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Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
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Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

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Forest plot of comparison: 1 Lumiracoxib versus placebo, outcome: 1.1 Participants with at least 50% pain relief at 6 hours.
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Figure 2

Forest plot of comparison: 1 Lumiracoxib versus placebo, outcome: 1.1 Participants with at least 50% pain relief at 6 hours.

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L'Abbé plot of the four trials, with proportion achieving at least 50% pain relief over six hours with lumiracoxib 400 mg and placebo. The size of the symbol is proportional to the size of the study. Yellow = dental studies, pink = orthopaedic study
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Figure 3

L'Abbé plot of the four trials, with proportion achieving at least 50% pain relief over six hours with lumiracoxib 400 mg and placebo. The size of the symbol is proportional to the size of the study. Yellow = dental studies, pink = orthopaedic study

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Comparison 1 Lumiracoxib versus placebo, Outcome 1 Participants with at least 50% pain relief at 6 hours.
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Analysis 1.1

Comparison 1 Lumiracoxib versus placebo, Outcome 1 Participants with at least 50% pain relief at 6 hours.

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Comparison 1 Lumiracoxib versus placebo, Outcome 2 Participants using rescue medication.
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Analysis 1.2

Comparison 1 Lumiracoxib versus placebo, Outcome 2 Participants using rescue medication.

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Comparison 1 Lumiracoxib versus placebo, Outcome 3 Participants with at least one adverse event.
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Analysis 1.3

Comparison 1 Lumiracoxib versus placebo, Outcome 3 Participants with at least one adverse event.

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Comparison 1. Lumiracoxib versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief at 6 hours Show forest plot

4

580

Risk Ratio (M‐H, Fixed, 95% CI)

6.89 [4.13, 11.51]

2 Participants using rescue medication Show forest plot

3

428

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.61, 0.77]

3 Participants with at least one adverse event Show forest plot

3

460

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.42, 1.09]
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Comparison 1. Lumiracoxib versus placebo
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