This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the potential benefits and possible harms of patient‐specific cutting guides versus conventional instruments or computer‐assisted surgery for total knee arthroplasty. We will examine improvements in lower limb alignment and other clinical outcomes in participants undergoing TKA surgery.

We will conduct this review according to the guidelines recommended by the Cochrane Musculoskeletal Group Editorial Board (Ghogomu 2014).