This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effects of degarelix compared with standard systemic androgen suppression therapy (in the form of surgical castration, medical castration using GnRH agonists, non‐steroidal or steroidal antiandrogen monotherapy, or combination therapy of surgical or medical castration with antiandrogens) for men with advanced hormone‐sensitive prostate cancer.