Tratamiento con cisapride para el reflujo gastroesofágico en niños
Information
- DOI:
- https://doi.org/10.1002/14651858.CD002300Copy DOI
- Database:
-
- Cochrane Database of Systematic Reviews
- Version published:
-
- 20 October 2003see what's new
- Type:
-
- Intervention
- Stage:
-
- Review
- Cochrane Editorial Group:
-
Cochrane Gut Group
- Copyright:
-
- Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Cited by:
Authors
Contributions of authors
All reviewers contributed to the design of the study, the development of the protocol, to the writing of the updated version of this review.
Sources of support
Internal sources
-
Systematic Reviews Training Unit, UK.
External sources
-
No sources of support supplied
Declaraciones de interés
Ninguno conocido.
Agradecimientos
Agradecemos al Profesor Geoffrey P Davidson por proporcionar información adicional de un ensayo; al Dr. Billy Bourke, el Profesor B Drumm y el Dr. Jaqui Dalby‐Payne por sus comentarios sobre el primer borrador de la revisión original, a Susan Orenstein por sus comentarios sobre una versión posterior y a Melissa Harden por su ayuda en la búsqueda de ensayos no publicados de la compañía farmacéutica Janssen.
Version history
| Published | Title | Stage | Authors | Version |
| 2010 Apr 14 | Cisapride treatment for gastro‐oesophageal reflux in children | Review | Suzanna MacLennan, Cristina Augood, Lucinda Cash‐Gibson, Stuart Logan, Ruth E Gilbert | |
| 2003 Oct 20 | Cisapride treatment for gastro‐oesophageal reflux in children | Review | Cristina Augood, Suzanna MacLennan, Ruth E Gilbert, Stuart Logan | |
Notes
All authors contributed to the overall design of the study and the development of the protocol for study inclusion and data extraction.
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Humans; Infant; Infant, Newborn;
Comparison 1 Main analysis for Cisapride vs placebo, Outcome 1 'Worse, same or slight improvement' vs 'moderate or excellent improvement'.
Comparison 1 Main analysis for Cisapride vs placebo, Outcome 2 Reflux index.
Comparison 1 Main analysis for Cisapride vs placebo, Outcome 3 Adverse events.
Comparison 2 Main analysis for Cisapride vs Gaviscon/Carobel, Outcome 1 'Worse, same or slight improvement' vs 'moderate or excellent improvement'.
Comparison 3 Sensitivity analyses for Cisapride vs placebo, Outcome 1 Best case scenario.
Comparison 3 Sensitivity analyses for Cisapride vs placebo, Outcome 2 Worst case scenario.
Comparison 3 Sensitivity analyses for Cisapride vs placebo, Outcome 3 Change in outcome definition: 'any symptoms' vs 'no symptoms' at end of treatment.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 'Worse, same or slight improvement' vs 'moderate or excellent improvement' Show forest plot | 7 | 236 | Odds Ratio (M‐H, Random, 95% CI) | 0.34 [0.10, 1.19] |
| 2 Reflux index Show forest plot | 5 | 176 | Mean Difference (IV, Random, 95% CI) | ‐6.49 [‐10.13, ‐2.85] |
| 3 Adverse events Show forest plot | 4 | 190 | Odds Ratio (M‐H, Random, 95% CI) | 1.86 [0.88, 3.93] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 'Worse, same or slight improvement' vs 'moderate or excellent improvement' Show forest plot | 1 | 50 | Odds Ratio (M‐H, Random, 95% CI) | 3.26 [0.93, 11.38] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Best case scenario Show forest plot | 7 | 290 | Odds Ratio (M‐H, Random, 95% CI) | 0.21 [0.08, 0.54] |
| 2 Worst case scenario Show forest plot | 7 | 290 | Odds Ratio (M‐H, Random, 95% CI) | 0.70 [0.18, 2.65] |
| 3 Change in outcome definition: 'any symptoms' vs 'no symptoms' at end of treatment Show forest plot | 4 | 139 | Odds Ratio (M‐H, Random, 95% CI) | 0.19 [0.07, 0.51] |
