This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effectiveness and safety of exercise or physical activity interventions, or both, on the disease‐related physical and mental health of individuals diagnosed with non‐advanced colorectal cancer, staged as T1‐4 N0‐2 M0, treated surgically with or without neoadjuvant or adjuvant therapy (i.e. chemotherapy, radiotherapy or chemoradiotherapy).