Prophylactic systemic antibiotics to reduce morbidity and mortality in neonates with central venous catheters

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Analysis 1.1

Comparison 1 Prophylactic antibiotics vs control, Outcome 1 Mortality.

Analysis 1.2

Comparison 1 Prophylactic antibiotics vs control, Outcome 2 Proven bacterial septicaemia.

Analysis 1.3

Comparison 1 Prophylactic antibiotics vs control, Outcome 3 Proven or suspected bacterial septicaemia.

Analysis 1.4

Comparison 1 Prophylactic antibiotics vs control, Outcome 4 Number of resistant organisms colonising study patients.

Comparison 1. Prophylactic antibiotics vs control

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality Show forest plot	3	271	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.31, 1.51]

1.1 Mortality to hospital discharge	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.15, 6.34]
1.2 Mortality timing not specified	2	218	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.26, 1.52]
2 Proven bacterial septicaemia Show forest plot	2	201	Risk Ratio (M‐H, Fixed, 95% CI)	0.38 [0.18, 0.82]

3 Proven or suspected bacterial septicaemia Show forest plot	2	201	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.20, 0.78]

4 Number of resistant organisms colonising study patients Show forest plot	2	123	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

Comparison 1. Prophylactic antibiotics vs control