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Vaksin untuk selesema biasa

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Background

The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, sneezing, cough, malaise, sore throat, and fever (usually < 37.8º C). The widespread morbidity caused by the common cold worldwide is related to its ubiquitousness rather than its severity. The development of vaccines for the common cold has been difficult because of antigenic variability of the common cold virus and the indistinguishable multiple other viruses and even bacteria acting as infective agents. There is uncertainty regarding the efficacy and safety of interventions for preventing the common cold in healthy people. This is an update of a Cochrane review first published in 2011 and previously updated in 2013.

Objectives

To assess the clinical effectiveness and safety of vaccines for preventing the common cold in healthy people.

Search methods

We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (September 2016), MEDLINE (1948 to September 2016), Embase (1974 to September 2016), CINAHL (1981 to September 2016), and LILACS (1982 to September 2016). We also searched three trials registers for ongoing studies and four websites for additional trials (February 2017). We included no language or date restrictions.

Selection criteria

Randomised controlled trials (RCTs) of any virus vaccines compared with placebo to prevent the common cold in healthy people.

Data collection and analysis

Two review authors independently evaluated methodological quality and extracted trial data. We resolved disagreements by discussion or by consulting a third review author.

Main results

We found no additional RCTs for inclusion in this update. This review includes one RCT dating from the 1960s with an overall high risk of bias. The RCT included 2307 healthy participants, all of whom were included in analyses. This trial compared the effect of an adenovirus vaccine against placebo. No statistically significant difference in common cold incidence was found: there were 13 (1.14%) events in 1139 participants in the vaccines group and 14 (1.19%) events in 1168 participants in the placebo group (risk ratio 0.95, 95% confidence interval 0.45 to 2.02; P = 0.90). No adverse events related to the live vaccine were reported. The quality of the evidence was low due to limitations in methodological quality and a wide 95% confidence interval.

Authors' conclusions

This Cochrane Review was based on one study with low‐quality evidence. We found no conclusive results to support the use of vaccines for preventing the common cold in healthy people compared with placebo. We identified a need for well‐designed, adequately powered RCTs to investigate vaccines for the common cold in healthy people. Any future trials on medical treatments for preventing the common cold should assess a variety of virus vaccines for this condition. Outcome measures should include common cold incidence, vaccine safety, and mortality related to the vaccine.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Vaksin untuk mencegah selesema biasa

Soalan ulasan

Kita telah melihat sama ada vaksin boleh membantu mencegah selesema biasa.

Latar belakang

Selesema biasa adalah disebabkan oleh jangkitan virus pada saluran pernafasan atas, dan biasanya menjadi lebih baik apabila virus tersebut mati. Orang yang mempunyai selesema merasa kurang sihat, mempunyai hidung berair, hidung tersumbat, bersin, dan batuk dengan atau tanpa sakit tekak, dan suhu yang sedikit tinggi. Rawatan‐rawatan adalah bertujuan untuk melegakan gejala.

Di peringkat global, selsema menyebabkan penyakit yang meluas. Ia adalah sukar untuk menghasilkan vaksin untuk mencegah selesema biasa kerana banyak virus yang terlibat. Kesan vaksin untuk mencegah selesema biasa pada orang yang sihat masih tidak diketahui.

Tarikh carian

Untuk kemaskini ini, kami telah membuat carian kajian sehingga 2 September 2016.

Ciri‐ciri kajian

Kami mendapati tiada kajian baru dalam kemas kini ini. Ulasan ini termasuk satu kajian rawak terkawal yang dikenal pasti sebelum ini pada tahun 1965. Kajian ini melibatkan 2307 orang yang sihat di kemudahan latihan untuk Tentera Laut Amerika Syarikat dan dinilai kesan satu vaksin adenovirus yang hidup (dilemahkan) berbanding dengan satu vaksin yang palsu (plasebo).

Sumber pembiayaan kajian

Kajian ini dibiayai oleh institusi kerajaan.

Keputusan‐keputusan utama

Tiada perbezaan dalam kekerapan selesema biasa yang berlaku di antara mereka yang menerima vaksin berbanding dengan mereka yang menerima vaksin palsu. Tiada kesan buruk yang dilaporkan berkaitan dengan vaksin. Namun demikian, disebabkan oleh bilangan orang yang termasuk dalam kajian ini dan nombor selesema yang rendah, serta kelemahan dalam reka bentuk kajian, keyakinan kami terhadap keputusan ini adalah rendah. Penyelidikan yang selanjutnya mungkin boleh menjelaskan jika vaksin dapat mencegah selesema biasa, disebabkan oleh bukti terkini tidak menyokong penggunaan vaksin adenovirus untuk mencegah selesema biasa dalam orang yang sihat.

Kualiti bukti

Kami telah menilai kualiti bukti sebagai rendah kerana berisiko tinggi berat sebelah dan nombor orang yang termasuk dalam kajian dan nombor selesema yang rendah, yang mengakibatkan ketidaktepatan.

Authors' conclusions

Implications for practice

This Cochrane Review update found very limited evidence on the effects of vaccines for the common cold in healthy people. We included only one randomised controlled trial, which did not report differences between comparison groups. Review findings were based on only one trial assessed as providing low‐quality evidence at high risk of bias and with imprecise estimates. Griffin 1970 involved 2307 participants and assessed adenovirus vaccine compared with placebo.

We found insufficient evidence to support the use of vaccines for the common cold. Prescription of virus vaccines for preventing the common cold in healthy people can neither be supported nor rejected, unless new evidence from large, high‐quality trials alters this conclusion. This Cochrane Review does not provide evidence about other virus vaccines for preventing the common cold in healthy people.

Implications for research

This Cochrane Review update highlights the need for well‐designed, high‐quality randomised trials to assess the effectiveness and safety of virus vaccines to prevent the common cold in healthy people. Future trials should include outcomes such as common cold incidence, vaccine safety, mortality related to the vaccine, and adverse events related to vaccine administration. Future trials should be conducted by independent researchers and reported according to CONSORT guidelines (Ioannidis 2004; Moher 2010), and using the Foundation of Patient‐Centered Outcomes Research recommendations (Anonymous 2012; Gabriel 2012).

Summary of findings

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Summary of findings for the main comparison. Virus vaccines compared to placebo for preventing the common cold in healthy people

Virus vaccines compared to placebo for preventing the common cold in healthy people

Patient or population: healthy people
Settings: outpatients at Great Lakes Naval Training Center
Intervention: virus vaccines for preventing the common cold¹
Comparison: placebo

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Placebo

Virus vaccines for preventing the common cold

Incidence of the common cold
Number of participants with common cold by group
Follow‐up: mean 9 weeks

Study population

RR 0.95
(0.45 to 2.02)

2307
(1 study)²

⊕⊕⊝⊝
low³ ⁴

12 per 1000

11 per 1000
(5 to 24)

Vaccine safety

The study stated that there were no adverse events related to the vaccine.

2307
(1 study)²

⊕⊕⊝⊝
low³ ⁵

Mortality related to the vaccine ‐ not reported

See comments

See comments

See comments

See comments

See comments

The included study did not report this outcome.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RR: risk ratio

GRADE Working Group grades of evidence.
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1Adenovirus vaccine used for preventing the common cold.
2Griffin 1970.
3Downgraded one level due to high risk of bias for this outcome.
4Downgraded one level due to imprecision: few events (N = 27) and wide 95% confidence interval.
5Downgraded one level due to imprecision: zero events reported in a narrative fashion.

Background

 

Description of the condition

There are no standardised definitions for a common cold (see Appendix 1). The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, and sneezing, and sometimes cough, malaise, sore throat, and fever (usually < 100º F). A temperature of 100º F (37.8º C) or higher for three to four days is typically associated with influenza and other respiratory diseases (Appendix 2) (DDCP 2010; Heikkinen 2003). While benign in nature, the common cold is the most frequent illness experienced in humans. Children experience six to 11 upper respiratory tract infections per year (Evans 1997; Leder 2003; Nelson 2000), and adults experience two to four episodes per year (Evans 1997; Grüber 2008; Harrison 2008). Because it causes frequent absences from school and work, the common cold has become a significant economic burden (Glezen 2000; Hall 2001; Henrickson 1994; Henrickson 2003); the cost in the United States is estimated at more than USD 60 billion each year (Poland 2009). Furthermore, bacterial complications can lead to morbidity and mortality (Thompson 2003; Wat 2004). 

The aetiology of the common cold is diverse (Appendix 3) (Heikkinen 2003). Children, the elderly, and other age groups with comorbidities such as prematurity, chronic lung diseases (chronic obstructive pulmonary disease), congenital heart disease, and asthma are more prone to viral infections that cause the common cold, such as respiratory syncytial virus (RSV), rhinovirus, parainfluenza, coronavirus, and adenovirus (non‐polio) (Edlmayr 2009; Jackson 2008; Krasinski 1985; Peltola 2008). Human rhinovirus (HRV) is responsible for 50% to 80% of common colds and is an important cause of morbidity, reduced productivity, and inappropriate use of antibiotics and over‐the‐counter medications. In humans, the coronavirus (HCoV 229E) causes the common cold by infecting the upper respiratory tract. This is mainly encountered in children, and re‐infection occurs in adults (Eriksson 2006). The primary factors that contribute to the spread of this disease are poor hand hygiene, overcrowding, and captive populations (schools and daycare centres) (Harrison 2008). 

Description of the intervention

Treatment of the common cold is symptomatic. Studies have shown that simple preventive measures are important but may be difficult to enforce practically (Jefferson 2011). Another method of prevention could be vaccination. 

The development of vaccines for the common cold has been challenging because of multiple aetiologies, Poland 2009, and antigenic variability of the common cold viruses (Bembridge 1998; Hussell 1998). In the case of rhinovirus, there are over 167 different rhinoviral serotypes (Ren 2017). For this reason, it is difficult to create a vaccine that can give total protection. However, the future for vaccines for the common cold looks promising, considering the current knowledge of the full genomes of HRV serotypes (Palmemberg 2009). Immune responses are triggered whenever a person is infected with the same virus but with different antigenic molecules (Tobin 2008). 

One of the most common causes of respiratory diseases are rhinoviruses. A recombinant vaccine has been reported, produced with rhinovirus‐derived VP1, a surface protein that is critically involved in the infection of respiratory cells, and a non‐allergenic peptide of the major grass pollen type allergen Ph1 p1 (Edlmayr 2009).

Adenovirus is a commonly recognised pathogen of the upper respiratory tract and has been particularly common in captive populations (Binn 2007). Adenovirus serotype 4 (Ad4) and serotype 7 vaccines were used during immunisation programmes starting in 1971. Unfortunately, their interruption triggered the re‐emergence of adenovirus‐produced diseases in crowded locations. An example of this reappearance was documented in United States military training sites in 1999, where Ad4 accounted for 98% of all diagnoses (Russell 2006). 

Epidemiological and clinical studies have revealed important changes with regard to clinical adenovirus infection, including alterations in its antigenic presentation, geographical distribution, and virulence (Gray 2007). Adenoviral vaccines delivered orally have been used for decades to prevent respiratory illnesses. New studies have concluded that these vaccines are safe and have brought about a good immune response in the studied populations.

Respiratory syncytial virus causes approximately 5% of common colds in adults (Heikkinen 2003). The vaccine development for RSV has had some problems due to antigenic variability, especially in proteins F and G. People who were vaccinated with the formalin‐inactivated vaccine displayed X‐ray evidence of severe pneumonia and bronchiolitis due to pulmonary Arthus reaction and a process of immunopotentiation. This process was induced by a T helper (Th)‐2 and Th17 T cell responses with the enrolment of T cells, neutrophils, and eosinophils causing inflammation and tissue damage (Rey‐Jurado 2017). Where an effective vaccine can be offered, it should be administered to children younger than six months of age, when immune systems are still immature. For this reason another approach is the development of a vaccine for maternal immunisation as it has been demonstrated that RSV‐neutralising antibodies are transferred efficiently through the placenta from the pregnant woman to the newborn (Munoz 2003). Furthermore, a phase II clinical trial has found that a recombinant F nanoparticle vaccine formulation reduces the incidence of RSV infection when compared to placebo (the incidence was 11% versus 21%, respectively) in healthy women of childbearing age (Glenn 2016).

Vaccines for parainfluenza (HPIV3 cp45) are safe and immunogenic in seronegative children aged between six and 18 months (Belshe 2004a). The vaccine has also demonstrated less risk of transmission than others (wt HPIV3), making it possible to develop more randomised trials. Bovine parainfluenza virus vaccines are also being developed, which have been well‐tolerated, effective, and immunogenic in infants (Belshe 2004b).  

How the intervention might work

Almost all vaccines work by inducing antibodies in the serum to interfere with microbial invasion of the bloodstream, or in the mucosa, and to block adherence of pathogens to epithelial cells (Pichichero 2009). To protect the body, antibodies must be efficient, neutralising agents or have opsonisation and phagocytosis properties. Correlates of protection after vaccination are sometimes absolute quantities, but are often relative. Most infections are prevented at a particular response level, but some could occur above that level because of a large challenge dose or deficient host factors. There may be more than one correlate of protection for a disease; authors refer to these as "co‐correlates". Either the effector or central memory may co‐correlate with protection. Cell‐mediated immunity may also operate as a correlate or co‐correlate of protection against disease, rather than against infection (Plotkin 2008). Some studies suggest that vaccines that mimic natural infection and take into account the structure of pathogens seem to be effective in inducing long‐term protective immunity (Kang 2009).  

Why it is important to do this review

  1. Common cold vaccines would reduce the prevalence of this disease in more than 25 million people with upper respiratory tract infections each year (Gonzales 2001). 

  2. The common cold results in an important economic burden with over 189 million missed school days, Roxas 2007, and 8 million to 20 million days of restricted activity (Adams 1999). 

  3. If randomised controlled trials demonstrate that there is a vaccine providing efficacy and safety to prevent the common cold, scientists could continue research in this area.

Objectives

To assess the clinical effectiveness and safety of vaccines for preventing the common cold in healthy people.

Methods

Criteria for considering studies for this review

Types of studies

Randomised controlled trials (RCTs). We did not apply limits with respect to follow‐up periods.

Types of participants

Healthy people aged between 6 months and 90 years.

Types of interventions

Any vaccine that prevents the common cold, which protects against RSV, rhinovirus, parainfluenza, or adenovirus (non‐polio), irrespective of dose, schedule, or administration route, versus placebo. We excluded trials on the prevention of influenza A and B because influenza and the common cold are two different diseases (Jefferson 2012). See Appendix 3 for details.

Types of outcome measures

Primary outcomes

  1. Incidence of the common cold after vaccination, regardless of the causal agent determined by laboratory or clinical examination.

  2. Vaccine safety, i.e. adverse events ("any untoward medical occurrence that may present during treatment with a pharmaceutical product but which does not necessarily have a causal relationship with this treatment") (Nebeker 2004); and adverse drug reactions ("a response to a drug which is noxious, uninitiated and which occurs at doses normally used in men for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiologic functions") (Nebeker 2004).

  3. Mortality related to the vaccine.

Secondary outcomes

We did not consider secondary outcomes.

Search methods for identification of studies

Electronic searches

We searched the following databases up to 2 September 2016:

  • CENTRAL (the Cochrane Central Register of Controlled Trials), which contains the Cochrane Acute Respiratory Infections Specialised Register (CENTRAL; August 2016, Issue 8), in the Cochrane Library (searched 2 September); using the strategy in Appendix 4;

  • MEDLINE via Ovid (from 1948 to 2 September 2016) using the strategy in Appendix 5;

  • Embase via Elsevier (from 1974 to 2 September 2016) using the strategy in Appendix 6;

  • CINAHL via EBSCO (from 1981 to 2 September 2016) using the strategy in Appendix 7; and

  • LILACS via BIREME (from 1982 to 2 September 2016) using the strategy in Appendix 8.

We used the Cochrane Highly Sensitive Search Strategy to identify randomised trials in MEDLINE: sensitivity‐ and precision‐maximising version (2008 revision); Ovid format (Lefebvre 2011). We adapted the search strategy to search Embase, CINAHL, and LILACS.

We searched the following trial registries on 2 February 2017:

We did not restrict the results by language, dates, or publication status (published, unpublished, in press, or in progress).

Searching other resources

We checked the reference lists of all relevant trials and identified reviews. We searched the following websites for trials on 2 February 2017:

  1. US Food and Drug Administration (www.fda.gov);

  2. European Medicines Agency (www.emea.europa.eu);

  3. Medicines & Healthcare Products Regulatory Agency (www.mhra.gov.uk/index.htm);

  4. Evidence in Health and Social Care (www.evidence.nhs.uk/).

Data collection and analysis

Selection of studies

Two review authors (MJMZ, JVAF) independently screened the titles and abstracts of studies identified as a result of the search for possible inclusion in the review. We retrieved full‐text reports of potentially relevant studies. Two review authors (MJMZ, JVAF) independently screened the full texts to identify studies for inclusion and identified and recorded reasons for exclusion of the ineligible studies. Any disagreements were resolved through discussion or by consulting a third review author (DSR) when needed. We identified and excluded duplicates and collated multiple reports of the same study so that each study, rather than each report, was the unit of interest in the review. We recorded the selection process in sufficient detail to complete a PRISMA flow diagram and Characteristics of included studies table (Moher 2009). We imposed no language restrictions.

Data extraction and management

We used a data collection form for study characteristics and outcome data that we had piloted on at least one study in the review. Two review authors (DSR, CVG) extracted study characteristics from the included studies. We extracted the following study characteristics.

  1. Methods: study design, total duration of study, details of any 'run in' period, number of study centres and location, study setting, withdrawals, and date of study.

  2. Participants: N, mean age, age range, gender, severity of condition, diagnostic criteria, baseline lung function, smoking history, inclusion criteria, and exclusion criteria.

  3. Interventions: intervention, comparison, concomitant medications, and excluded medications.

  4. Outcomes: primary and secondary outcomes specified and collected, and time points reported.

  5. Notes: funding for trial, and notable conflicts of interest of trial authors.

Two review authors (DSR, CVG) independently extracted outcome data from the included studies. We had planned to note in the Characteristics of included studies table if outcome data were not reported in a usable way. We had planned to resolve disagreements by consensus or by involving a third review author (RH). One review author (DSR) transferred data into the Review Manager 5 file (RevMan 2014). We double‐checked that the data were entered correctly by comparing the data presented in the systematic review with the study report. A second review author (MJMZ) spot‐checked study characteristics for accuracy against the trial report.

Assessment of risk of bias in included studies

Three review authors (DSR, CVG, RH) independently assessed risk of bias for each study using the criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2011). We resolved any disagreements by discussion or by involving another review author (MJMZ). We assessed the risk of bias according to the following domains.

  1. Random sequence generation.

  2. Allocation concealment.

  3. Blinding of participants and personnel.

  4. Blinding of outcome assessment.

  5. Incomplete outcome data.

  6. Selective outcome reporting.

  7. Other bias.

We graded each potential source of bias as high, low, or unclear and provided quotes from the study report together with a justification for our judgement in the 'Risk of bias' table. Where necessary, we considered blinding separately for different key outcomes.

Measures of treatment effect

We calculated the risk ratio (RR) with 95% confidence intervals (CIs) for incidence of the common cold.

We entered outcome data for the study into a data table in Review Manager 5 to calculate the treatment effects (RevMan 2014). We used RR for dichotomous outcomes.

Unit of analysis issues

The unit of analysis was the participant. We collected and analysed a single measurement for each outcome from each participant.

Dealing with missing data

We had planned to contact investigators or study sponsors to verify key study characteristics and to obtain missing numerical outcome data where possible (e.g. when a study was identified only as an abstract). Where this was not possible, and the missing data were thought to introduce serious bias, we planned to explore the impact of including such studies in the overall assessment of results by a sensitivity analysis.

If numerical outcome data were missing, such as standard deviations or correlation coefficients, and could not be obtained from the authors, we planned to calculate them from other available statistics such as P values, according to the methods described in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2011).

However, we did not apply these approaches because this update included only one study.

Assessment of heterogeneity

We had planned use the I² statistic to measure heterogeneity among the trials in each analysis; however, this update did not include meta‐analysis. If in future updates we identify substantial heterogeneity, we will report this and explore possible causes by prespecified subgroup analysis.

Assessment of reporting biases

We did not assess publication bias using a funnel plot because we included only one trial. For future updates, we will attempt to assess whether the review is subject to publication bias by using a funnel plot if 10 or more trials are included.

Data synthesis

We carried out statistical analysis using Review Manager 5 software (RevMan 2014). For future updates, we will summarise findings using a fixed‐effect model according the Cochrane Handbook of Systematic Reviews for Interventions (Higgins 2011).

GRADE and 'Summary of findings' tables

We created a 'Summary of findings' table using the following outcomes: incidence of the common cold, vaccine safety, and mortality. We used the five GRADE considerations (study limitations, consistency of effect, imprecision, indirectness, and publication bias) to assess the quality of the evidence as it relates to the study that contributed data (Atkins 2004). We used methods and recommendations described in Section 8.5 and Chapter 12 of the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2011), using GRADEpro GDT software (GRADEpro GDT 2014). We justified all decisions to down‐ or upgrade study quality using footnotes, and made comments to aid the reader's understanding of the review where necessary.

Subgroup analysis and investigation of heterogeneity

In subsequent updates of this review, when sufficient data are available, we plan to carry out the following subgroup analyses:

  1. children and adults;

  2. country of study; and

  3. different responses in relation to different viral agents.

We will explore sources of heterogeneity in the assessment of the primary outcome measure by subgroup analyses and meta‐regression analyses. The meta‐regression analyses will assess the effect of methodological quality (high versus low), type of virus vaccines, and participant characteristics. We will only conduct meta‐regression if 10 or more RCTs are included.

Sensitivity analysis

For future updates, we plan to conduct sensitivity analyses comparing the results using all trials as follows.

  1. Trials with high methodological quality (studies classified as having a 'low risk of bias' versus those identified as having a 'high risk of bias') (Higgins 2011).

  2. Trials that performed intention‐to‐treat versus per‐protocol analyses.

We will also evaluate the risk of attrition bias, as estimated by the percentage of participants lost. We will exclude trials with a total attrition of more than 30% or where differences between the groups exceeded 10%, or both, from meta‐analysis, but will include them in the review.

Results

Description of studies

Results of the search

For this 2016 update we assessed 221 results from our electronic searches (Figure 1). We excluded 218 records based on assessment of title and abstract. We obtained three full‐text reports, which we excluded after full‐text assessment. Consequently, we did not include any new studies for this update. Only one study was included (Griffin 1970).


Study flow diagram

Study flow diagram

Included studies

This review included one RCT involving 2307 healthy people (Griffin 1970). See the Characteristics of included studies table.

Excluded studies

In the previous review we excluded 41 studies (Belshe 1982; Belshe 1992; Belshe 2004a; Belshe 2004b; Clements 1991; DeVincenzo 2010; Doggett 1963; Dudding 1972; Falsey 1996; Falsey 2008; Fulginiti 1969; Gomez 2009; Gonzalez 2000; Greenberg 2005; Hamory 1975; Karron 1995a; Karron 1995b; Karron 1997; Karron 2003; Karron 2005; Langley 2009; Lee 2001; Lee 2004; Lin 2007; Lyons 2008; Madhi 2006; Munoz 2003; Murphy 1994; Paradiso 1994; Piedra 1995; Pierce 1968; Power 2001; Ritchie 1958; Simoes 2001; Tang 2008; Top 1971; Tristram 1993; Watt 1990; Welliver 1994; Wilson 1960; Wright 1976). In this update, we excluded three new studies: two did not evaluate the common cold as an outcome (Glenn 2016; Karron 2015), and the third study involved an intervention that was not relevant to this review (probiotics) (Kumpu 2015).

See the Characteristics of excluded studies tables.

Risk of bias in included studies

Griffin 1970 had overall low methodological quality. See Figure 2 and Figure 3.


'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages


'Risk of bias' summary: review authors' judgements about each risk of bias item for the included study

'Risk of bias' summary: review authors' judgements about each risk of bias item for the included study

Allocation

We assessed Griffin 1970 as at unclear risk of bias for random sequence generation and allocation concealment since the information provided was inadequate for judgement of this domain.

Blinding

We assessed Griffin 1970 as at low risk of bias for blinding of participants and personnel, but unclear for outcome assessor. Although a placebo was used, there could be a risk of detection bias because common cold does not require hospitalisation.

Incomplete outcome data

We assessed Griffin 1970 as at unclear risk of attrition bias because the information provided was insufficient to enable assessment of this domain.

Selective reporting

Griffin 1970 was at high risk of bias for selective reporting. The study protocol was not available, but it was clear that the published reports include all expected outcomes. However, some of the outcomes were described in a narrative fashion and did not specify incidence for each group.

Other potential sources of bias

Griffin 1970 had a high risk for other sources of bias. Participants' base characteristics were not described, and because there was no detailed information relating to assessment of selection bias, information was insufficient to evaluate if both groups were comparable.

Effects of interventions

See: Summary of findings for the main comparison Virus vaccines compared to placebo for preventing the common cold in healthy people

Results were based on one RCT (Griffin 1970, N = 2307 healthy people), which we assessed as providing low‐quality evidence. See summary of findings Table for the main comparison.

Primary outcomes

1. Incidence of the common cold

Griffin 1970 (2307 participants, 27 events) showed that adenovirus vaccine was associated with a non‐statistically significant reduction in the incidence of the common cold compared with placebo (RR 0.95, 95% CI 0.45 to 2.02; P = 0.90; Analysis 1.1). We downgraded the quality of the evidence to low due to high risk of bias and imprecision; there were few events in each group, resulting in imprecision represented by a wide 95% confidence interval.

2. Vaccine safety

Griffin 1970 reported that there were no adverse events related to the live vaccine preparation. We downgraded the quality of the evidence to low due to high risk of bias and imprecision (0 events).

3. Mortality related to vaccine

Griffin 1970 did not assess this outcome.

Discussion

Summary of main results

We included one RCT that met our inclusion criteria. Critical appraisal of Griffin 1970 did not support the use of any virus vaccines for preventing the common cold in healthy people. We did not find significant differences in the incidence of the common cold in people treated with adenovirus vaccines compared with placebo. Griffin 1970 did not evaluate main clinical outcomes such as mortality related to the vaccine. This RCT reported that there were no adverse events related to the vaccine. The relative effect of any of the vaccines for viruses that cause the common cold remains unclear.

Overall completeness and applicability of evidence

The included trial did not detect statistically significant differences between the treatment groups (Griffin 1970).

When dealing with such neutral results, we need to keep in mind that 'absence of evidence' is not 'evidence of absence' (Altman 1995; Fermi Paradox 2012). The fact that this review did not detect any differences between the intervention groups does not imply that placebo and adenovirus vaccine have the same effect on preventing the common cold. The first possible explanation is failure to determine an appropriate sample size (Green 2002; Schulz 1995), in this case resulting in small differences in the incidence of the common cold and few events in the comparison groups. In a remarkable paper from 28 years ago, Freiman 1978 suggested that "many of the therapies labelled as 'no different from control' in trials using inadequate samples, have not received a fair test" and that "concern for the probability of missing an important therapeutic improvement because of small sample sizes deserves more attention in the planning of clinical trials". Moher 1998 emphasised that "most trials with negative results did not have large enough sample sizes to detect a 25% or a 50% relative difference". Moreover, it has been suggested that the most important therapies adopted in clinical practice have shown more modest benefits (Kirby 2002).

Quality of the evidence

The results for the primary outcomes 'incidence of the common cold' and 'vaccine safety' were based on low‐quality evidence due to imprecision (low number of events and wide confidence intervals) and methodological limitations. The random sequence generation, allocation, sample size, and base characteristics of participants were not reported. Furthermore, the study may be at high risk of detection bias, since the common cold syndrome rarely requires hospitalisation, and the effect of the intervention could not be adequately evaluated. The report of adverse events was not individualised for each group.

Potential biases in the review process

In the process of performing a systematic review, there is a group of biases known as 'significance‐chasing' (Ioannidis 2010). This group includes publication bias, selective outcome reporting bias, selective analysis reporting bias, and fabrication bias (Ioannidis 2010). Publication bias represents a major threat to the validity of systematic reviews, particularly in reviews that include small trials. However, we did an exhaustive search that included many RCTs that did not evaluate common cold outcomes.

Agreements and disagreements with other studies or reviews

We found no other reviews or studies that investigated vaccines for the common cold. We excluded 11 non‐RCTs that evaluated vaccines for upper respiratory tract infections (Belshe 1982; Clements 1991; Doggett 1963; Dudding 1972; Fulginiti 1969; Hamory 1975; Karron 1997; Ritchie 1958; Watt 1990; Wilson 1960; Wright 1976). However, only one study evaluated the incidence of common cold (Ritchie 1958), while the others focused on immunologic outcomes. Ritchie 1958 prepared an "autologous vaccine" developed from the nasal secretions of 125 healthy volunteers, who were then inoculated with this product, while 75 served as a control. The results showed a lower incidence of common cold in the vaccine group than in the control group.

Study flow diagram
Figures and Tables -
Figure 1

Study flow diagram

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages
Figures and Tables -
Figure 2

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages

'Risk of bias' summary: review authors' judgements about each risk of bias item for the included study
Figures and Tables -
Figure 3

'Risk of bias' summary: review authors' judgements about each risk of bias item for the included study

Comparison 1 Adenovirus vaccines versus placebo, Outcome 1 Incidence of the common cold.
Figures and Tables -
Analysis 1.1

Comparison 1 Adenovirus vaccines versus placebo, Outcome 1 Incidence of the common cold.

Summary of findings for the main comparison. Virus vaccines compared to placebo for preventing the common cold in healthy people

Virus vaccines compared to placebo for preventing the common cold in healthy people

Patient or population: healthy people
Settings: outpatients at Great Lakes Naval Training Center
Intervention: virus vaccines for preventing the common cold¹
Comparison: placebo

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Placebo

Virus vaccines for preventing the common cold

Incidence of the common cold
Number of participants with common cold by group
Follow‐up: mean 9 weeks

Study population

RR 0.95
(0.45 to 2.02)

2307
(1 study)²

⊕⊕⊝⊝
low³ ⁴

12 per 1000

11 per 1000
(5 to 24)

Vaccine safety

The study stated that there were no adverse events related to the vaccine.

2307
(1 study)²

⊕⊕⊝⊝
low³ ⁵

Mortality related to the vaccine ‐ not reported

See comments

See comments

See comments

See comments

See comments

The included study did not report this outcome.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RR: risk ratio

GRADE Working Group grades of evidence.
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1Adenovirus vaccine used for preventing the common cold.
2Griffin 1970.
3Downgraded one level due to high risk of bias for this outcome.
4Downgraded one level due to imprecision: few events (N = 27) and wide 95% confidence interval.
5Downgraded one level due to imprecision: zero events reported in a narrative fashion.

Figures and Tables -
Summary of findings for the main comparison. Virus vaccines compared to placebo for preventing the common cold in healthy people
Comparison 1. Adenovirus vaccines versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of the common cold Show forest plot

1

2307

Risk Ratio (M‐H, Fixed, 95% CI)

0.95 [0.45, 2.02]

Figures and Tables -
Comparison 1. Adenovirus vaccines versus placebo