| 1 Total mortality Show forest plot | 14 | 139232 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 2 Total mortality (individual analysis or cluster) Show forest plot | 14 | 139232 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 2.1 Individual | 12 | 70355 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.95 [0.89, 1.00] |
| 2.2 Cluster randomisation ‐ analysis by individual | 2 | 68877 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.12 [1.04, 1.22] |
| 3 Total mortality (by allocation concealment) Show forest plot | 14 | 139232 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 3.1 Adequate allocation concealment | 3 | 18729 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.86, 1.21] |
| 3.2 Inadequate allocation concealment | 4 | 13388 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.71, 0.94] |
| 3.3 Unclear allocation concealment | 7 | 107115 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.03 [0.98, 1.09] |
| 4 Total mortality (by co‐morbidity) Show forest plot | 13 | 138010 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 4.1 No co‐morbidity | 7 | 120158 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.04 [0.99, 1.09] |
| 4.2 Co‐morbidity (hypertension and diabetes) | 6 | 17852 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.78 [0.68, 0.89] |
| 5 Total mortality (by drug treatment) Show forest plot | 13 | 139091 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.01 [0.96, 1.05] |
|
| 5.1 No drug treatment | 4 | 76589 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.12 [1.04, 1.21] |
| 5.2 Antihypertensives OR lipid‐lowering drugs | 6 | 26113 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.86 [0.78, 0.96] |
| 5.3 Antihypertensives AND lipid‐lowering drugs | 3 | 36389 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.98 [0.92, 1.06] |
| 6 Total mortality (by era) Show forest plot | 14 | 139232 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 6.1 Low rate of CVD | 7 | 18818 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.73, 1.18] |
| 6.2 High Rate of CVD | 7 | 120414 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.01 [0.96, 1.06] |
| 7 Total mortality (by age of study) Show forest plot | 14 | 139232 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.96, 1.05] |
|
| 7.1 Before 2000 | 11 | 133228 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.01 [0.96, 1.05] |
| 7.2 After 2000 | 3 | 6004 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.51, 1.60] |
| 8 Coronary heart disease mortality Show forest plot | 11 | 132564 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 9 Coronary heart disease mortality (individual analysis or cluster) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 9.1 Individual | 10 | 69102 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.96 [0.87, 1.05] |
| 9.2 Cluster randomisation ‐ analysis by individual | 1 | 63732 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.08 [0.94, 1.23] |
| 10 Coronary heart disease mortality (by allocation concealment) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 10.1 Adequate | 1 | 12866 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.72, 1.20] |
| 10.2 Inadequate | 3 | 12853 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.67, 1.07] |
| 10.3 Unclear | 7 | 107115 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.94, 1.11] |
| 11 Coronary heart disease mortality (by co‐morbidity) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 11.1 No co‐morbidity | 7 | 120845 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.94, 1.11] |
| 11.2 Co‐morbidity (hypertension or diabetes) | 4 | 11989 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.66, 1.01] |
| 12 Coronary heart disease (by drug treatment) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 12.1 No drug treatment | 1 | 1232 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.44 [0.17, 1.15] |
| 12.2 Antihypertensives OR lipid‐lowering drugs | 5 | 88079 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.89, 1.10] |
| 12.3 Antihypertensives AND lipid‐lowering drugs | 5 | 43523 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.01 [0.90, 1.13] |
| 13 Coronary heart disease (by era) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 13.1 Low rate of CVD | 4 | 12420 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.66, 1.49] |
| 13.2 High rate of CVD | 7 | 120414 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
| 14 Coronary heart disease mortality (by study age) Show forest plot | 11 | 132834 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
|
| 14.1 Before 2000 | 10 | 132693 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.92, 1.07] |
| 14.2 After 2000 | 1 | 141 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.57 [0.13, 2.50] |
| 15 Stroke mortality Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 16 Stroke mortality (by allocation concealment) Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 16.1 Adequate | 1 | 12866 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.18 [0.53, 2.64] |
| 16.2 Inadequate | 2 | 12172 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.58 [0.37, 0.91] |
| 16.3 Unclear | 4 | 31893 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.60, 1.05] |
| 17 Stroke mortality (by co‐morbidity) Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 17.1 No co‐morbidity | 4 | 45342 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.87 [0.66, 1.14] |
| 17.2 Co‐morbidity (hypertension or diabetes) | 3 | 11589 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.54 [0.36, 0.83] |
| 18 Stroke mortality (by drug treatment) Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 18.1 No drug treatment | 1 | 1232 | Odds Ratio (M‐H, Fixed, 95% CI) | 2.08 [0.19, 23.03] |
| 18.2 Antihypertensives OR lipid‐lowering drugs | 3 | 23947 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.66 [0.45, 0.97] |
| 18.3 Antihypertensives AND lipid‐lowering drugs | 3 | 31752 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.80 [0.60, 1.06] |
| 19 Stroke mortality (by era) Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 19.1 Low rate of CVD | 2 | 649 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.49 [0.17, 1.46] |
| 19.2 High rate of CVD | 5 | 56282 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.77 [0.61, 0.97] |
| 20 Stroke mortality (by study age) Show forest plot | 7 | 56931 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.60, 0.95] |
|
| 20.1 Before 2000 | 6 | 56790 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.76 [0.60, 0.95] |
| 20.2 After 2000 | 1 | 141 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.65 [0.10, 4.00] |
| 21 Fatal and non‐fatal clinical events Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Random, 95% CI) | 0.84 [0.73, 0.98] |
|
| 22 Fatal and non‐fatal clinical events (individual analysis or cluster) Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.88, 0.96] |
|
| 22.1 Individual | 8 | 57649 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.89 [0.84, 0.93] |
| 22.2 Cluster randomisation ‐ analysis by individual | 1 | 63732 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.06 [0.97, 1.17] |
| 23 Fatal and non‐fatal clinical events (by allocation concealment) Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.88, 0.96] |
|
| 23.1 Adequate | 2 | 13584 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.76, 0.88] |
| 23.2 Inadequate | 2 | 12172 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.73 [0.62, 0.86] |
| 23.3 Unclear | 5 | 95625 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.02 [0.96, 1.08] |
| 24 Fatal and non‐fatal clinical events (by co‐morbidity) Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.88, 0.96] |
|
| 24.1 No co‐morbidity | 5 | 109074 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.94 [0.90, 0.99] |
| 24.2 Co‐morbidity (hypertension or diabetes) | 4 | 12307 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.71 [0.61, 0.83] |
| 25 Fatal and non‐fatal clinical events (by drug treatment) Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.88, 0.96] |
|
| 25.1 No drug treatment | 1 | 1232 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.57 [0.33, 0.97] |
| 25.2 Antihypertensives OR lipid‐lowering drugs | 5 | 88397 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.88 [0.84, 0.93] |
| 25.3 Antihypertensives AND lipid‐lowering drugs | 3 | 31752 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.93, 1.08] |
| 26 Fatal and non‐fatal clinical events (by era) Show forest plot | 9 | 121381 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.88, 0.96] |
|
| 26.1 Low rate of CVD | 3 | 1367 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.60 [0.44, 0.84] |
| 26.2 High Rate of CVD | 6 | 120014 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.89, 0.97] |
| 27 Fatal and non‐fatal clinical events (by age of study) Show forest plot | 9 | 120011 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.89, 0.97] |
|
| 27.1 Before 2000 | 7 | 119152 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.94 [0.90, 0.98] |
| 27.2 After 2000 | 2 | 859 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.46 [0.25, 0.85] |
| 28 Smoking prevalence Show forest plot | 20 | 51586 | Odds Ratio (M‐H, Random, 95% CI) | 0.87 [0.75, 1.00] |
|
| 29 Smoking prevalence (individual analysis or cluster) Show forest plot | 20 | 51586 | Odds Ratio (M‐H, Random, 95% CI) | 0.87 [0.75, 1.00] |
|
| 29.1 Cluster randomisation ‐ analysis by cluster | 1 | 520 | Odds Ratio (M‐H, Random, 95% CI) | 0.43 [0.28, 0.64] |
| 29.2 Individual randomisation | 16 | 31506 | Odds Ratio (M‐H, Random, 95% CI) | 0.89 [0.76, 1.04] |
| 29.3 Cluster randomisation ‐ analysis by individual | 3 | 19560 | Odds Ratio (M‐H, Random, 95% CI) | 0.98 [0.89, 1.07] |
| 30 Smoking prevalence (by allocation concealment) Show forest plot | 20 | 51586 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.76, 0.82] |
|
| 30.1 Adequate allocation concealment | 4 | 12136 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.58 [0.54, 0.63] |
| 30.2 Inadequate allocation concealment | 5 | 4365 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.03 [0.91, 1.17] |
| 30.3 Unclear allocation concealment | 11 | 35085 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.89 [0.84, 0.94] |
| 31 Smoking prevalence (by co‐morbidity) Show forest plot | 15 | 49681 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.75, 0.82] |
|
| 31.1 No co‐morbidity | 15 | 49681 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.75, 0.82] |
| 32 Smoking prevalence (by drug treatment) Show forest plot | 20 | 53491 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.76, 0.83] |
|
| 32.1 No drug treatment | 9 | 10724 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.86 [0.78, 0.93] |
| 32.2 Antihypertensives OR lipid‐lowering drugs | 6 | 31599 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.72 [0.68, 0.76] |
| 32.3 Antihypertensives AND lipid‐lowering drugs | 5 | 9263 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.91 [0.83, 1.00] |
| 32.4 Co‐morbidity (hypertension or diabetes) | 5 | 1905 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.89 [0.70, 1.12] |
| 33 Smoking prevalence (by era) Show forest plot | 20 | 51586 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.76, 0.82] |
|
| 33.1 Low rate of CVD | 15 | 16120 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.79, 0.92] |
| 33.2 High rate of CVD | 5 | 35466 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.76 [0.72, 0.80] |
| 34 Smoking prevalence (by age of study) Show forest plot | 20 | 51586 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.76, 0.82] |
|
| 34.1 Study before 2000 | 15 | 50166 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.79 [0.75, 0.82] |
| 34.2 Study after 2000 | 5 | 1420 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.89 [0.68, 1.18] |
| 35 Systolic blood pressure Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 36 Systolic blood pressure (individual analysis or cluster) Show forest plot | 53 | 64809 | Mean Difference (IV, Random, 95% CI) | ‐2.71 [‐3.49, ‐1.93] |
|
| 36.1 Cluster randomisation ‐ analysis by cluster | 1 | 504 | Mean Difference (IV, Random, 95% CI) | 2.5 [‐0.79, 5.79] |
| 36.2 Individual randomisation | 45 | 38261 | Mean Difference (IV, Random, 95% CI) | ‐2.99 [‐3.87, ‐2.11] |
| 36.3 Cluster randomisation ‐ analysis by individual | 7 | 26044 | Mean Difference (IV, Random, 95% CI) | ‐1.79 [‐3.54, ‐0.04] |
| 37 Systolic blood pressure (by allocation concealment) Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 37.1 Adequate allocation concealment | 14 | 18950 | Mean Difference (IV, Fixed, 95% CI) | ‐4.32 [‐4.69, ‐3.96] |
| 37.2 Inadequate allocation concealment | 9 | 4669 | Mean Difference (IV, Fixed, 95% CI) | ‐2.03 [‐2.84, ‐1.23] |
| 37.3 Unclear allocation concealment | 30 | 41190 | Mean Difference (IV, Fixed, 95% CI) | ‐2.65 [‐3.03, ‐2.26] |
| 38 Systolic blood pressure (by co‐morbidity) Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 38.1 No co‐morbidity | 29 | 52275 | Mean Difference (IV, Fixed, 95% CI) | ‐3.70 [‐4.01, ‐3.38] |
| 38.2 Co‐morbidity (hypertension or diabetes) | 24 | 12534 | Mean Difference (IV, Fixed, 95% CI) | ‐2.81 [‐3.23, ‐2.38] |
| 39 Systolic blood pressure (by drug treatment) Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 39.1 No drug treatment | 29 | 15846 | Mean Difference (IV, Fixed, 95% CI) | ‐2.74 [‐3.19, ‐2.29] |
| 39.2 Antihypertensives OR lipid‐lowering drugs | 17 | 34517 | Mean Difference (IV, Fixed, 95% CI) | ‐3.89 [‐4.28, ‐3.51] |
| 39.3 Antihypertensives AND lipid‐lowering drugs | 7 | 14446 | Mean Difference (IV, Fixed, 95% CI) | ‐3.31 [‐3.81, ‐2.80] |
| 40 Systolic blood pressure (by era) Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 40.1 Low rate of CVD | 49 | 30562 | Mean Difference (IV, Fixed, 95% CI) | ‐3.07 [‐3.38, ‐2.75] |
| 40.2 High rate of CVD | 4 | 34247 | Mean Difference (IV, Fixed, 95% CI) | ‐3.92 [‐4.34, ‐3.51] |
| 41 Systolic blood pressure (by age of study) Show forest plot | 53 | 64809 | Mean Difference (IV, Fixed, 95% CI) | ‐3.38 [‐3.63, ‐3.13] |
|
| 41.1 Study before 2000 | 36 | 53606 | Mean Difference (IV, Fixed, 95% CI) | ‐3.59 [‐3.90, ‐3.28] |
| 41.2 Study after 2000 | 17 | 11203 | Mean Difference (IV, Fixed, 95% CI) | ‐2.97 [‐3.41, ‐2.54] |
| 42 Diastolic blood pressure Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 43 Diastolic blood pressure (individual analysis or cluster) Show forest plot | 53 | 75400 | Mean Difference (IV, Random, 95% CI) | ‐2.13 [‐2.67, ‐1.58] |
|
| 43.1 Cluster randomisation ‐ analysis by cluster | 1 | 503 | Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐2.86, 2.26] |
| 43.2 Individual randomisation | 46 | 49255 | Mean Difference (IV, Random, 95% CI) | ‐2.36 [‐2.94, ‐1.77] |
| 43.3 Cluster randomisation ‐ analysis by individual | 6 | 25642 | Mean Difference (IV, Random, 95% CI) | ‐0.79 [‐1.42, ‐0.16] |
| 44 Diastolic blood pressure (by allocation concealment) Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 44.1 Adequate concealment | 14 | 18969 | Mean Difference (IV, Fixed, 95% CI) | ‐2.38 [‐2.60, ‐2.16] |
| 44.2 Inadequate allocation concealment | 10 | 15644 | Mean Difference (IV, Fixed, 95% CI) | ‐3.70 [‐4.01, ‐3.40] |
| 44.3 Unclear allocation concealment | 29 | 40787 | Mean Difference (IV, Fixed, 95% CI) | ‐1.60 [‐1.85, ‐1.35] |
| 45 Diastolic blood pressure (by co‐morbidity) Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 45.1 No co‐morbidity | 28 | 51891 | Mean Difference (IV, Fixed, 95% CI) | ‐2.33 [‐2.52, ‐2.13] |
| 45.2 Co‐morbidity (hypertension or diabetes) | 25 | 23509 | Mean Difference (IV, Fixed, 95% CI) | ‐2.51 [‐2.73, ‐2.29] |
| 46 Diastolic blood pressure (by drug treatment) Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 46.1 No drug treatment | 28 | 15449 | Mean Difference (IV, Fixed, 95% CI) | ‐2.09 [‐2.40, ‐1.79] |
| 46.2 Antihypertensives OR lipid‐lowering drugs | 18 | 45505 | Mean Difference (IV, Fixed, 95% CI) | ‐3.05 [‐3.25, ‐2.85] |
| 46.3 Antihypertensives AND lipid‐lowering drugs | 7 | 14446 | Mean Difference (IV, Fixed, 95% CI) | ‐1.41 [‐1.70, ‐1.13] |
| 47 Diastolic blood pressure (by era) Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 47.1 Low rate of CVD | 48 | 30200 | Mean Difference (IV, Fixed, 95% CI) | ‐1.70 [‐1.90, ‐1.49] |
| 47.2 High Rate of CVD | 5 | 45200 | Mean Difference (IV, Fixed, 95% CI) | ‐3.15 [‐3.36, ‐2.94] |
| 48 Diastolic blood pressure (by age of study) Show forest plot | 53 | 75400 | Mean Difference (IV, Fixed, 95% CI) | ‐2.41 [‐2.55, ‐2.26] |
|
| 48.1 Study before 2000 | 36 | 64197 | Mean Difference (IV, Fixed, 95% CI) | ‐2.76 [‐2.93, ‐2.59] |
| 48.2 Study after 2000 | 17 | 11203 | Mean Difference (IV, Fixed, 95% CI) | ‐1.38 [‐1.67, ‐1.10] |
| 49 Blood cholesterol Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 50 Blood cholesterol (individual analysis or cluster) Show forest plot | 50 | 71776 | Mean Difference (IV, Random, 95% CI) | ‐0.24 [‐0.32, ‐0.16] |
|
| 50.1 Cluster randomisation ‐ analysis by cluster | 2 | 2475 | Mean Difference (IV, Random, 95% CI) | 0.01 [‐0.01, 0.03] |
| 50.2 Individual randomisation | 43 | 49428 | Mean Difference (IV, Random, 95% CI) | ‐0.28 [‐0.39, ‐0.17] |
| 50.3 Cluster randomisation (analysis by individual) | 5 | 19873 | Mean Difference (IV, Random, 95% CI) | 0.01 [‐0.03, 0.04] |
| 51 Blood cholesterol (by allocation concealment) Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 51.1 Adequate allocation concealment | 12 | 13108 | Mean Difference (IV, Fixed, 95% CI) | ‐0.16 [‐0.19, ‐0.13] |
| 51.2 Inadequate allocation concealment | 11 | 16876 | Mean Difference (IV, Fixed, 95% CI) | ‐0.13 [‐0.16, ‐0.10] |
| 51.3 Unclear allocation concealment | 27 | 41792 | Mean Difference (IV, Fixed, 95% CI) | ‐0.04 [‐0.06, ‐0.03] |
| 52 Blood cholesterol (by co‐morbidity) Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 52.1 No co‐morbidity | 34 | 55462 | Mean Difference (IV, Fixed, 95% CI) | ‐0.08 [‐0.09, ‐0.06] |
| 52.2 Co‐morbidity (hypertension and/or diabetes) | 16 | 16314 | Mean Difference (IV, Fixed, 95% CI) | ‐0.06 [‐0.08, ‐0.03] |
| 53 Blood cholesterol (by drug treatment) Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 53.1 No drug treatment | 31 | 19210 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.05] |
| 53.2 Antihypertensives OR lipid‐lowering drugs | 13 | 43070 | Mean Difference (IV, Fixed, 95% CI) | ‐0.06 [‐0.08, ‐0.04] |
| 53.3 Antihypertensives AND lipid‐lowering drug | 6 | 9496 | Mean Difference (IV, Fixed, 95% CI) | ‐0.18 [‐0.22, ‐0.14] |
| 54 Blood cholesterol (by era) Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 54.1 Low rate of CVD | 44 | 25887 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.05] |
| 54.2 High rate of CVD | 6 | 45889 | Mean Difference (IV, Fixed, 95% CI) | ‐0.09 [‐0.11, ‐0.07] |
| 55 Blood cholesterol (by age of study) Show forest plot | 50 | 71776 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
|
| 55.1 Study before 2000 | 33 | 66040 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.08, ‐0.06] |
| 55.2 Study after 2000 | 17 | 5736 | Mean Difference (IV, Fixed, 95% CI) | ‐0.14 [‐0.18, ‐0.10] |
