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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
Figuras y tablas -
Figure 1

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Forest plot of comparison: 1 Surgery versus control, outcome: 1.1 Overall mortality (all patients, to end of follow‐up).
Figuras y tablas -
Figure 2

Forest plot of comparison: 1 Surgery versus control, outcome: 1.1 Overall mortality (all patients, to end of follow‐up).

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At 90 days one extra death occurs following LVRS, for every 16 people operated on.
Figuras y tablas -
Figure 3

At 90 days one extra death occurs following LVRS, for every 16 people operated on.

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At 90 days one extra death occurs following LVRS, for every 27 people operated on in the low risk arm of the NETT trial.
Figuras y tablas -
Figure 4

At 90 days one extra death occurs following LVRS, for every 27 people operated on in the low risk arm of the NETT trial.

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Comparison 1 Surgery versus control, Outcome 1 Overall mortality (all patients, to end of follow‐up).
Figuras y tablas -
Analysis 1.1

Comparison 1 Surgery versus control, Outcome 1 Overall mortality (all patients, to end of follow‐up).

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Comparison 1 Surgery versus control, Outcome 2 Overall mortality (stratified by risk, to end of follow‐up).
Figuras y tablas -
Analysis 1.2

Comparison 1 Surgery versus control, Outcome 2 Overall mortality (stratified by risk, to end of follow‐up).

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Comparison 1 Surgery versus control, Outcome 3 30 Day Mortality in Non‐High Risk Patients.
Figuras y tablas -
Analysis 1.3

Comparison 1 Surgery versus control, Outcome 3 30 Day Mortality in Non‐High Risk Patients.

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Comparison 1 Surgery versus control, Outcome 4 90‐Day Mortality (all patients).
Figuras y tablas -
Analysis 1.4

Comparison 1 Surgery versus control, Outcome 4 90‐Day Mortality (all patients).

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Comparison 1 Surgery versus control, Outcome 5 90‐Day Mortality (stratified by risk).
Figuras y tablas -
Analysis 1.5

Comparison 1 Surgery versus control, Outcome 5 90‐Day Mortality (stratified by risk).

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Comparison 1 Surgery versus control, Outcome 6 Change in SGRQ (six months).
Figuras y tablas -
Analysis 1.6

Comparison 1 Surgery versus control, Outcome 6 Change in SGRQ (six months).

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Comparison 1 Surgery versus control, Outcome 7 Change in SGRQ (12 months).
Figuras y tablas -
Analysis 1.7

Comparison 1 Surgery versus control, Outcome 7 Change in SGRQ (12 months).

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Comparison 1 Surgery versus control, Outcome 8 Change in SGRQ (24 months).
Figuras y tablas -
Analysis 1.8

Comparison 1 Surgery versus control, Outcome 8 Change in SGRQ (24 months).

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Comparison 1 Surgery versus control, Outcome 9 Mean change in CRDQ domains (12 months).
Figuras y tablas -
Analysis 1.9

Comparison 1 Surgery versus control, Outcome 9 Mean change in CRDQ domains (12 months).

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Comparison 1 Surgery versus control, Outcome 10 Mean change in CRDQ domains (24 months).
Figuras y tablas -
Analysis 1.10

Comparison 1 Surgery versus control, Outcome 10 Mean change in CRDQ domains (24 months).

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Comparison 1 Surgery versus control, Outcome 11 Change in SF‐36 (six months).
Figuras y tablas -
Analysis 1.11

Comparison 1 Surgery versus control, Outcome 11 Change in SF‐36 (six months).

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Comparison 1 Surgery versus control, Outcome 12 Change in SF‐36 (12 months).
Figuras y tablas -
Analysis 1.12

Comparison 1 Surgery versus control, Outcome 12 Change in SF‐36 (12 months).

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Comparison 1 Surgery versus control, Outcome 13 Improvement in health‐related quality of life (SGRQ).
Figuras y tablas -
Analysis 1.13

Comparison 1 Surgery versus control, Outcome 13 Improvement in health‐related quality of life (SGRQ).

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Comparison 1 Surgery versus control, Outcome 14 No change/deterioration in health‐related quality of life (SGRQ).
Figuras y tablas -
Analysis 1.14

Comparison 1 Surgery versus control, Outcome 14 No change/deterioration in health‐related quality of life (SGRQ).

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Comparison 1 Surgery versus control, Outcome 15 Improvement in exercise capacity.
Figuras y tablas -
Analysis 1.15

Comparison 1 Surgery versus control, Outcome 15 Improvement in exercise capacity.

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Comparison 1 Surgery versus control, Outcome 16 No change/deterioration in exercise capacity.
Figuras y tablas -
Analysis 1.16

Comparison 1 Surgery versus control, Outcome 16 No change/deterioration in exercise capacity.

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Comparison 1 Surgery versus control, Outcome 17 Six minute walk distance (metres).
Figuras y tablas -
Analysis 1.17

Comparison 1 Surgery versus control, Outcome 17 Six minute walk distance (metres).

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Comparison 1 Surgery versus control, Outcome 18 Change in six minute walk distance (metres).
Figuras y tablas -
Analysis 1.18

Comparison 1 Surgery versus control, Outcome 18 Change in six minute walk distance (metres).

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Comparison 1 Surgery versus control, Outcome 19 FEV1 (L).
Figuras y tablas -
Analysis 1.19

Comparison 1 Surgery versus control, Outcome 19 FEV1 (L).

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Comparison 1 Surgery versus control, Outcome 20 Improvement in FEV1 % predicted.
Figuras y tablas -
Analysis 1.20

Comparison 1 Surgery versus control, Outcome 20 Improvement in FEV1 % predicted.

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Comparison 1 Surgery versus control, Outcome 21 No change/deterioration in FEV1 % predicted.
Figuras y tablas -
Analysis 1.21

Comparison 1 Surgery versus control, Outcome 21 No change/deterioration in FEV1 % predicted.

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Comparison 1 Surgery versus control, Outcome 22 Change in FEV1 (% predicted).
Figuras y tablas -
Analysis 1.22

Comparison 1 Surgery versus control, Outcome 22 Change in FEV1 (% predicted).

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Comparison 1 Surgery versus control, Outcome 23 Total lung capacity (% of predicted).
Figuras y tablas -
Analysis 1.23

Comparison 1 Surgery versus control, Outcome 23 Total lung capacity (% of predicted).

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Comparison 1 Surgery versus control, Outcome 24 Residual lung volume (% of predicted).
Figuras y tablas -
Analysis 1.24

Comparison 1 Surgery versus control, Outcome 24 Residual lung volume (% of predicted).

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Comparison 1 Surgery versus control, Outcome 25 Mean direct medical costs and total healthcare‐related costs according to time after randomisation (USD 000s).
Figuras y tablas -
Analysis 1.25

Comparison 1 Surgery versus control, Outcome 25 Mean direct medical costs and total healthcare‐related costs according to time after randomisation (USD 000s).

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Comparison 1 Surgery versus control, Outcome 26 Mean direct medical costs and total healthcare‐related costs at three years (USD 000s).
Figuras y tablas -
Analysis 1.26

Comparison 1 Surgery versus control, Outcome 26 Mean direct medical costs and total healthcare‐related costs at three years (USD 000s).

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Comparison 1 Surgery versus control, Outcome 27 Mean number of emergency‐room visits.
Figuras y tablas -
Analysis 1.27

Comparison 1 Surgery versus control, Outcome 27 Mean number of emergency‐room visits.

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Comparison 2 Laser versus stapling, Outcome 1 Post‐operative Death.
Figuras y tablas -
Analysis 2.1

Comparison 2 Laser versus stapling, Outcome 1 Post‐operative Death.

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Comparison 2 Laser versus stapling, Outcome 2 Hospital Days.
Figuras y tablas -
Analysis 2.2

Comparison 2 Laser versus stapling, Outcome 2 Hospital Days.

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Comparison 2 Laser versus stapling, Outcome 3 Persistent air leaks (>7days).
Figuras y tablas -
Analysis 2.3

Comparison 2 Laser versus stapling, Outcome 3 Persistent air leaks (>7days).

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Comparison 2 Laser versus stapling, Outcome 4 Delayed Pneumothorax.
Figuras y tablas -
Analysis 2.4

Comparison 2 Laser versus stapling, Outcome 4 Delayed Pneumothorax.

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Comparison 2 Laser versus stapling, Outcome 5 Supplemental Oxygen.
Figuras y tablas -
Analysis 2.5

Comparison 2 Laser versus stapling, Outcome 5 Supplemental Oxygen.

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Comparison 2 Laser versus stapling, Outcome 6 Quality of Life.
Figuras y tablas -
Analysis 2.6

Comparison 2 Laser versus stapling, Outcome 6 Quality of Life.

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Comparison 2 Laser versus stapling, Outcome 7 Change in FEV1 (%).
Figuras y tablas -
Analysis 2.7

Comparison 2 Laser versus stapling, Outcome 7 Change in FEV1 (%).

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Comparison 2 Laser versus stapling, Outcome 8 Change in FVC (%).
Figuras y tablas -
Analysis 2.8

Comparison 2 Laser versus stapling, Outcome 8 Change in FVC (%).

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 2 Hospital stay (days).
Figuras y tablas -
Analysis 3.2

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 2 Hospital stay (days).

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 3 Post‐operative air leak.
Figuras y tablas -
Analysis 3.3

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 3 Post‐operative air leak.

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 4 Re‐operations following persistent air leak.
Figuras y tablas -
Analysis 3.4

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 4 Re‐operations following persistent air leak.

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 5 FEV1 (% predicted).
Figuras y tablas -
Analysis 3.5

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 5 FEV1 (% predicted).

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 6 Residual volume (% predicted).
Figuras y tablas -
Analysis 3.6

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 6 Residual volume (% predicted).

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Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 7 Total lung capacity (% predicted).
Figuras y tablas -
Analysis 3.7

Comparison 3 Buttressed versus non‐buttressed stapling, Outcome 7 Total lung capacity (% predicted).

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Table 1. Search history

Search dates

Detail

1. All years to December 1999

References identified: 65
Full text articles retrieved: 13
Unique studies identified: 13
Studies failing to meet review entry criteria: 12
Studies meeting entry criteria: 1

2. December 1999 to September 2005

References identified: 253
Full text articles retrieved: 45
Unique studies identified: 11
Studies failing to meet review entry criteria: 4
Studies meeting entry criteria: 7
Total number of included studies (sum previous number & new included studies): 8

3. September 2005 to October 2006

References identified: 24
Full text articles retrieved: 7
Unique studies identified: 0 (the references were subsequent publications of either NETT 2003 or Hillerdal 2005)

4. October 2006 to September 2007

References identified: 7
Full text articles retrieved: 3
Unique studies identified: 0 (the references were subsequent publications of NETT 2003)

Figuras y tablas -
Table 1. Search history
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Table 2. Study populations

Study ID

Screened

Entered (% Screened)

Criner 1999

200

37 (19)

Geddes 2000

174

48 (28)

Goldstein 2003

328

55 (17)

Hillerdal 2005

304

106 (35)

McKenna 1996

Unclear

72 (unclear)

Miller 2005

738

93 (13)

NETT 2001

3777

1218 (32)

Stammberger 2000

Unclear

74 (unclear)

Total

5521

1520 (28)*

*Excludes data from McKenna 1996 & Stammberger 2000

Figuras y tablas -
Table 2. Study populations
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Table 3. Mortality at 90 days: NNT ‐ stratified by baseline risk status

Subgroup (OR)

Studies

N (combined)

CGER

NNT(h)

NETT defined 'high risk'

NETT 2001

140

0%

4

NETT defined 'non‐high risk'

NETT 2001

1078

25%

27

Unclear risk status

Geddes 2003; Goldstein 2003; Hillerdal 2005

285

1%

9
Figuras y tablas -
Table 3. Mortality at 90 days: NNT ‐ stratified by baseline risk status
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Table 4. Overall mortality: NNT ‐ stratified by baseline risk status

Subgroup (OR)

Studies

N (combined)

CGER

NNT (h)

NETT defined 'high risk' ‐ OR 2 (1.02 to 3.92)

NETT 2001

140

43%

6

NETT defined 'non‐high risk' ‐ 0.86 (0.64 to 1.14)

NETT 2001

1078

24%

NS

Unclear risk status ‐ OR: 2.21 (1 to 4.9)

Geddes 2000; Goldstein 2003; Hillerdal 2005; Miller 2005

285

8%

NS
Figuras y tablas -
Table 4. Overall mortality: NNT ‐ stratified by baseline risk status
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Comparison 1. Surgery versus control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Overall mortality (all patients, to end of follow‐up) Show forest plot

5

1503

Odds Ratio (M‐H, Fixed, 95% CI)

1.06 [0.83, 1.35]

2 Overall mortality (stratified by risk, to end of follow‐up) Show forest plot

5

1503

Odds Ratio (M‐H, Fixed, 95% CI)

1.06 [0.83, 1.36]

2.1 High risk

1

140

Odds Ratio (M‐H, Fixed, 95% CI)

2.0 [1.02, 3.92]

2.2 Non‐high risk

1

1078

Odds Ratio (M‐H, Fixed, 95% CI)

0.86 [0.64, 1.14]

2.3 Unclear risk status

4

285

Odds Ratio (M‐H, Fixed, 95% CI)

2.34 [0.98, 5.57]

3 30 Day Mortality in Non‐High Risk Patients Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 90‐Day Mortality (all patients) Show forest plot

4

1415

Odds Ratio (M‐H, Fixed, 95% CI)

6.57 [3.34, 12.95]

5 90‐Day Mortality (stratified by risk) Show forest plot

4

1415

Odds Ratio (M‐H, Fixed, 95% CI)

6.24 [3.24, 12.02]

5.1 High risk

1

140

Odds Ratio (M‐H, Fixed, 95% CI)

57.24 [3.38, 968.54]

5.2 Non‐high risk

1

1078

Odds Ratio (M‐H, Fixed, 95% CI)

3.65 [1.65, 8.09]

5.3 Unclear risk status

3

197

Odds Ratio (M‐H, Fixed, 95% CI)

7.08 [1.54, 32.58]

6 Change in SGRQ (six months) Show forest plot

2

SGRQ (Fixed, 95% CI)

Subtotals only

6.1 Symptoms

1

SGRQ (Fixed, 95% CI)

‐11.7 [‐20.15, ‐3.25]

6.2 Activity

1

SGRQ (Fixed, 95% CI)

‐16.8 [‐23.10, ‐10.50]

6.3 Impacts

1

SGRQ (Fixed, 95% CI)

‐13.1 [‐19.20, ‐7.00]

6.4 Total

2

SGRQ (Fixed, 95% CI)

‐13.49 [‐15.13, ‐11.84]

7 Change in SGRQ (12 months) Show forest plot

2

SGRQ units (Fixed, 95% CI)

Subtotals only

7.1 Symptoms

1

SGRQ units (Fixed, 95% CI)

‐8.8 [‐17.57, ‐0.03]

7.2 Activity

1

SGRQ units (Fixed, 95% CI)

‐17.1 [‐22.65, ‐11.55]

7.3 Impacts

1

SGRQ units (Fixed, 95% CI)

‐14.6 [‐20.05, ‐9.15]

7.4 Total

2

SGRQ units (Fixed, 95% CI)

‐13.78 [‐15.75, ‐11.80]

8 Change in SGRQ (24 months) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Symptoms

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.2 Activity

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.3 Impacts

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.4 Total

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Mean change in CRDQ domains (12 months) Show forest plot

1

CRDQ units (Fixed, 95% CI)

Totals not selected

9.1 Dypnoea

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

9.2 Fatigue

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

9.3 Mastery

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

9.4 Emotion

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Mean change in CRDQ domains (24 months) Show forest plot

1

CRDQ units (Fixed, 95% CI)

Totals not selected

10.1 Dypnoea

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

10.2 Fatigue

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

10.3 Mastery

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

10.4 Emotion

1

CRDQ units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Change in SF‐36 (six months) Show forest plot

1

SF‐346 units (Fixed, 95% CI)

Totals not selected

11.1 Physical functioning

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.2 Role physical

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.3 Bodily pain

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.4 General health

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.5 Vitality

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.6 Social functioning

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.7 Role emotional

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

11.8 Mental health

1

SF‐346 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12 Change in SF‐36 (12 months) Show forest plot

1

SF‐36 units (Fixed, 95% CI)

Totals not selected

12.1 Physical functioning

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.2 Role physical

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.3 Bodily pain

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.4 General health

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.5 Vitality

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.6 Social functioning

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.7 Role emotional

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

12.8 Mental health

1

SF‐36 units (Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Improvement in health‐related quality of life (SGRQ) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

13.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

14 No change/deterioration in health‐related quality of life (SGRQ) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

14.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

14.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

14.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

15 Improvement in exercise capacity Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

15.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

15.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

15.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

16 No change/deterioration in exercise capacity Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

16.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

16.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

16.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

17 Six minute walk distance (metres) Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

17.1 at 3 months

2

80

Mean Difference (IV, Fixed, 95% CI)

20.85 [‐9.36, 51.07]

17.2 at 6 months

1

81

Mean Difference (IV, Fixed, 95% CI)

55.0 [9.58, 100.42]

17.3 at 12 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Change in six minute walk distance (metres) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

18.1 at 3 months

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

18.2 at 6 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

18.3 at 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

18.4 at 24 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 FEV1 (L) Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

19.1 at 3 months

3

122

Mean Difference (IV, Fixed, 95% CI)

0.23 [0.08, 0.37]

19.2 at 6 months

4

248

Mean Difference (IV, Fixed, 95% CI)

0.28 [0.20, 0.35]

19.3 at 12 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

20 Improvement in FEV1 % predicted Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

20.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21 No change/deterioration in FEV1 % predicted Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

21.1 Six months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21.2 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21.3 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

22 Change in FEV1 (% predicted) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

22.1 at 3 months

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

22.2 at 6 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

22.3 at 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

22.4 at 24 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Total lung capacity (% of predicted) Show forest plot

3

122

Mean Difference (IV, Fixed, 95% CI)

‐21.70 [‐30.97, ‐12.43]

23.1 at 3 months

3

122

Mean Difference (IV, Fixed, 95% CI)

‐21.70 [‐30.97, ‐12.43]

23.2 at 6 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

23.3 at 12 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

24 Residual lung volume (% of predicted) Show forest plot

3

122

Mean Difference (IV, Fixed, 95% CI)

‐54.52 [‐75.17, ‐33.88]

24.1 at 3 months

3

122

Mean Difference (IV, Fixed, 95% CI)

‐54.52 [‐75.17, ‐33.88]

24.2 at 6 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

24.3 at 12 months

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25 Mean direct medical costs and total healthcare‐related costs according to time after randomisation (USD 000s) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

25.1 Direct Medical Costs 0‐12 Months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25.2 Total Costs 0‐12 months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25.3 Direct medical costs 13‐24 months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25.4 Total costs 13‐24 months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25.5 Direct medical costs 25‐36 months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

25.6 Total costs 25‐36 months after randomisation (USD 000s)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

26 Mean direct medical costs and total healthcare‐related costs at three years (USD 000s) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

27 Mean number of emergency‐room visits Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

27.1 0‐12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

27.2 13‐24 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

27.3 25‐36 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Surgery versus control
Ir a la tabla de la revisión
Comparison 2. Laser versus stapling

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Post‐operative Death Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

2 Hospital Days Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Persistent air leaks (>7days) Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

4 Delayed Pneumothorax Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

5 Supplemental Oxygen Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

6 Quality of Life Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

7 Change in FEV1 (%) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8 Change in FVC (%) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 2. Laser versus stapling
Ir a la tabla de la revisión
Comparison 3. Buttressed versus non‐buttressed stapling

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality

0

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Hospital stay (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Post‐operative air leak Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Re‐operations following persistent air leak Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 FEV1 (% predicted) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6 Residual volume (% predicted) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7 Total lung capacity (% predicted) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 3. Buttressed versus non‐buttressed stapling
Ir a la tabla de la revisión