plot

7

498

Risk Ratio (M‐H, Fixed, 95% CI)

0.89 [0.66, 1.19]

Figures and Tables -
Comparison 1. Ibuprofen vs. indomethacin