This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Primary objective

To evaluate the impact of space spraying on malaria transmission and vector populations, or the incremental impact when applied in combination with other malaria control methods, in comparison to equivalent conditions with no space spraying intervention.

Secondary objective

To guide future evaluations of strategies for which there is currently insufficient evidence to reliably assess the impact on malaria transmission, by identifying the following.

• The range of space spraying strategies that have been trialled.

• Potentially promising strategies that have been used and warrant further evaluation.

• Strategies that have been used and appear unlikely to warrant further evaluation (for example, because they were found to be infeasible or unacceptable).