Scolaris Content Display Scolaris Content Display

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 1 Any stroke: fatal and non‐fatal.
Figures and Tables -
Analysis 1.1

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 1 Any stroke: fatal and non‐fatal.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 2 Stroke‐related death.
Figures and Tables -
Analysis 1.2

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 2 Stroke‐related death.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 3 Stroke ipsilateral to endarterectomy site.
Figures and Tables -
Analysis 1.3

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 3 Stroke ipsilateral to endarterectomy site.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 4 Death from all causes.
Figures and Tables -
Analysis 1.4

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 4 Death from all causes.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 5 Any stroke or death.
Figures and Tables -
Analysis 1.5

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 5 Any stroke or death.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 6 Occlusion of the artery operated on.
Figures and Tables -
Analysis 1.6

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 6 Occlusion of the artery operated on.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 7 Rupture/haemorrhage of endarterectomy site.
Figures and Tables -
Analysis 1.7

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 7 Rupture/haemorrhage of endarterectomy site.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 8 Infection of the endarterectomy site.
Figures and Tables -
Analysis 1.8

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 8 Infection of the endarterectomy site.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 9 Cranial nerve palsy.
Figures and Tables -
Analysis 1.9

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 9 Cranial nerve palsy.

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 10 Complication with return to theatre.
Figures and Tables -
Analysis 1.10

Comparison 1 Patch versus no patch: perioperative complications < 30 days, Outcome 10 Complication with return to theatre.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 1 Any stroke: fatal and non‐fatal.
Figures and Tables -
Analysis 2.1

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 1 Any stroke: fatal and non‐fatal.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 2 Stroke‐related death.
Figures and Tables -
Analysis 2.2

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 2 Stroke‐related death.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 3 Stroke ipsilateral to endarterectomy site.
Figures and Tables -
Analysis 2.3

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 3 Stroke ipsilateral to endarterectomy site.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 4 Death from all causes.
Figures and Tables -
Analysis 2.4

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 4 Death from all causes.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 5 Any stroke or death.
Figures and Tables -
Analysis 2.5

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 5 Any stroke or death.

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 6 Restenosis/occlusion of the operated artery.
Figures and Tables -
Analysis 2.6

Comparison 2 Patch versus no patch: outcomes at end of follow up, Outcome 6 Restenosis/occlusion of the operated artery.

Table 1. Number of cases lost to follow up

Study

Total patients

Total operations

Patch lost at 30 days

Patch lost at end

Primary lost at 30 days

Primary lost at end

Number of exclusions

Crossover patch ‐ non

Crossover non ‐ patch

AbuRahma 1996

357

399

0

0

0

0

4

0

0

Al‐Rawi 2006l

315

338

0

7

0

8

10

Data not available

Data not available

Eikelboom 1988

126

129

0

10 patients lost to doppler FU but not clinical FU

0

7 to doppler FU but not clinical FU

0

3

3

Katz 1994

87

100

0

5

0

7

0

0

0

Lord 1989

123

140

0

0

0

0

4

Between 0 and 4

Between 0 and 4

Mannheim 2005

404

422

0

Data not available

0

Data not available

Data not available

0

0

Myers 1994

136 (109 after exclusion of 27 patients undergoing obligatory vein patching)

152 (122 analysed as 30 operations got obligatory vein patches)

0

6

0

8

30 operations underwent obligatory vein patch closure and 16 patients had both sides done (total 46)

0

0

Pratesi 1986

100

100

Data not available

Data not available

Data not available

Data not available

Data not available

Data not available

Data not available

Ranaboldo 1993

199

213

0

5

0

12

0

0

0 at 30‐day FU but 4 at 1‐year FU

Vleeschauwer 1987

126

174

0

Data not available

0

Data not available

0

0

0

FU: follow up

Figures and Tables -
Table 1. Number of cases lost to follow up
Comparison 1. Patch versus no patch: perioperative complications < 30 days

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Any stroke: fatal and non‐fatal Show forest plot

8

1769

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.57 [0.31, 1.03]

1.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.08, 1.72]

1.2 Synthetic patch

3

837

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.23 [0.50, 3.07]

1.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.29 [0.11, 0.74]

2 Stroke‐related death Show forest plot

7

1441

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.47 [0.05, 4.56]

2.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.91 [0.06, 14.73]

2.2 Synthetic patch

2

509

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.00, 6.46]

3 Stroke ipsilateral to endarterectomy site Show forest plot

7

1201

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.31 [0.15, 0.63]

3.1 Venous patch

3

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.39 [0.09, 1.75]

3.2 Synthetic patch

1

100

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.53 [0.05, 5.19]

3.3 Synthetic or venous patch

3

752

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.27 [0.11, 0.62]

4 Death from all causes Show forest plot

9

1869

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.62 [0.18, 2.09]

4.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.79 [0.18, 17.57]

4.2 Synthetic patch

3

837

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.14 [0.00, 7.15]

4.3 Synthetic or venous patch

3

686

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.48 [0.10, 2.24]

5 Any stroke or death Show forest plot

8

1769

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.58 [0.33, 1.01]

5.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.55 [0.13, 2.25]

5.2 Synthetic patch

3

837

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.10 [0.45, 2.69]

5.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.15, 0.78]

6 Occlusion of the artery operated on Show forest plot

7

1435

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.18 [0.08, 0.41]

6.1 Venous patch

2

255

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.12 [0.01, 1.99]

6.2 Synthetic patch

2

428

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.33 [0.06, 1.95]

6.3 Synthetic or venous patch

3

752

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.16 [0.06, 0.42]

7 Rupture/haemorrhage of endarterectomy site Show forest plot

9

2031

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.24 [0.61, 2.54]

7.1 Venous patch

3

429

Peto Odds Ratio (Peto, Fixed, 95% CI)

6.86 [0.14, 346.63]

7.2 Synthetic patch

3

850

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.92 [0.39, 2.14]

7.3 Synthetic or venous patch

3

752

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.32 [0.56, 9.57]

8 Infection of the endarterectomy site Show forest plot

7

1563

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.09, 1.54]

8.1 Venous patch

3

429

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.2 Synthetic patch

2

522

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.38 [0.09, 1.54]

8.3 Synthetic or venous patch

2

612

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Cranial nerve palsy Show forest plot

4

1047

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.78 [0.36, 1.69]

9.1 Venous patch

1

126

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.77 [0.17, 3.50]

9.2 Synthetic patch

2

522

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.75 [0.24, 2.35]

9.3 Synthetic or venous patch

1

399

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.85 [0.19, 3.71]

10 Complication with return to theatre Show forest plot

7

1281

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.35 [0.16, 0.79]

10.1 Venous patch

3

429

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.98 [0.06, 15.64]

10.2 Synthetic patch

1

100

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.53 [0.05, 5.19]

10.3 Synthetic or venous patch

3

752

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.29 [0.12, 0.73]

Figures and Tables -
Comparison 1. Patch versus no patch: perioperative complications < 30 days
Comparison 2. Patch versus no patch: outcomes at end of follow up

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Any stroke: fatal and non‐fatal Show forest plot

7

1332

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.49 [0.27, 0.90]

1.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.42 [0.14, 1.30]

1.2 Synthetic patch

2

400

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.95 [0.59, 6.45]

1.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.25 [0.10, 0.62]

2 Stroke‐related death Show forest plot

6

1019

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.27 [0.05, 1.60]

2.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.46 [0.05, 4.52]

2.2 Synthetic patch

1

87

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.13 [0.01, 2.04]

3 Stroke ipsilateral to endarterectomy site Show forest plot

6

1141

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.32 [0.16, 0.63]

3.1 Venous patch

3

429

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.42 [0.12, 1.47]

3.2 Synthetic patch

1

100

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.53 [0.05, 5.19]

3.3 Synthetic or venous patch

2

612

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.25 [0.10, 0.62]

4 Death from all causes Show forest plot

7

1332

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.78 [0.54, 1.12]

4.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.80 [0.45, 1.42]

4.2 Synthetic patch

2

400

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.90 [0.39, 2.05]

4.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.69 [0.38, 1.26]

5 Any stroke or death Show forest plot

6

1019

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.59 [0.42, 0.84]

5.1 Venous patch

3

346

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.69 [0.40, 1.20]

5.2 Synthetic patch

1

87

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.62 [0.23, 1.66]

5.3 Synthetic or venous patch

2

586

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.51 [0.30, 0.86]

6 Restenosis/occlusion of the operated artery Show forest plot

8

1719

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.24 [0.17, 0.34]

6.1 Venous patch

3

429

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.17, 0.66]

6.2 Synthetic patch

3

678

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.46 [0.22, 0.98]

6.3 Synthetic or venous patch

2

612

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.15 [0.09, 0.25]

Figures and Tables -
Comparison 2. Patch versus no patch: outcomes at end of follow up