This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the efficacy of linezolid when used as part of a second‐line regimen for treating people with multidrug‐resistant (MDR‐) and extensively drug‐resistant (XDR‐) pulmonary tuberculosis (TB), and to assess the prevalence and severity of adverse events associated with linezolid use in this patient group.