Magnesium sulphate versus diazepam for eclampsia

Lelia Duley; David J Henderson‐Smart; Godfrey JA Walker; Doris Chou

doi:10.1002/14651858.CD000127.pub2

Scolaris Content Display Scolaris Content Display

Contenido relacionado

Ir a:

Revisiones y protocolos relacionados
Guías
Temas

Revisiones y protocolos relacionados

Topics

Temas

Analysis 1.1

Comparison 1 Magnesium sulphate versus diazepam, Outcome 1 Maternal death.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.2

Comparison 1 Magnesium sulphate versus diazepam, Outcome 2 Recurrence of seizures.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.3

Comparison 1 Magnesium sulphate versus diazepam, Outcome 3 Cerebrovascular accident (stroke).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.4

Comparison 1 Magnesium sulphate versus diazepam, Outcome 4 Any serious morbidity (stroke, renal failure, HELLP, DIC, pulmonary edema, cardiac arrest, or as reported.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.5

Comparison 1 Magnesium sulphate versus diazepam, Outcome 5 Renal failure.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.6

Comparison 1 Magnesium sulphate versus diazepam, Outcome 6 Liver failure.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.7

Comparison 1 Magnesium sulphate versus diazepam, Outcome 7 Coagulopathy.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.8

Comparison 1 Magnesium sulphate versus diazepam, Outcome 8 Side effects: local skin reaction.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.9

Comparison 1 Magnesium sulphate versus diazepam, Outcome 9 Pulmonary oedema.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.10

Comparison 1 Magnesium sulphate versus diazepam, Outcome 10 Pneumonia.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.11

Comparison 1 Magnesium sulphate versus diazepam, Outcome 11 Respiratory depression.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.12

Comparison 1 Magnesium sulphate versus diazepam, Outcome 12 Cardiac arrest.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.13

Comparison 1 Magnesium sulphate versus diazepam, Outcome 13 Death or any serious maternal morbidity.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.14

Comparison 1 Magnesium sulphate versus diazepam, Outcome 14 Woman admitted to intensive care unit.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.15

Comparison 1 Magnesium sulphate versus diazepam, Outcome 15 Maternal ventilation.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.16

Comparison 1 Magnesium sulphate versus diazepam, Outcome 16 Labour > 8 hours.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.17

Comparison 1 Magnesium sulphate versus diazepam, Outcome 17 Caesarean section.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.18

Comparison 1 Magnesium sulphate versus diazepam, Outcome 18 Blood loss at birth > 500 ml.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.19

Comparison 1 Magnesium sulphate versus diazepam, Outcome 19 Death of the fetus or infant.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.20

Comparison 1 Magnesium sulphate versus diazepam, Outcome 20 Preterm birth.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.21

Comparison 1 Magnesium sulphate versus diazepam, Outcome 21 Apgar scores.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.22

Comparison 1 Magnesium sulphate versus diazepam, Outcome 22 Admitted to special care baby unit (SCBU).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.23

Comparison 1 Magnesium sulphate versus diazepam, Outcome 23 Death or in SCBU > 7 days.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.24

Comparison 1 Magnesium sulphate versus diazepam, Outcome 24 Intubation at place of birth.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.1

Comparison 2 Magnesium sulphate versus diazepam (subgroups by whether randomisation before or after birth), Outcome 1 Death.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.2

Comparison 2 Magnesium sulphate versus diazepam (subgroups by whether randomisation before or after birth), Outcome 2 Recurrence of seizures.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 2.3

Comparison 2 Magnesium sulphate versus diazepam (subgroups by whether randomisation before or after birth), Outcome 3 Stroke.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.1

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 1 Maternal death.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.2

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 2 Recurrence of seizures.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.3

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 3 Any serious maternal morbidity.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.4

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 4 Perinatal death.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.5

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 5 Neonatal death.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 3.6

Comparison 3 Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation), Outcome 6 Stay in SCBU > 7 days.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 4.1

Comparison 4 Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance), Outcome 1 Maternal cardiac arrest.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 4.2

Comparison 4 Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance), Outcome 2 Maternal respiratory depression.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 4.3

Comparison 4 Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance), Outcome 3 Pneumonia.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 4.4

Comparison 4 Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance), Outcome 4 Maternal ventilation.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 1. Magnesium sulphate versus diazepam

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death Show forest plot	7	1396	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.38, 0.92]

2 Recurrence of seizures Show forest plot	7	1390	Risk Ratio (M‐H, Fixed, 95% CI)	0.42 [0.33, 0.54]

3 Cerebrovascular accident (stroke) Show forest plot	4	1225	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.32, 1.18]

4 Any serious morbidity (stroke, renal failure, HELLP, DIC, pulmonary edema, cardiac arrest, or as reported Show forest plot	2	956	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.64, 1.19]

5 Renal failure Show forest plot	5	1164	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.53, 1.36]

6 Liver failure Show forest plot	2	974	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.48, 2.07]

7 Coagulopathy Show forest plot	4	1036	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.56, 1.41]

8 Side effects: local skin reaction Show forest plot	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

9 Pulmonary oedema Show forest plot	3	1013	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.35, 2.07]

10 Pneumonia Show forest plot	4	1125	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.31, 1.33]

11 Respiratory depression Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.57, 1.30]

12 Cardiac arrest Show forest plot	4	1085	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.41, 1.54]

13 Death or any serious maternal morbidity Show forest plot	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.80, 1.41]

14 Woman admitted to intensive care unit Show forest plot	3	1034	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.59, 1.07]

15 Maternal ventilation Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.45, 1.18]

16 Labour > 8 hours Show forest plot	1	633	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.82, 1.60]

17 Caesarean section Show forest plot	5	777	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.79, 1.43]

18 Blood loss at birth > 500 ml Show forest plot	3	715	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.74, 1.28]

19 Death of the fetus or infant Show forest plot	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

19.1 Stillbirth	5	799	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.70, 1.34]
19.2 Perinatal death	4	788	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.81, 1.34]
19.3 Neonatal death	4	759	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.75, 1.84]
20 Preterm birth Show forest plot	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

20.1 Preterm birth < 37 weeks	2	94	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.46, 1.38]
20.2 Preterm birth < 32‐34 weeks	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	2.25 [0.63, 8.03]
21 Apgar scores Show forest plot	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

21.1 Apgar < 7 at 1 minute	2	597	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.65, 0.87]
21.2 Apgar < 7 at 5 minutes	3	643	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.54, 0.90]
22 Admitted to special care baby unit (SCBU) Show forest plot	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

22.1 Stay in SCBU > 7 days	3	634	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.46, 0.96]
22.2 Admission to SCBU	3	634	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.79, 1.06]
23 Death or in SCBU > 7 days Show forest plot	2	688	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.77, 1.16]

24 Intubation at place of birth Show forest plot	2	591	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.45, 1.00]

Comparison 1. Magnesium sulphate versus diazepam

Ir a la tabla de la revisión

Comparison 2. Magnesium sulphate versus diazepam (subgroups by whether randomisation before or after birth)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death Show forest plot	7	1396	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.38, 0.92]

1.1 Randomised before delivery	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	3.36 [0.14, 78.79]
1.2 Randomised after delivery	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 Mixed, or unclear whether randomised before delivery	6	1345	Risk Ratio (M‐H, Fixed, 95% CI)	0.56 [0.36, 0.88]
2 Recurrence of seizures Show forest plot	7	1390	Risk Ratio (M‐H, Fixed, 95% CI)	0.42 [0.33, 0.54]

2.1 Randomised before delivery	2	684	Risk Ratio (M‐H, Fixed, 95% CI)	0.55 [0.40, 0.74]
2.2 Randomised after delivery	1	272	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.21, 0.64]
2.3 Mixed, or unclear whether randomised before delivery	5	434	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.11, 0.40]
3 Stroke Show forest plot	4	1225	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.32, 1.18]

3.1 Randomised before delivery	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.02, 8.75]
3.2 Randomised after delivery	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 Mixed, or unclear whether randomised before delivery	3	1174	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.33, 1.22]

Comparison 2. Magnesium sulphate versus diazepam (subgroups by whether randomisation before or after birth)

Ir a la tabla de la revisión

Comparison 3. Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death Show forest plot	7	1396	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.38, 0.91]

1.1 Anticonvulsant before trial entry	1	34	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 68.84]
1.2 No anticonvulsant before trial entry	1	17	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 Mixed, or unclear whether anticonvulsant before trial entry	6	1345	Risk Ratio (M‐H, Fixed, 95% CI)	0.56 [0.36, 0.88]
2 Recurrence of seizures Show forest plot	7	1369	Risk Ratio (M‐H, Fixed, 95% CI)	0.43 [0.34, 0.56]

2.1 Anticonvulsant before trial entry	2	447	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.41, 0.85]
2.2 No anticonvulsant before trial entry	2	488	Risk Ratio (M‐H, Fixed, 95% CI)	0.44 [0.30, 0.65]
2.3 Mixed, or unclear whether anticonvulsant before trial entry	5	434	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.11, 0.40]
3 Any serious maternal morbidity Show forest plot	2	956	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.65, 1.20]

3.1 Anticonvulsant before trial entry	1	34	Risk Ratio (M‐H, Fixed, 95% CI)	0.43 [0.13, 1.39]
3.2 No anticonvulsant before trial entry	1	17	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.38, 1.74]
3.3 Mixed, or unclear whether anticonvulsant before trial entry	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.67, 1.33]
4 Perinatal death Show forest plot	4	788	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.83, 1.35]

4.1 Anticonvulsant before trial entry	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	1.89 [0.19, 19.13]
4.2 No anticonvulsant before trial entry	1	20	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.08, 6.96]
4.3 Mixed, or unclear whether anticonvulsant before trial entry	3	731	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.82, 1.35]
5 Neonatal death Show forest plot	4	759	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.76, 1.84]

5.1 Anticonvulsant before trial entry	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	2.85 [0.12, 65.74]
5.2 No anticonvulsant before trial entry	1	20	Risk Ratio (M‐H, Fixed, 95% CI)	4.33 [0.20, 94.83]
5.3 Mixed, or unclear whether anticonvulsant before trial entry	3	702	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.71, 1.75]
6 Stay in SCBU > 7 days Show forest plot	2	600	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.44, 0.93]

6.1 Anticonvulsant before trial entry	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	0.47 [0.10, 2.28]
6.2 No anticonvulsant before trial entry	1	20	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.21, 4.71]
6.3 Mixed, or unclear whether anticonvulsant before trial entry	1	543	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.43, 0.94]

Comparison 3. Magnesium sulphate versus diazepam (subgroups by whether anticonvulsants before randomisation)

Ir a la tabla de la revisión

Comparison 4. Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal cardiac arrest Show forest plot	4	1085	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.41, 1.54]

1.1 IM magnesium sulphate maintenance	2	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.10, 2.66]
1.2 IV magnesium sulphate maintenance	1	60	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.65]
1.3 Mixed, or route for maintenance unclear	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.50, 2.34]
2 Maternal respiratory depression Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.57, 1.30]

2.1 IM magnesium sulphate maintenance	2	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.30 [0.10, 0.93]
2.2 IV magnesium sulphate maintenance	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 Mixed, or route of maintenance unclear	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.67, 1.67]
3 Pneumonia Show forest plot	4	1125	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.31, 1.33]

3.1 IM magnesium sulphate maintenance	3	220	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.15, 2.87]
3.2 IV magnesium sulphate maintenance	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 Mixed, or route of maintenance unclear maintenance	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.28, 1.47]
4 Maternal ventilation Show forest plot	3	1025	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.45, 1.18]

4.1 IM magnesium sulphate maintenance	2	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.05, 0.88]
4.2 IV magnesium sulphate maintenance	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.3 Mixed maintenance	1	905	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.54, 1.57]

Comparison 4. Magnesium sulphate versus diazepam (subgroups by route of magnesium maintenance)

Ir a la tabla de la revisión

The Cochrane Library

Scolaris Language Selector Scolaris Language Selector

Idioma de la Revisión Cochrane

Idioma de la web

Scolaris Content Language Banner Portlet Scolaris Content Language Banner Portlet