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Comparison 1 Specialised antenatal care versus routine care, Outcome 1 Perinatal death.
Figuras y tablas -
Analysis 1.1

Comparison 1 Specialised antenatal care versus routine care, Outcome 1 Perinatal death.

Comparison 1 Specialised antenatal care versus routine care, Outcome 2 Extremely preterm birth (< 28 weeks' gestation).
Figuras y tablas -
Analysis 1.2

Comparison 1 Specialised antenatal care versus routine care, Outcome 2 Extremely preterm birth (< 28 weeks' gestation).

Comparison 1 Specialised antenatal care versus routine care, Outcome 3 Development of antenatal complications ‐ preterm labour.
Figuras y tablas -
Analysis 1.3

Comparison 1 Specialised antenatal care versus routine care, Outcome 3 Development of antenatal complications ‐ preterm labour.

Comparison 1 Specialised antenatal care versus routine care, Outcome 4 Preterm birth ‐ adjusted for cluster design effect (ICC 0.002).
Figuras y tablas -
Analysis 1.4

Comparison 1 Specialised antenatal care versus routine care, Outcome 4 Preterm birth ‐ adjusted for cluster design effect (ICC 0.002).

Comparison 1 Specialised antenatal care versus routine care, Outcome 5 Sensitivity analysis. Preterm birth (adjusted for cluster design effect using upper CI, ICC 0.0041).
Figuras y tablas -
Analysis 1.5

Comparison 1 Specialised antenatal care versus routine care, Outcome 5 Sensitivity analysis. Preterm birth (adjusted for cluster design effect using upper CI, ICC 0.0041).

Comparison 1 Specialised antenatal care versus routine care, Outcome 6 Very preterm birth (birth before 34 weeks' gestation).
Figuras y tablas -
Analysis 1.6

Comparison 1 Specialised antenatal care versus routine care, Outcome 6 Very preterm birth (birth before 34 weeks' gestation).

Comparison 1 Specialised antenatal care versus routine care, Outcome 7 Gestation at birth.
Figuras y tablas -
Analysis 1.7

Comparison 1 Specialised antenatal care versus routine care, Outcome 7 Gestation at birth.

Comparison 1 Specialised antenatal care versus routine care, Outcome 9 Caesarean section.
Figuras y tablas -
Analysis 1.9

Comparison 1 Specialised antenatal care versus routine care, Outcome 9 Caesarean section.

Comparison 1 Specialised antenatal care versus routine care, Outcome 13 Neonatal intensive care unit admission.
Figuras y tablas -
Analysis 1.13

Comparison 1 Specialised antenatal care versus routine care, Outcome 13 Neonatal intensive care unit admission.

Comparison 1 Specialised antenatal care versus routine care, Outcome 19 Costs associated with care.
Figuras y tablas -
Analysis 1.19

Comparison 1 Specialised antenatal care versus routine care, Outcome 19 Costs associated with care.

Comparison 1 Specialised antenatal care versus routine care, Outcome 20 Costs associated with newborn inpatient care (US $).
Figuras y tablas -
Analysis 1.20

Comparison 1 Specialised antenatal care versus routine care, Outcome 20 Costs associated with newborn inpatient care (US $).

Comparison 1 Specialised antenatal care versus routine care, Outcome 21 Number of antenatal visits.
Figuras y tablas -
Analysis 1.21

Comparison 1 Specialised antenatal care versus routine care, Outcome 21 Number of antenatal visits.

Comparison 1 Specialised antenatal care versus routine care, Outcome 27 Preterm birth ‐ all studies, unadjusted data.
Figuras y tablas -
Analysis 1.27

Comparison 1 Specialised antenatal care versus routine care, Outcome 27 Preterm birth ‐ all studies, unadjusted data.

Comparison 1. Specialised antenatal care versus routine care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Perinatal death Show forest plot

1

302

Risk Ratio (M‐H, Fixed, 95% CI)

1.25 [0.43, 3.62]

2 Extremely preterm birth (< 28 weeks' gestation) Show forest plot

1

376

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.26, 2.25]

3 Development of antenatal complications ‐ preterm labour Show forest plot

1

370

Risk Ratio (M‐H, Fixed, 95% CI)

1.29 [0.90, 1.86]

4 Preterm birth ‐ adjusted for cluster design effect (ICC 0.002) Show forest plot

3

Risk Ratio (Fixed, 95% CI)

0.87 [0.69, 1.08]

4.1 Individually randomised trials

2

Risk Ratio (Fixed, 95% CI)

0.91 [0.68, 1.22]

4.2 Cluster randomisation

1

Risk Ratio (Fixed, 95% CI)

0.81 [0.58, 1.14]

5 Sensitivity analysis. Preterm birth (adjusted for cluster design effect using upper CI, ICC 0.0041) Show forest plot

3

Risk Ratio (Fixed, 95% CI)

0.87 [0.69, 1.11]

5.1 Individually randomised trials

2

Risk Ratio (Fixed, 95% CI)

0.91 [0.68, 1.22]

5.2 Cluster randomisation

1

Risk Ratio (Fixed, 95% CI)

0.81 [0.54, 1.22]

6 Very preterm birth (birth before 34 weeks' gestation) Show forest plot

1

376

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.50, 2.21]

7 Gestation at birth Show forest plot

1

2654

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐0.30, 0.10]

8 Infection requiring intravenous antibiotics

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Caesarean section Show forest plot

1

376

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.76, 1.62]

10 Postnatal depression

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Breastfeeding

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

12 Instrumental vaginal birth

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Neonatal intensive care unit admission Show forest plot

1

302

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.34, 1.12]

14 Respiratory distress syndrome

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

15 Parameters of birth asphyxia

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

16 Complications of prematurity

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

17 Disability at childhood follow‐up

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Women's satisfaction

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Costs associated with care Show forest plot

2

604

Mean Difference (IV, Fixed, 95% CI)

‐16.67 [‐367.00, 335.67]

20 Costs associated with newborn inpatient care (US $) Show forest plot

1

290

Mean Difference (IV, Fixed, 95% CI)

‐2196.0 [‐4322.06, ‐69.94]

21 Number of antenatal visits Show forest plot

1

290

Mean Difference (IV, Fixed, 95% CI)

1.70 [0.72, 2.68]

22 Number of antenatal admissions

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Length of antenatal admissions

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

24 Length of maternal postnatal stay

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25 Length of stay in neonatal intensive care unit

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

26 Infant length of stay in hospital

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

27 Preterm birth ‐ all studies, unadjusted data Show forest plot

3

3400

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.70, 1.03]

27.1 Individual randomisation

2

746

Risk Ratio (M‐H, Fixed, 95% CI)

0.90 [0.67, 1.21]

27.2 Cluster randomisation

1

2654

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.62, 1.06]

Figuras y tablas -
Comparison 1. Specialised antenatal care versus routine care