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Comparison 1 Primary outcome measures, Outcome 1 Late death (at end of scheduled follow up).
Figuras y tablas -
Analysis 1.1

Comparison 1 Primary outcome measures, Outcome 1 Late death (at end of scheduled follow up).

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Comparison 1 Primary outcome measures, Outcome 2 Late death or disability or dependency (at end of scheduled follow up).
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Analysis 1.2

Comparison 1 Primary outcome measures, Outcome 2 Late death or disability or dependency (at end of scheduled follow up).

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Comparison 2 Secondary outcome measures, Outcome 1 Early death (within one month of randomisation).
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Analysis 2.1

Comparison 2 Secondary outcome measures, Outcome 1 Early death (within one month of randomisation).

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Comparison 2 Secondary outcome measures, Outcome 2 Length of stay.
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Analysis 2.2

Comparison 2 Secondary outcome measures, Outcome 2 Length of stay.

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Comparison 2 Secondary outcome measures, Outcome 3 Discharged.
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Analysis 2.3

Comparison 2 Secondary outcome measures, Outcome 3 Discharged.

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Comparison 2 Secondary outcome measures, Outcome 4 Systolic blood pressure (mm Hg).
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Analysis 2.4

Comparison 2 Secondary outcome measures, Outcome 4 Systolic blood pressure (mm Hg).

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Comparison 2 Secondary outcome measures, Outcome 5 Diastolic blood pressure (mm Hg).
Figuras y tablas -
Analysis 2.5

Comparison 2 Secondary outcome measures, Outcome 5 Diastolic blood pressure (mm Hg).

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Comparison 2 Secondary outcome measures, Outcome 6 Mean arterial blood pressure (mm Hg).
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Analysis 2.6

Comparison 2 Secondary outcome measures, Outcome 6 Mean arterial blood pressure (mm Hg).

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Comparison 2 Secondary outcome measures, Outcome 7 Serious adverse events (requiring withdrawal of the treatment).
Figuras y tablas -
Analysis 2.7

Comparison 2 Secondary outcome measures, Outcome 7 Serious adverse events (requiring withdrawal of the treatment).

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Comparison 2 Secondary outcome measures, Outcome 8 Minor adverse events (not requiring withdrawal of the treatment).
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Analysis 2.8

Comparison 2 Secondary outcome measures, Outcome 8 Minor adverse events (not requiring withdrawal of the treatment).

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Comparison 1. Primary outcome measures

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Late death (at end of scheduled follow up) Show forest plot

6

1274

Odds Ratio (M‐H, Random, 95% CI)

1.03 [0.78, 1.36]

2 Late death or disability or dependency (at end of scheduled follow up) Show forest plot

3

750

Odds Ratio (M‐H, Random, 95% CI)

0.94 [0.70, 1.26]
Figuras y tablas -
Comparison 1. Primary outcome measures
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Comparison 2. Secondary outcome measures

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Early death (within one month of randomisation) Show forest plot

3

453

Odds Ratio (M‐H, Random, 95% CI)

1.10 [0.63, 1.91]

2 Length of stay Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

3 Discharged Show forest plot

3

283

Odds Ratio (M‐H, Random, 95% CI)

1.04 [0.64, 1.69]

4 Systolic blood pressure (mm Hg) Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Subtotals only

4.1 24 hour on treatment

2

701

Mean Difference (IV, Random, 95% CI)

1.50 [‐2.02, 5.02]

4.2 48 hour on treatment

2

656

Mean Difference (IV, Random, 95% CI)

‐1.54 [‐9.99, 6.90]

5 Diastolic blood pressure (mm Hg) Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Subtotals only

5.1 24 hour on treatment

2

701

Mean Difference (IV, Random, 95% CI)

1.16 [‐1.50, 3.82]

5.2 48 hour on treatment

2

656

Mean Difference (IV, Random, 95% CI)

‐0.88 [‐5.42, 3.67]

6 Mean arterial blood pressure (mm Hg) Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Subtotals only

6.1 24 hour on treatment

2

701

Mean Difference (IV, Random, 95% CI)

1.41 [‐0.79, 3.62]

6.2 48 hour on treatment

2

656

Mean Difference (IV, Random, 95% CI)

‐1.12 [‐7.20, 4.96]

7 Serious adverse events (requiring withdrawal of the treatment) Show forest plot

3

442

Odds Ratio (M‐H, Random, 95% CI)

1.52 [0.53, 4.35]

8 Minor adverse events (not requiring withdrawal of the treatment) Show forest plot

3

492

Odds Ratio (M‐H, Random, 95% CI)

1.99 [0.96, 4.11]
Figuras y tablas -
Comparison 2. Secondary outcome measures
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